helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2022-15-3-157-162helmholtzeyeinstitute-1066Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSТоксическое поражение зрительного нерва при курении табачной смеси с использованием кальянаToxic damage of the optic nerve by smoking a tobacco mixture using a hookahИойлеваЕ. Э.IoylevaE. E.

Елена Эдуардовна Иойлева — доктор медицинских наук, ученый секретарь, профессор кафедры глазных болезней ФГАУ НМИЦ «МНТК "Микрохирургия глаза" им. акад. С.Н. Федорова, профессор кафедры глазных болезней МГМСУ им. А.И. Евдокимова.

Бескудниковский бульвар, д. 59 а, Москва, 127486; ул. Делегатская, д. 20, строение 1, Москва, 127473

Elena E. Ioyleva — Dr. of Med. Sci., professor, scientific secretary, professor of chair of eye diseases S. Fyodorov EMC, professor of chair of eye diseases A.I. Yevdokimov MSUMD.

59a, Beskudnikovsky Blvd, Moscow, 127486; 20, Bldg. 1, Delegatskaya St., Moscow, 127473

БратчукА. А.BratchukA. А.

Анна Алексеевна Братчук — врач-ординатор кафедры глазных болезней.

Ул. Делегатская, д. 20, строение 1, Москва, 127473

Anna A. Bratchuk — resident, chair of eye diseases.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

anutkasurkova2010@yandex.ruХабазоваМ. Р.KhabazovaM. R.

Маргарита Робертовна Хабазова — врач-ординатор кафедры глазных болезней.

Ул. Делегатская, д. 20, строение 1, Москва, 127473

Margarita R. Khabazova — resident, chair of eye diseases.

20, Bldg. 1, Delegatskaya St., Moscow, 127473

ФГАУ НМИЦ «МНТК "Микрохирургия глаза" им. акад. С.Н. Федорова» Минздрава России; ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» МинздраваРоссияS. Fyodorov Eye Microsurgery Clinic; A.I. Yevdokimov Moscow State University of Medicine and DentistryRussian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» МинздраваРоссияA.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation202224092022153157162Copyright © Иойлева Е.Э., Братчук А.А., Хабазова М.Р., 20222022Иойлева Е.Э., Братчук А.А., Хабазова М.Р.Ioyleva E.E., Bratchuk A.А., Khabazova M.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/1066

В последние годы отмечается рост приверженцев курения табачных смесей с использованием кальянов. Опасные вещества, выделяющиеся при курении, наносят огромный вред всему организму, а также вызывают нарушение зрительных функций с развитием токсической оптической нейропатии. Наиболее восприимчивыми к повреждению токсинами структурами глаза являются клетки зрительного нерва (ЗН) и сетчатки. Вещества, выделяющиеся при курении табачных смесей для кальянов, оказывают прямой нейротоксический эффект на ЗН, а также вызывают метаболическое повреждение слоя нервных волокон сетчатки и ганглиозных клеток. Трудность своевременного выявления этого поражения вызвана схожестью его клинической картины с другими заболеваниями ЗН, что требует тщательной дифференциальной диагностики.

Recent years have seen an increase in tobacco mixture smokers using hookahs. Dangerous substances released during smoking cause substantial harm to the entire body, and bring about visual impairment with toxic optical neuropathy. Eye structures which are the most susceptible to toxin damage are the cells of the optic nerve and retina. Substances released when smoking hookah tobacco mixtures have a direct neurotoxic impact on the optic nerve and cause metabolic damage to the retinal nerve fiber layer and ganglion cells. Timely detection of this damage is complicated by the similarity of its clinical picture with other optic nerve diseases, which requires a thorough differential diagnosis.

атрофия зрительного нерватоксическая оптическая нейропатияоптическая когерентная томографиязрительный анализатортабачная продукциякальяныoptic nerve atrophytoxic optical neuropathyoptical coherence tomographyvisual analyzertobacco productshookahsReferencesWHO report on the global tobacco epidemic, 2017. Monitoring tobacco use and prevention policies. WHO, Geneva. 2018.WHO report on the global tobacco epidemic, 2017. Monitoring tobacco use and prevention policies. WHO, Geneva. 2018.Grzybowski A., Z lsdorff M., Wilhelm H., Tonagel F. Toxic optic neuropathies: an updated review. Acta Ophthalmol. 2015 Aug; 93 (5): 402–10. doi: 10.1111/aos.12515Grzybowski A., Z lsdorff M., Wilhelm H., Tonagel F. Toxic optic neuropathies: an updated review. Acta Ophthalmol. 2015 Aug; 93 (5): 402–10. doi: 10.1111/aos.12515Patel M.P., Khangoora V.S., Marik P.E. A review of the pulmonary and health impact of hookah use. Ann. Am. Thorac Soc. 2019; 16 (10): 1215–9. doi: 10.1513/AnnalsATS.201902-129CMEPatel M.P., Khangoora V.S., Marik P.E. A review of the pulmonary and health impact of hookah use. Ann. Am. Thorac Soc. 2019; 16 (10): 1215–9. doi: 10.1513/AnnalsATS.201902-129CMEKolar P. Risk factors for central and branch retinal vein occlusion: a meta-analysis of published clinical data. J. Ophthalmol. 2014; doi: 10.1155/2014/724780.724780Kolar P. Risk factors for central and branch retinal vein occlusion: a meta-analysis of published clinical data. J. Ophthalmol. 2014; doi: 10.1155/2014/724780.724780Иойлева Е.Э., Зиновьева А.В. Атрофия зрительного нерва при героиновой интоксикации. Офтальмология. 2020; 17 (1): 152–7. doi: 10.1007/s40278-020-81611-5Ioyleva E.E., Zinov'eva A.V. Atrophy of the optic nerve in heroin intoxication. Ophthalmology in Russia. 2020; 17 (1): 152–7 (in Russian)]. doi: 10.1007/s40278-020-81611-5Иойлева Е.Э., Куракина Е.С., Андрусякова Е.П., Саиф М.А.С. Токсическое поражение зрительной системы при непреднамеренном отравлении салициланилидом. Российская детская офтальмология. 2020; 3: 54–60. doi 10.25276/23076658-2020-3-54-60Ioyleva E.E., Kurakina E.S., Andrusyakova E.P., Saif M.A.S. Toxic damage to the visual system in unintentional poisoning with salicylanilide. Rossiyskaya detskaya oftal'mologiya. 2020; 3: 54–60 (in Russian)]. doi 10.25276/23076658-2020-3-54-60Шеремет Н.Л., Андреева Н.А., Мешков А.Д. и др. Этиологическая структура неглаукомных оптических нейропатий. Сибирский научный медицинский журнал. 2018; 38 (5): 25–31. doi: 10.15372/SSMJ20180504Sheremet N.L., Andreeva N.A., Meshkov A.D., et al. Etiological structure of non-glaucoma optic neuropathies. Sibirskiy nauchnyy meditsinskiy zhurnal. 2018; 38 (5): 25–31 (in Russian)]. doi: 10.15372/SSMJ20180504El-Shazly A.A., Farweez Y.A.T., Elewa L.S., Elzankalony Y.A., Farweez B.A.T. Effect of active and passive smoking on retinal nerve fibre layer and ganglion cell complex. J. Ophthalmol. 2017; 10. doi: 10.1155/2017/6354025. Article ID 6354025.El-Shazly A.A., Farweez Y.A.T., Elewa L.S., Elzankalony Y.A., Farweez B.A.T. Effect of active and passive smoking on retinal nerve fibre layer and ganglion cell complex. J. Ophthalmol. 2017; 10. doi: 10.1155/2017/6354025. Article ID 6354025.Abdelshafy M., Abdelshafy A. Functional and structural changes of the retinal nerve fiber layer and ganglion cell complex in heavy smokers. Clin. Ophthalmol. 2020 Feb 12; 14: 397–404. doi: 10.2147/OPTH.S235892Abdelshafy M., Abdelshafy A. Functional and structural changes of the retinal nerve fiber layer and ganglion cell complex in heavy smokers. Clin. Ophthalmol. 2020 Feb 12; 14: 397–404. doi: 10.2147/OPTH.S235892Kerrison J.B. Optic neuropathies caused by toxins and adverse drug reactions. Ophthalmol. Clin. North Am. 2004; 17 (3): 481–8. doi: https://doi.org/10.1016/j.ohc.2004.05.005Kerrison J.B. Optic neuropathies caused by toxins and adverse drug reactions. Ophthalmol. Clin. North Am. 2004; 17 (3): 481–8. doi: https://doi.org/10.1016/j.ohc.2004.05.005Остроумова О.Д., Ших Е.В., Реброва Е.В. и др. Лекарственно-индуцированная токсическая оптическая невропатия. Вестник офтальмологии. 2020; 136 (4): 156–64. https://doi.org/10.17116/oftalma2020136041156Ostroumova O.D., Shikh E.V., Rebrova E.V., et al. Drug-induced toxic optical neuropathy. Vestnik oftal'mologii. 2020; 136 (4): 156–64 (in Russian)]. https://doi.org/10.17116/oftalma2020136041156Phillips P.H. Toxic and deficiency optic neuropathies. In: Miller N.R., Newman N.J., Biousse V., Kerrison J.B., eds. Walsh and Hoyt’s Clinical Neuro-ophthalmology. 2005; 6: 455–6.Phillips P.H. Toxic and deficiency optic neuropathies. In: Miller N.R., Newman N.J., Biousse V., Kerrison J.B., eds. Walsh and Hoyt’s Clinical Neuro-ophthalmology. 2005; 6: 455–6.Behbehani R. Clinical approach to optic neuropathies. Clin. Ophthalmol. 2007; 1 (3 Sep.): 233–46. PMID: 19668477Behbehani R. Clinical approach to optic neuropathies. Clin. Ophthalmol. 2007; 1 (3 Sep.): 233–46. PMID: 19668477Dervi o ullar M.S., Totan Y., Tenlik A., Y ce A., G ler E. Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex. Cutan. Ocul. Toxicol. 2015; 34 (4): 282–5. doi:10.3109/15569527.2014.975240Dervi o ullar M.S., Totan Y., Tenlik A., Y ce A., G ler E. Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex. Cutan. Ocul. Toxicol. 2015; 34 (4): 282–5. doi:10.3109/15569527.2014.975240Moschos M.M., Nitoda E., Laios K., Ladas D.S., Chatziralli I.P. The impact of chronic tobacco smoking on retinal and choroidal thickness in Greek population. Oxid. Med. Cell Longev. 2016; 2016:290578. doi: 10.1155/2016/2905789Moschos M.M., Nitoda E., Laios K., Ladas D.S., Chatziralli I.P. The impact of chronic tobacco smoking on retinal and choroidal thickness in Greek population. Oxid. Med. Cell Longev. 2016; 2016:290578. doi: 10.1155/2016/2905789Spinazzi M. Optic neuropathies caused by micronutrient deficiencies and toxins. Handbook of Nutrition, Diet and the Eye. 2014: 383–92. doi: 10.1016/B9780-12-401717-7.00039-3Spinazzi M. Optic neuropathies caused by micronutrient deficiencies and toxins. Handbook of Nutrition, Diet and the Eye. 2014: 383–92. doi: 10.1016/B9780-12-401717-7.00039-3Шеремет Н.Л., Андреева Н.А., Жоржоладзе Н.В. и др. Особенности структурных и функциональных изменений сетчатки и зрительного нерва у пациентов с токсической оптической нейропатией на фоне отравления метанолом. Вестник офтальмологии. 2020; 136 (4–2): 243–50. doi: 10.17116/oftalma2020136042243Sheremet N.L., Andreeva N.A., Zhorzholadze N.V., et al. Features of structural and functional changes of the retina and optic nerve in patients with toxic optical neuropathy on the background of methanol poisoning. Vestnik oftal'mologii. 2020; 136 (4–2): 243–50 (in Russian)]. doi: 10.17116/oftalma2020136042243Cliff J., Nzwalo H., Muquingue H. Cyanide in the production of long-term adverse health effects in humans. Toxicology of Cyanides and Cyanogens. 2016: 98–112. doi: 10.1002/9781118628966Cliff J., Nzwalo H., Muquingue H. Cyanide in the production of long-term adverse health effects in humans. Toxicology of Cyanides and Cyanogens. 2016: 98–112. doi: 10.1002/9781118628966Elsayed Y., Dalibalta S., Abu-Farha N. Chemical analysis and potential health risks of hookah charcoal. Sci. Total Environ. 2016; 569–70: 262–8. doi:10.1016/j.scitotenv.2016.06.108Elsayed Y., Dalibalta S., Abu-Farha N. Chemical analysis and potential health risks of hookah charcoal. Sci. Total Environ. 2016; 569–70: 262–8. doi:10.1016/j.scitotenv.2016.06.108Shihadeh A., Salman R., Jaroudi E., et al. Does switching to a tobacco-free waterpipe product reduce toxicant intake? A crossover study comparing CO, NO, PAH, volatile aldehydes, tar and nicotine yields. Food Chem. Toxicol. 2012; 50 (5): 1494–8. doi:10.1016/j.fct.2012.02.041Shihadeh A., Salman R., Jaroudi E., et al. Does switching to a tobacco-free waterpipe product reduce toxicant intake? A crossover study comparing CO, NO, PAH, volatile aldehydes, tar and nicotine yields. Food Chem. Toxicol. 2012; 50 (5): 1494–8. doi:10.1016/j.fct.2012.02.041Harley D., Goodman J. Tobacco in history: The cultures of dependence, London and New York, Routledge, Medical History. 1993; 38 (2): 217–8. doi:10.1017/S0025727300059238Harley D., Goodman J. Tobacco in history: The cultures of dependence, London and New York, Routledge, Medical History. 1993; 38 (2): 217–8. doi:10.1017/S0025727300059238Akl E.A., Gunukula S.K., Aleem S., et al. The prevalence of waterpipe tobacco smoking among the general and specific populations: a systematic review. BMC Public Health. 2011 Apr 19;11: 244. doi: 10.1186/1471-2458-11-244Akl E.A., Gunukula S.K., Aleem S., et al. The prevalence of waterpipe tobacco smoking among the general and specific populations: a systematic review. BMC Public Health. 2011 Apr 19;11: 244. doi: 10.1186/1471-2458-11-244Warren C.W., Lea V., Lee J., et al. Change in tobacco use among 13–15 year old between 1999 and 2008: findings from the Global Youth Tobacco Survey. Global Health Promot. 2009;16 (Sup-pl): 38–90.Warren C.W., Lea V., Lee J., et al. Change in tobacco use among 13–15 year old between 1999 and 2008: findings from the Global Youth Tobacco Survey. Global Health Promot. 2009;16 (Sup-pl): 38–90.Jackson D., Aveyard P. Waterpipe smoking in students: prevalence, risk factors, symptoms of addiction, and smoke intake. Evidence from one British university. BMC Public Health 2008; 8: 174Jackson D., Aveyard P. Waterpipe smoking in students: prevalence, risk factors, symptoms of addiction, and smoke intake. Evidence from one British university. BMC Public Health 2008; 8: 174Warren C., Jones N., Eriksen M., Asma S. Patterns of global tobacco use in young people and implications for future chronic disease burden in adults. Lancet 2006; 367: 749–53.Warren C., Jones N., Eriksen M., Asma S. Patterns of global tobacco use in young people and implications for future chronic disease burden in adults. Lancet 2006; 367: 749–53.Moh’d Al-Mulla A., Abdou Helmy S., Al-Lawati J., Al Nasser S., Ali Abdel Rahman S., Almutawa A., et al. Prevalence of tobacco use among students aged 13–15 years in Health Ministers’ Council/Gulf Cooperation Council Member States, 2001–2004. J School Health 2008; 78: 337–43.Moh’d Al-Mulla A., Abdou Helmy S., Al-Lawati J., Al Nasser S., Ali Abdel Rahman S., Almutawa A., et al. Prevalence of tobacco use among students aged 13–15 years in Health Ministers’ Council/Gulf Cooperation Council Member States, 2001–2004. J School Health 2008; 78: 337–43.Maziak W., Taleb Z.B., Bahelah R., Islam F., Jaber R., Auf R., Salloum R.G. The global epidemiology of waterpipe smoking. Tob Control. 2015. doi: 10.1136/tobaccocontrol-2014-051903Maziak W., Taleb Z.B., Bahelah R., Islam F., Jaber R., Auf R., Salloum R.G. The global epidemiology of waterpipe smoking. Tob Control. 2015. doi: 10.1136/tobaccocontrol-2014-051903American Lung Association. Hookah Smoking: A Growing Threat to Public Health Issue Brief.pdf iconexternal icon Smokefree Communities Project, 2011.American Lung Association. Hookah Smoking: A Growing Threat to Public Health Issue Brief.pdf iconexternal icon Smokefree Communities Project, 2011.World Health Statistics, 2017: Monitoring health indicators in relation to the Sustainable Development Goals. Geneva: World Health Organization. 2018: 26–100.World Health Statistics, 2017: Monitoring health indicators in relation to the Sustainable Development Goals. Geneva: World Health Organization. 2018: 26–100.Grzybowski A., Holder G.E. Tobacco optic neuropathy (TON) – the historical and present concept of the disease. Acta Ophthalmol (Copenh). 2011; 89 (5): 495–9. doi:10.1111/j.1755-3768.2009.01853.xGrzybowski A., Holder G.E. Tobacco optic neuropathy (TON) – the historical and present concept of the disease. Acta Ophthalmol (Copenh). 2011; 89 (5): 495–9. doi:10.1111/j.1755-3768.2009.01853.xTamaki Y., Araie M., Nagahara M., Tomita K., Matsubara M. The acute effects of cigarettes smoking on human optic nerve head and posterior fundus circulation in light smokers. Eye. 2000; 14 (Part 1): 67–72. doi:10.1038/eye.2000.15Tamaki Y., Araie M., Nagahara M., Tomita K., Matsubara M. The acute effects of cigarettes smoking on human optic nerve head and posterior fundus circulation in light smokers. Eye. 2000; 14 (Part 1): 67–72. doi:10.1038/eye.2000.15Bertram K.M., Baglole C.J., Phipps R.P., Libby R.T. Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration. Am J Physiol Cell Physiol. 2009; 297: 1200–10. doi:10.1152/ajpcell.00126.2009Bertram K.M., Baglole C.J., Phipps R.P., Libby R.T. Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration. Am J Physiol Cell Physiol. 2009; 297: 1200–10. doi:10.1152/ajpcell.00126.2009Hepsen I.F., Evereklioglu C. Defective visual field tests in chronic heavy smokers. Acta Ophthalmol Scand. 2001; 79 (1): 53–6. doi:10.1034/j.16000420.2001.079001053.xHepsen I.F., Evereklioglu C. Defective visual field tests in chronic heavy smokers. Acta Ophthalmol Scand. 2001; 79 (1): 53–6. doi:10.1034/j.16000420.2001.079001053.xИойлева Е.Э. Способ лечения токсической оптической нейропатии, вызванной длительным приемом кодеинсодержащих лекарственных средств. Патент № 2424796, 12.05.2010.Ioyleva E.E. A method for the treatment of toxic optical neuropathy caused by prolonged use of codeinecontaining drugs. Patent RF № 2424796, 12.05.2010 (in Russian).Иойлева Е.Э. Способ лечения хронической токсической алкогольно-табачной оптической нейропатии. Патент № 2440074, 15.07.2010.Ioyleva E.E. Method of treatment of chronic toxic alcohol-tobacco optical neuropathy. Patent RF № 2440074, 15.07.2010 (in Russian).

The authors declare that there are no conflicts of interest present.