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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2017-10-3-49-54</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-108</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Изменения толщины корнеального эпителия в ранние сроки после ортокератологической коррекции по данным спектральной оптической когерентной томографии Avanti Rtvue XR</article-title><trans-title-group xml:lang="en"><trans-title>Changes of corneal epithelial thickness before and after OK-correction according to SD-OCT</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Милаш</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Milash</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарутта</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarutta</surname><given-names>E. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Московский НИИ глазных болезней им. Гельмгольца» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Helmholtz Research Institute of Eye Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2018</year></pub-date><volume>10</volume><issue>3</issue><fpage>49</fpage><lpage>54</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Милаш С.В., Тарутта Е.П., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Милаш С.В., Тарутта Е.П.</copyright-holder><copyright-holder xml:lang="en">Milash S.V., Tarutta E.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/108">https://roj.igb.ru/jour/article/view/108</self-uri><abstract><p>Цель : оценка толщины корнеального эпителия в ранние сроки после ортокератологической (ОК) коррекции по данным спектральной оптической когерентной томографии (OКT). Материал и методы . Обследовано 18 пациентов (36 глаз) в возрасте 12,11±1,68 лет с миопией -3,21±0,94 дптр и длиной переднезадней оси 24,47±0,7 мм. Всем пациентам проводили исследование толщины эпителия (ТЭ) с помощью спектрального OКT Avanti Rtvue XR (Optovue Inc., Fremont, CA, USA) с формированием карты диаметром 6 мм до и через 36,44±5,81 дней после коррекции ОК-линзами ESA - DL (Dr Lens Technology, Россия). Карта ТЭ делилась на 17 секторов с указанием среднего значения и три зоны (центральная 2 мм, парацентральная от 2 до 5 мм и средне периферическая от 5 до 6 мм). Вычисляли максимальное (Max) и минимальное (Min) значение ТЭ, разницу между ними (Max-Min) в зоне диаметром 5 мм и стандартное отклонение значения ТЭ в зоне измерения диаметром 5 мм (Std Dev). Результаты. ТЭ до подбора ОК-линз не отличалась между секторами карты диаметром 6 мм (p&gt;0,05). В центральной зоне ТЭ составила 53,1±1,68 мкм. Через 36,44±5,81 дней после воздействия ОК-линз в центральной зоне ТЭ снизилась на 16,6% от исходной, в парацентральной достоверно отличался только один сектор (S), в средне периферической зоне ТЭ увеличилась на 14,1% от исходной толщины. Max и Min ТЭ, Max-Min и Std Dev в зоне диаметром 5 мм значительно отличались после воздействия ОК-линз (p&lt;0,05). Заключение . После ОК-коррекции ТЭ достоверно снижается в центральной зоне (на 16,6%) и увеличивается в средне периферической (на 14,1%). Эти изменения обеспечивают уплощение передней поверхности роговицы и вносят решающий вклад в рефракционный эффект ОК-линз. Для цитирования: Милаш С.В., Тарутта Е.П. Изменения толщины корнеального эпителия в ранние сроки после ортокератологической коррекции по данным спектральной оптической когерентной томографии. Российский офтальмологический журнал. 2017; 10 (3): 49-54. doi: 10.21516/2072-0076-2017-10-3-49-54.</p></abstract><trans-abstract xml:lang="en"><p>Purpose: to evaluate the thickness of corneal epithelium after orthokeratological (OK) correction with the help of SDOCT. Material and methods: 18 patients (36 eyes) averagely aged 12.11 ± 1.68 with myopia of -3.21 ± 0.94 D and axial length of 24.47 ± 0.7 mm were examined. All patients were checked for corneal epithelial thickness (ET) with the help of SD-OCT Avanti RTVueXR (Optovue Inc., Fremont, CA, USA), which created maps of 6 mm in diameter before OK correction with lenses ESA-DL (Dr. Lens Technology, Russia) and 36.44 ± 5.81 days after it. A corneal ET map was divided into 17 sectors with average values indicated, and 3 zones (the central zone of 2 mm, the paracentral zone from 2 to 5 mm, and the mid-peripheral zone from 5 to 6 mm). We calculated the maximum (Max) and the minimum (Min) values of ET, the difference between them (Max Min) in the 5 mm zone, and standard deviation of values in the 5 mm zone (Std Dev). Results. The corneal ET showed no difference among the sectors of the 6-mm map (p &gt; 0.05) before OK lenses were worn. The ET in the central zone was 53.1 ± 1.68 μm. The ET in the central zone decreased by 16.6 % from the initial value after 36.44 ± 5.81 days of OK correction, with a single sector (S) showing a statistically significant difference in the paracentral zone. In the mid-peripheral zone, the ET increased by 14.1 % from the reference. Max and Min ET, and Max-Min Std Dev in the 5-mm zone differed significantly after OK correction (p &lt; 0.05). Conclusion. After OK correction, the ET significantly decreases in the central zone and increases in the mid-peripheral zone. These changes account for the flattening of the anterior corneal surface and contribute to the refractive effect of OK lenses. For citations: Milash S.V., Tarutta E.P. Changes of corneal epithelial thickness before and after OK-correction according to SD-OCT. Russian ophthalmological journal. 2017; 10 (3): 49-54. doi: 10.21516/2072-0076-2017-10-3-49-54 (in Russian).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>миопия</kwd><kwd>ортокератология</kwd><kwd>эпителий роговицы</kwd><kwd>myopia</kwd><kwd>orthokeratology</kwd><kwd>corneal epithelium</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Thomasy S.M., Krishna Raghunathan V., Winkler M., et al. Elastic modulus and collagen organization of the rabbit cornea: epithelium to endothelium. 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