<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2022-15-3-123-127</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-1060</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FOR OPHTHALMOLOGY PRACTITIONERS</subject></subj-group></article-categories><title-group><article-title>Применение локального УФА-кросслинкинга при язве роговицы у ребенка. Клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>Local corneal UVA crosslinking used for corneal ulcer treatment in a child. A clinical case</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0874-6504</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамакаева</surname><given-names>И. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamakaeva</surname><given-names>I. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Индира Рахимжановна Мамакаева — кандидат медицинских наук, научный сотрудник отдела патологии глаз у детей.</p><p>Ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Indira R. Mamakaeva — Cand. of Med. Sci., researcher, department of children’s eye pathology.</p><p>14/19, Sadovaya Chernogryazskaya St., Moscow, 105062</p></bio><email xlink:type="simple">imamakaeva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4458-4605</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плескова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pleskova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алла Вячеславовна Плескова — доктор медицинских наук, старший научный сотрудник отдела патологии глаз у детей.</p><p>Ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Alla V. Pleskova — Dr. of Med. Sci., senior researcher, department of children’s eye pathology.</p><p>14/19, Sadovaya Chernogryazskaya St., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8143-3606</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иомдина</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Iomdina</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Наумовна Иомдина — доктор биологических наук, профессор, главный научный сотрудник отдела патологии рефракции, бинокулярного зрения и офтальмоэргономики.</p><p>Ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Elena N. Iomdina — Dr. of Biol. Sci., professor, principal researcher, department of refraction pathology, binocular vision and ophthalmoergonomics.</p><p>14/19, Sadovaya Chernogryazskaya St., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4857-0374</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катаргина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Katargina</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Людмила Анатольевна Катаргина — доктор медицинских наук, профессор, начальник отдела патологии глаз у детей, заместитель директора по научной работе.</p><p>Ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Lyudmila A. Katargina — Dr. of Med. Sci., professor, head of the department of children’s eye pathology, deputy director.</p><p>14/19, Sadovaya Chernogryazskaya St., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Helmholtz National Medical Research Center of Eye Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>23</day><month>09</month><year>2022</year></pub-date><volume>15</volume><issue>3</issue><fpage>123</fpage><lpage>127</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мамакаева И.Р., Плескова А.В., Иомдина Е.Н., Катаргина Л.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Мамакаева И.Р., Плескова А.В., Иомдина Е.Н., Катаргина Л.А.</copyright-holder><copyright-holder xml:lang="en">Mamakaeva I.R., Pleskova A.V., Iomdina E.N., Katargina L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/1060">https://roj.igb.ru/jour/article/view/1060</self-uri><abstract><p>Цель работы — оценить результаты применения локального ультрафиолетового (УФА) кросслинкинга в комплексном лечении рецидивирующей язвы роговицы у ребенка. Пациент К., 6 лет, находился на лечении в отделе патологии глаз у детей ФГБУ «НМИЦ ГБ им. Гельмгольца» с диагнозом «язва роговицы». Из анамнеза: болен в течение 2 лет, периоды ремиссии чередовались с обострением, при иммунологическом обследовании выявлена сенсибилизация к вирусу простого герпеса I и II типа (IgG = 3,2 при норме &lt; 0,18). Комплексное лечение включало медикаментозную терапию и локальный УФА-кросслинкинг роговицы (7 процедур по 6 мин через день). По данным оптической когерентной томографии (ОКТ) на фоне лечения зафиксирована положительная динамика: уменьшение глубины и площади инфильтрата роговицы. Через месяц после последней процедуры отмечено купирование воспалительного процесса и постепенное восстановление прозрачности роговицы, снижение ее васкуляризации. Через 2 мес зона инфильтрата просветлела на всем протяжении. По ОКТ выявлено постепенное уменьшение толщины инфильтрата и его замещение прозрачной тканью роговицы.</p><p>Заключение. Полученный эффект свидетельствует о значительной перспективности применения локального УФА роговичного кросслинкинга в качестве компонента комплексного лечения кератитов и язв роговицы у детей.</p></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: to evaluate the results of corneal ultraviolet (UVA) crosslinking used in the complex treatment of recurrent corneal ulcer in a child. Patient K., 6, was treated in the department of children eye pathology with the diagnosis of corneal ulcer. The case history said the patient was sick for 2 years, periods of remission alternated with exacerbation. Immunological examination revealed sensitization to herpes simplex virus types 1 and 2 (IgG = 3.2 with the norm of &lt; 0.18). The combined treatment included drug therapy and local UVA crosslinking of the cornea (7 procedures per 6 minutes every other day). Optical coherence tomography showed positive changes during treatment: the depth and area of cornea infiltrate became smaller. 1 month after the last procedure, the inflammatory process was stopped and the corneal clarity gradually restored whilst vascular activity became less intense. After 2 months, the infiltrate area became clear throughout. OCT revealed a gradual decrease of the infiltrate thickness and a replacement of the cornea with a transparent tissue.</p></sec><sec><title>Conclusion</title><p>Conclusion. Local corneal UV-crosslinking used as part of the complex treatment of keratitis and corneal ulcers in children is a very promising method for implementation in clinical practice.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>роговичный УФА-кросслинкинг</kwd><kwd>кератит</kwd><kwd>язва роговицы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>UVA-corneal crosslinking</kwd><kwd>keratitis</kwd><kwd>corneal ulcer</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Colby C., ed. Сorneal diseases in children. Challenges and controversies. New York: Springer, 2017.</mixed-citation><mixed-citation xml:lang="en">Colby C., ed. Сorneal diseases in children. Challenges and controversies. New York: Springer, 2017.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Яни Е.В., Иомдина Е.Н., Позднякова В.В., Голикова В.А., Селиверстова К.Е. Лечение язв роговицы затяжного течения с помощью ультрафиолетового кросслинкинга роговичного коллагена. Клинические случаи. Российский офтальмологический журнал. 2021; 14 (3): 106–12. https://doi.org/10.21516/2072-0076-2021-14-3-106-112</mixed-citation><mixed-citation xml:lang="en">Yani E.V., Iomdina E.N., Pozdnyakova V.V., Golikova V.A., Seliverstova K.E. Treatment of protracted corneal ulcers using ultraviolet corneal collagen crosslinking. Clinical cases. Russian ophthalmological journal. 2021; 14 (3): 106–12 (in Russian)]. https://doi.org/10.21516/2072-0076-2021-14-3-106-112</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Хрипун К.В., Кобинец Ю.В., Данилов П.А. и др. Кросслинкинг роговичного коллагена в лечении кератитов смешанной этиологии: случай успешного применения. Офтальмологические ведомости. 2020; 13 (3): 87–96. doi: 10.17816/OV26057</mixed-citation><mixed-citation xml:lang="en">Khripun K.V., Kobinets Y.V., Danilov P.A., et al. Corneal collagen cross-linking in mixed etiology keratitis treatment: a case of successful use. Ophthalmology journal. 2020; 13 (3): 87–96 (in Russian). doi: 10.17816/OV26057</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Каспарова Е.А., Федоров А.А., Ян Б. Клинические результаты модифицированного кросслинкинга в лечении гнойных кератитов и язв роговицы. Вестник офтальмологии. 2020; 136 (3): 64–73. https://doi.org/10.17116/oftalma202013603164</mixed-citation><mixed-citation xml:lang="en">Kasparova E.A., Fedorov A.A., Yan B. Clinical results of modified crosslinking in the treatment of purulent keratitis and corneal ulcers. Vestnik oftal’mologii. 2020; 136 (3): 64–73 (in Russian). https://doi.org/10.17116/oftalma202013603164</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ченцова Е.В., Вериго Е.Н., Макаров П.В., Хазамова А.И. Кросслинкинг в комплексном лечении язв роговицы и трансплантата. Российский офтальмологический журнал. 2017; 10 (3): 93–100. https://doi.org/10.21516/2072-0076-2017-10-3-93-100</mixed-citation><mixed-citation xml:lang="en">Chentsova E.V., Verigo E.N., Makarov P.V., Khazamova A.I. Crosslinking in the complex treatment of corneal ulceration and corneal grafting. Russian ophthalmological journal. 2017; 10 (3): 93–100 (in Russian)]. https://doi.org/10.21516/2072-0076-2017-10-3-93-100</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Нероев В.В., Яни Е.В., Иомдина Е.Н. и др. Лечение язв роговицы с помощью локального ультрафиолетового кросслинкинга (экспериментальное исследование). Российский офтальмологический журнал. 2020; 13 (4): 48–57. https://doi.org/10.21516/2072-0076-2020-13-4-48-57</mixed-citation><mixed-citation xml:lang="en">Neroev V.V., Yani E.V., Iomdina E.N., et al. Treatment of corneal ulcers using local ultraviolet crosslinking (experimental study). Russian ophthalmological journal. 2020; 13 (4): 48–57 (in Russian)]. https://doi.org/10.21516/2072-0076-2020-13-4-48-57</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Makdoumi K., Mortensen J.C. Infectious keratitis treated with corneal crosslinking. Cornea. 2010; 29 (12): 1353–8. https://doi.org/10.1097/ICO.0b013e3181d2de91</mixed-citation><mixed-citation xml:lang="en">Makdoumi K., Mortensen J.C. Infectious keratitis treated with corneal crosslinking. Cornea. 2010; 29 (12): 1353–8. https://doi.org/10.1097/ICO.0b013e3181d2de91</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hafezi F., Randleman J.B. PACK-CXL: defining CXL for infectious keratitis. J. Refract. Surg. 2014; 30: 438–9. https://doi.org/10.3928/1081597X-20140609-01</mixed-citation><mixed-citation xml:lang="en">Hafezi F., Randleman J.B. PACK-CXL: defining CXL for infectious keratitis. J. Refract. Surg. 2014; 30: 438–9. https://doi.org/10.3928/1081597X-20140609-01</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Knyazer B., Krakauer Y., Baumfeld Y., et al. Accelerated PACK-CXL for moderate therapy-resistant infectious keratitis. Cornea. 2018; 37: 528–31. https://doi.org/10.1097/ICO.0000000000001498</mixed-citation><mixed-citation xml:lang="en">Knyazer B., Krakauer Y., Baumfeld Y., et al. Accelerated PACK-CXL for moderate therapy-resistant infectious keratitis. Cornea. 2018; 37: 528–31. https://doi.org/10.1097/ICO.0000000000001498</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Murchison C.E., Petroll W.M., Robertson D.M. Infectious keratitis after corneal crosslinking: systematic review. J. Cataract Refract. Surg. 2021 Aug 1; 47 (8): 1075–80. doi: 10.1097/j.jcrs.0000000000000620</mixed-citation><mixed-citation xml:lang="en">Murchison C.E., Petroll W.M., Robertson D.M. Infectious keratitis after corneal crosslinking: systematic review. J. Cataract Refract. Surg. 2021 Aug 1; 47 (8): 1075–80. doi: 10.1097/j.jcrs.0000000000000620</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Zloto O., Barequet I.S., Weissman A., et al. Does PACK-CXL change the prognosis of resistant infectious keratitis? J. Refract. Surg. 2018 Aug 1; 34 (8): 559–563. doi: 10.3928/1081597X-20180705-01</mixed-citation><mixed-citation xml:lang="en">Zloto O., Barequet I.S., Weissman A., et al. Does PACK-CXL change the prognosis of resistant infectious keratitis? J. Refract. Surg. 2018 Aug 1; 34 (8): 559–563. doi: 10.3928/1081597X-20180705-01</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Wollensak G., Sporl E., Seiler T. Treatment of keratoconus by collagen cross linking. J. Ophthalmology. 2003; 100 (1): 44–9. https://doi.org/10.1007/s00347-002-0700-3</mixed-citation><mixed-citation xml:lang="en">Wollensak G., Sporl E., Seiler T. Treatment of keratoconus by collagen cross linking. J. Ophthalmology. 2003; 100 (1): 44–9. https://doi.org/10.1007/s00347-002-0700-3</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">McAnena L., O’Keefe M. Corneal collagen crosslinking in children with keratoconus. JAPOS. 2015; 19: 228–32.</mixed-citation><mixed-citation xml:lang="en">McAnena L., O’Keefe M. Corneal collagen crosslinking in children with keratoconus. JAPOS. 2015; 19: 228–32.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Greenstein S. A., Hersh P. S. Corneal crosslinking for progressive keratoconus and corneal ectasia: summary of US Multicenter and Subgroup Clinical Trials. Translational Vision Science &amp; Technology. 2021; 10 (5): 13. doi: 10.1167/tvst.10.5.13</mixed-citation><mixed-citation xml:lang="en">Greenstein S. A., Hersh P. S. Corneal crosslinking for progressive keratoconus and corneal ectasia: summary of US Multicenter and Subgroup Clinical Trials. Translational Vision Science &amp; Technology. 2021; 10 (5): 13. doi: 10.1167/tvst.10.5.13</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Mastropasqua L. Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives. Eye and Vision. 2015; 2: 19. doi:10.1186/s40662-015-0030-6</mixed-citation><mixed-citation xml:lang="en">Mastropasqua L. Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives. Eye and Vision. 2015; 2: 19. doi:10.1186/s40662-015-0030-6</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Said D.G., Elalfy M.S., Gatzioufas Z., et al. Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting. Ophthalmology. 2014; 121 (7): 1377–82. http://dx.doi.org/10.1016/j.ophtha.2014.01.011</mixed-citation><mixed-citation xml:lang="en">Said D.G., Elalfy M.S., Gatzioufas Z., et al. Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting. Ophthalmology. 2014; 121 (7): 1377–82. http://dx.doi.org/10.1016/j.ophtha.2014.01.011</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Иомдина Е.Н., Ханджян А.Т., Яни Е.В. и др. Устройство для кросслинкинга роговицы. Патент РФ № 199825 от 22.09. 2020, бюл. No 27.</mixed-citation><mixed-citation xml:lang="en">Iomdina E.N., Khandzhian A.T., Yani E.V., et al. Device for corneal crosslinking. Patent RU # 199825, 22.09. 2020; bull. 27 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Price M.O., Tenkman L.R., Schrier A., et al. Photoactivated riboflavin treatment of infectious keratitis using collagen cross-linking technology. J. Refract. Surg. 2012; 28 (10): 706–13. doi: 10.3928/1081597X-2012092106.17</mixed-citation><mixed-citation xml:lang="en">Price M.O., Tenkman L.R., Schrier A., et al. Photoactivated riboflavin treatment of infectious keratitis using collagen cross-linking technology. J. Refract. Surg. 2012; 28 (10): 706–13. doi: 10.3928/1081597X-2012092106.17</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Papaioannou L., Miligkos M., Papathanassiou M. Corneal collagen cross-linking for infectious keratitis: a systematic review and Metaanalysis. Cornea. 2016; 35 (1): 62–71.</mixed-citation><mixed-citation xml:lang="en">Papaioannou L., Miligkos M., Papathanassiou M. Corneal collagen cross-linking for infectious keratitis: a systematic review and Metaanalysis. Cornea. 2016; 35 (1): 62–71.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Wróblewska-Czajka E, Nowińska A, Dobrowolski D., Szkodny D., Wylęgała E. A retrospective study of herpetic keratitis in patients with keratoconus after crosslinking surgery. J. Clin. Med. 2021; 10 (12): 2684. doi:10.3390/jcm10122684</mixed-citation><mixed-citation xml:lang="en">Wróblewska-Czajka E, Nowińska A, Dobrowolski D., Szkodny D., Wylęgała E. A retrospective study of herpetic keratitis in patients with keratoconus after crosslinking surgery. J. Clin. Med. 2021; 10 (12): 2684. doi:10.3390/jcm10122684</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
