helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2023-16-2-160-165helmholtzeyeinstitute-1250Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSМодифицирующее лечение дегенеративных заболеваний сетчатки. Часть 1. Адаптивная и неадаптивная пластичность сетчаткиModifying treatment of degenerative retinal diseases. Part 1. Adaptive and non-adaptive retinal plasticityhttps://orcid.org/0000-0002-0161-5010ЗуеваМ. В.ZuevaM. V.

Марина Владимировна Зуева, д-р биол. наук, профессор, начальник отдела клинической физиологии зрения им. С.В. Кравкова,

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Marina V. Zueva, Dr. of Biol. Sci., professor, head of the department of clinical physiology of vision named after S.V. Kravkov,

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

visionlab@yandex.ruhttps://orcid.org/0000-0002-8480-0894НероеваН. В.NeroevaN. V.

Наталия Владимировна Нероева, канд. мед. наук, врач-офтальмолог отдела патологии сетчатки и зрительного нерва, 

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Natalia V. Neroeva, Cand. of Med. Sci., ophthalmologist, department of pathology of the retina and optic nerve, 

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

https://orcid.org/0000-0002-4857-0374КатаргинаЛ. А.KatarginaL. A.

Людмила Анатольевна Катаргина, д-р мед. наук, профессор, начальник отдела патологии глаз у детей, 

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Lyudmila A. Katargina, Dr. of Med. Sci., professor, head of the department of eye pathology in children,

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

https://orcid.org/0000-0001-8381-2124ЖуравлеваА. Н.ZhuravlevaA. N.

Анастасия Николаевна Журавлева, канд. мед. наук, научный сотрудник отдела  глаукомы, 

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Anastasia N. Zhuravleva, Cand. of Med. Sci., researcher, glaucoma department, 

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

https://orcid.org/0000-0003-4675-9648КотелинВ. И.KotelinV. I.

Владислав Игоревич Котелин, канд. мед. наук, научный сотрудник отдела клинической физиологии зрения им. С.В. Кравкова, 

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Vladislav I. Kotelin, Cand. of Med. Sci., researcher, department of clinical physiology of vision named after S.V. Kravkov,

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

https://orcid.org/0000-0002-0148-8517ЦапенкоИ. В.TsapenkoI. V.

Ирина Владимировна Цапенко, канд. биол. наук, главный специалист отдела клинической физиологии зрения им. С.В. Кравкова,

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Irina V. Tsapenko, Cand. of Biol. Sci., chief specialist of the department of clinical physiology of vision named after S.V. Kravkov,

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

https://orcid.org/0000-0003-1858-2005ФадеевД. В.FadeevD. V.

Денис Владимирович Фадеев, научный сотрудник научного экспериментального  центра, 

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Denis V. Fadeev, researcher, scientific experimental center,

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

ФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииРоссияHelmholtz National Medical Research Center of Eye DiseasesRussian Federation202302072023162160165Copyright © Зуева М.В., Нероева Н.В., Катаргина Л.А., Журавлева А.Н., Котелин В.И., Цапенко И.В., Фадеев Д.В., 20232023Зуева М.В., Нероева Н.В., Катаргина Л.А., Журавлева А.Н., Котелин В.И., Цапенко И.В., Фадеев Д.В.Zueva M.V., Neroeva N.V., Katargina L.A., Zhuravleva A.N., Kotelin V.I., Tsapenko I.V., Fadeev D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/1250

Структурная пластичность сетчатки проявляется при ее повреждении различной природы, ответ на которое во многих случаях идентичен на клеточном и молекулярном уровне, включает сходный набор клеточных сигналов и ассоциируется с изменением структуры сетчатки и ремоделированием схемы нейронных соединений. В обзоре обсуждаются общие признаки и специфические особенности адаптивной и неадаптивной ретинальной пластичности, характеризующие такие заболевания, как глаукома, возрастная макулярная дегенерация, пигментный ретинит, диабетическая ретинопатия и ретинопатия недоношенных. С учетом общности признаков нейродегенерации и ретинальной пластичности при заболеваниях головного мозга и сетчатки для сохранения связности структуры и функции сетчатки во многих случаях могут применяться сходные терапевтические стратегии, которые останавливают или замедляют клиническую эволюцию заболевания либо путем подавления первичных событий, либо путем усиления компенсаторных и регенеративных механизмов в нервной ткани. Во 2-й части обзора будут представлены методы модифицирующей терапии дегенеративных заболеваний сетчатки, основанные на нейропластичности.

Retinal structural plasticity is manifested in multiple damages of the retina. In many cases, the response to these damages is identical at both the cellular and molecular levels, involves similar sets of cellular signals, and is associated with a change in the structure of the retina and remodeling of the neural connections. The review discusses the common and specific features of adaptive and non-adaptive retinal plasticity, which characterize glaucoma, age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, and retinopathy of prematurity. Given the common features of neurodegeneration and retinal plasticity in brain and retinal diseases, similar therapeutic strategies can be used in many cases to preserve the structure connectivity and retinal function, which stop or slow down the clinical evolution of the disease by either suppressing primary events or enhancing compensatory and regenerative mechanisms in the nervous tissue. Part 2 of the review will present neuroplasticity-based modifying therapy methods for retinal degenerative diseases.

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The authors declare that there are no conflicts of interest present.