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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2017-10-3-71-77</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-111</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>ЭФФЕКТИВНОСТЬ ТРАНСПУПИЛЛЯРНОЙ ТЕРМОТЕРАПИИ В КОМБИНИРОВАННОМ ЛЕЧЕНИИ МАЛЫХ КАЛЬЦИФИЦИРОВАННЫХ РЕТИНОБЛАСТОМ</article-title><trans-title-group xml:lang="en"><trans-title>Transpupillary thermotherapy efficiency in the combined treatment of small calcified retinoblastoma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саакян</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Saakyan</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тацков</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tatskov</surname><given-names>R. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мякошина</surname><given-names>Е. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Myakoshina</surname><given-names>E. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ушакова</surname><given-names>Т. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Ushakova</surname><given-names>T. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поляков</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Polyakov</surname><given-names>V. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Московский научно-исследовательский институт глазных болезней им. Гельмгольца» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Helmholtz Research Institute of Eye Diseases, Moscow, Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Московский научно-исследовательский институт глазных болезней им. Гельмгольца» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Children Oncology and Hematology, Moscow, Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2018</year></pub-date><volume>10</volume><issue>3</issue><fpage>71</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Саакян С.В., Тацков Р.А., Мякошина Е.Б., Ушакова Т.Л., Поляков В.Г., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Саакян С.В., Тацков Р.А., Мякошина Е.Б., Ушакова Т.Л., Поляков В.Г.</copyright-holder><copyright-holder xml:lang="en">Saakyan S.V., Tatskov R.A., Myakoshina E.B., Ushakova T.L., Polyakov V.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/111">https://roj.igb.ru/jour/article/view/111</self-uri><abstract><p>Цель работы - оценить эффективность транспупиллярной термотерапии (ТТТ) в лечении малых ретинобластом (РБ) с различной степенью кальцификации. Материал и методы. Представлен анализ результатов лечения 111 детей (92 глаза, 198 узлов) с малыми кальцифицированными РБ методом ТТТ. Все опухолевые очаги были разделены на 3 группы: 1-я - до 1,0 мм со слабой степенью кальцинации в виде вкрапления единичных мелких зерен (69 узлов); 2-я - от 1,1 до 2,0 мм со степенью кальцинации от мелких единичных вкраплений до занимающих 1/3 объема опухоли (61 узел); 3-я - от 2,1 до 3,0 мм с кальцинатами, выполняющими от 1/3 до 3/4 объема опухоли (68 узлов). Результаты . Установлено, что ТТТ в 1-ой группе эффективна после одного сеанса в 82,6%, во 2-ой группе - в 70,5%, в 3-ей группе - в 38,2%. Наличие в строме кальцинатов не является противопоказанием для проведения ТТТ. Заключение . Применение ТТТ в системе комбинированного органосохраняющего лечения РБ позволяет разрушать кальцифицированные опухолевые очаги, что дает возможность расширить показания к органосохраняющему лечению и во многих случаях сохранить глаз не только как косметический, но и функциональный орган. Для цитирования: Саакян С.В., Тацков Р.А., Мякошина Е.Б., Ушакова Т.Л., Поляков В.Г. Эффективность транспупиллярной термотерапии в комбинированном лечении малых кальцифицированных ретинобластом. Российский офтальмологический журнал. 2017; 10 (3): 71-77. doi: 10.21516/2072-0076-2017-10-3-71-77.</p></abstract><trans-abstract xml:lang="en"><p>Purpose: to evaluate the effectiveness of transpupillary thermotherapy (TTT) of small calcified retinoblastomas (SR) having various calcification degrees. Material and methods. The results of treatment of 111 children (92 eyes, 198 tumors) with small calcified retinoblastomas by TTT were analyzed. All tumor foci were divided into 3 groups: Group 1, with tumor size of 1.0 mm or less with a low degree of calcification in the form of small specks of single grains (69 tumors); group 2, with tumor sizes between 1.1 and 2.0 mm and calcination degrees varying from small singular inclusions to a third of tumor volume (61 tumors), and group 3, with tumor sizes between 2.1 and 3.0 with calcifications claiming from one third to three fourths of tumor volume (68 tumors). Results. TTT proved effective after one application in 82.6 % of Group 1 cases, 70.5 % of Group 2 cases, and in 38.2 % of Group 3 cases. The presence of calcinates in the tumor stroma is no contraindication for TTT. Conclusion. TTT used in combined eye preserving RB treatment destroys in most cases calcified tumor foci, and allows for an extended list of indications to eye preserving treatment, which enables the preservation of the eye not only as a cosmetic but as a functional organ. For citations: Saakyan S.V., Tatskov R.A., Myakoshina E.B., et al. Transpupillary thermotherapy efficiency in the combined treatment of small calcified retinoblastoma. Russian ophthalmological journal. 2017; 10 (3): 71-77. doi: 10.21516/2072-0076-2017-10-3-71-77 (in Russian).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ретинобластома</kwd><kwd>транспупиллярная термотерапия</kwd><kwd>оптическая когерентная томография</kwd><kwd>retinoblastoma</kwd><kwd>transpupillary thermotherapy</kwd><kwd>optical coherence tomography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бровкина А.Ф. Офтальмоонкология. Москва: Медицина; 2002.</mixed-citation><mixed-citation xml:lang="en">Бровкина А.Ф. Офтальмоонкология. Москва: Медицина; 2002.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Саакян С.В., Катаргина Л.А., Вальский В.В. и др. Федеральные клинические рекомендации «Диагностика, мониторинг и лечение детей с ретинобластомой». Российская педиатрическая офтальмология. 2015; 4: 43-8.</mixed-citation><mixed-citation xml:lang="en">Саакян С.В., Катаргина Л.А., Вальский В.В. и др. Федеральные клинические рекомендации «Диагностика, мониторинг и лечение детей с ретинобластомой». Российская педиатрическая офтальмология. 2015; 4: 43-8.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Поляков В.Г. Ретинобластома. В кн.: Национальное руководство «Онкология». Москва: ГЕОТАР-Медиа; 2008: 984-9.</mixed-citation><mixed-citation xml:lang="en">Поляков В.Г. Ретинобластома. В кн.: Национальное руководство «Онкология». Москва: ГЕОТАР-Медиа; 2008: 984-9.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Саакян С.В. Современные подходы к лечению ретинобластомы. Российский офтальмологический журнал. 2008; 1(1): 33-8.</mixed-citation><mixed-citation xml:lang="en">Саакян С.В. Современные подходы к лечению ретинобластомы. Российский офтальмологический журнал. 2008; 1(1): 33-8.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Саакян С.В., Тацков Р.А., Мякошина Е.Б. Начальная ретинобластома: ранняя диагностика и комбинированное органосохраняющее лечение. Вестник офтальмологии. 2012; 2: 55-60.</mixed-citation><mixed-citation xml:lang="en">Саакян С.В., Тацков Р.А., Мякошина Е.Б. Начальная ретинобластома: ранняя диагностика и комбинированное органосохраняющее лечение. Вестник офтальмологии. 2012; 2: 55-60.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Murphree A.L., Villablanca J.G., Deegan III W.F., et al. Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch. Ophthalmol. 1996; 114: 1348-56.</mixed-citation><mixed-citation xml:lang="en">Murphree A.L., Villablanca J.G., Deegan III W.F., et al. Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch. Ophthalmol. 1996; 114: 1348-56.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kaneko A. Conservative therapy of retinoblastoma using hyperthermia. CRC. 1993; 2: 178-84.</mixed-citation><mixed-citation xml:lang="en">Kaneko A. Conservative therapy of retinoblastoma using hyperthermia. CRC. 1993; 2: 178-84.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Shields С.L., Santos M.C.M., Diniz W., et al. Thermotherapy for retinoblastoma. Arch. Ophthalmol. 1999; 117: 885-93.</mixed-citation><mixed-citation xml:lang="en">Shields С.L., Santos M.C.M., Diniz W., et al. Thermotherapy for retinoblastoma. Arch. Ophthalmol. 1999; 117: 885-93.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Shields С.L., Shields J.A., De Potter P., Needle M. Bilateral macular retinoblastoma managed by chemoreduction and chemothermotherapy. Arch. Ophthalmol. 1996; 114: 1426-7. doi:10.1001/archopht.1996.01100140626025</mixed-citation><mixed-citation xml:lang="en">Shields С.L., Shields J.A., De Potter P., Needle M. Bilateral macular retinoblastoma managed by chemoreduction and chemothermotherapy. Arch. Ophthalmol. 1996; 114: 1426-7. doi:10.1001/archopht.1996.01100140626025</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Shields С.L., Shields J.A., Needle M., et al. Combined chemoreduction and adjuvant treatment for intraocular retinoblastoma. Ophthalmology.1997; 104: 2101-11. https://doi.org/10.1016/S0161-6420(97)30053-0</mixed-citation><mixed-citation xml:lang="en">Shields С.L., Shields J.A., Needle M., et al. Combined chemoreduction and adjuvant treatment for intraocular retinoblastoma. Ophthalmology.1997; 104: 2101-11. https://doi.org/10.1016/S0161-6420(97)30053-0</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Shields С.L., De Potter P., Himelstein B.P., et al. Chemoreduction in the initial management of intraocular retinoblastoma. Arch. Ophthalmol. 1996; 114: 1330-8. doi:10.1001/archopht.1996.01100140530002</mixed-citation><mixed-citation xml:lang="en">Shields С.L., De Potter P., Himelstein B.P., et al. Chemoreduction in the initial management of intraocular retinoblastoma. Arch. Ophthalmol. 1996; 114: 1330-8. doi:10.1001/archopht.1996.01100140530002</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Shields С.L., Mashayekhi A., Cater J., et al. Macular retinoblastoma managed with chemoreduction. Arch. Ophthalmol. 2005; 123: 765-73. doi:10.1001/archopht.123.6.765</mixed-citation><mixed-citation xml:lang="en">Shields С.L., Mashayekhi A., Cater J., et al. Macular retinoblastoma managed with chemoreduction. Arch. Ophthalmol. 2005; 123: 765-73. doi:10.1001/archopht.123.6.765</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Abramson D.H., Schefler A.C. Transpupillary thermotherapy as initial treatment for small intraocular retinoblastoma: technique and predictors of success. Ophthalmology. 2004; 111(5): 984-91. https://doi.org/10.1016/j.ophtha.2003.08.035</mixed-citation><mixed-citation xml:lang="en">Abramson D.H., Schefler A.C. Transpupillary thermotherapy as initial treatment for small intraocular retinoblastoma: technique and predictors of success. Ophthalmology. 2004; 111(5): 984-91. https://doi.org/10.1016/j.ophtha.2003.08.035</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rootman D.B. Hand-held high-resolution spectral domain optical coherence tomography in retinoblastoma: clinical and morphologic considerations. Br. J. Ophthalmol. 2013; 97(1): 59-65. doi: 10.1136/bjophthalmol-2012-302133</mixed-citation><mixed-citation xml:lang="en">Rootman D.B. Hand-held high-resolution spectral domain optical coherence tomography in retinoblastoma: clinical and morphologic considerations. Br. J. Ophthalmol. 2013; 97(1): 59-65. doi: 10.1136/bjophthalmol-2012-302133</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gombos D.S., Kelly A., Coen P.G., et al. Retinoblastoma treated with primary chemotherapy alone: the significance of tumor size, location and age. Br. J. Ophthalmol. 2002; 86: 80-3. http://dx.doi.org/10.1136/bjo.86.1.80</mixed-citation><mixed-citation xml:lang="en">Gombos D.S., Kelly A., Coen P.G., et al. Retinoblastoma treated with primary chemotherapy alone: the significance of tumor size, location and age. Br. J. Ophthalmol. 2002; 86: 80-3. http://dx.doi.org/10.1136/bjo.86.1.80</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lagendijk J. Microwave applicator for hyperthermic treatment of retinoblastoma. Natl. Cancer. Institite Monogr.1982; 61: 469-71.</mixed-citation><mixed-citation xml:lang="en">Lagendijk J. Microwave applicator for hyperthermic treatment of retinoblastoma. Natl. Cancer. Institite Monogr.1982; 61: 469-71.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Murray T.G., O`Brien J.M., Steeves R.A., et al. Radiation therapy and ferromagnetic hyperthermia in the treatment of murine transgenic retinoblastoma. Arch. Ophthalmol. 1996; 114:1376-81. doi:10.1001/archopht.1996.01100140585010</mixed-citation><mixed-citation xml:lang="en">Murray T.G., O`Brien J.M., Steeves R.A., et al. Radiation therapy and ferromagnetic hyperthermia in the treatment of murine transgenic retinoblastoma. Arch. Ophthalmol. 1996; 114:1376-81. doi:10.1001/archopht.1996.01100140585010</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Levy J., Frenkel S., Baras M., Neufeld M., Pe'er J. Calcification in retinoblastoma: histopathologic findings and statistical analysis of 302 cases. Br. J. Ophthalmol. 2011; 95(8): 1145-50. doi: 10.1136/bjo.2010.193961</mixed-citation><mixed-citation xml:lang="en">Levy J., Frenkel S., Baras M., Neufeld M., Pe'er J. Calcification in retinoblastoma: histopathologic findings and statistical analysis of 302 cases. Br. J. Ophthalmol. 2011; 95(8): 1145-50. doi: 10.1136/bjo.2010.193961</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Trump B.F., Berezesky I.K., Laiho K.U., et al. The role of calcium in cell injury. A review. Scan. Electron Microsc. 1980; 2:437.</mixed-citation><mixed-citation xml:lang="en">Trump B.F., Berezesky I.K., Laiho K.U., et al. The role of calcium in cell injury. A review. Scan. Electron Microsc. 1980; 2:437.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Carafoli E., Crompton M. The regulation of intracellular calcium by mitochondria. Ann. N.Y. Acad. Sci. 1978; 307:269. doi: 10.1111/j.1749-6632.1978.tb41957.x</mixed-citation><mixed-citation xml:lang="en">Carafoli E., Crompton M. The regulation of intracellular calcium by mitochondria. Ann. N.Y. Acad. Sci. 1978; 307:269. doi: 10.1111/j.1749-6632.1978.tb41957.x</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bygrave F.L. Mitochondria and the control of intracellular calcium. Biol. Rev. 1978; 53: 43. doi: 10.1111/j.1469-185X.1978.tb00992.x</mixed-citation><mixed-citation xml:lang="en">Bygrave F.L. Mitochondria and the control of intracellular calcium. Biol. Rev. 1978; 53: 43. doi: 10.1111/j.1469-185X.1978.tb00992.x</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
