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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2018-11-2-95-101</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-161</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>БЕСКОНСЕРВАНТНАЯ ФОРМА ФИКСИРОВАННОЙ КОМБИНАЦИИ БИМАТОПРОСТА И ТИМОЛОЛА В ПОВЫШЕНИИ КОМПЛАЕНСА И ЭФФЕКТИВНОСТИ ЛЕЧЕНИЯ ПАЦИЕНТОВ С ПЕРВИЧНОЙ ОТКРЫТОУГОЛЬНОЙ ГЛАУКОМОЙ</article-title><trans-title-group xml:lang="en"><trans-title>PRESERVATIVE-FREE FIXED COMBINATION OF BIMATOPROST AND TIMOLOL IN THE EVOLUTION OF COMPLIANCE AND TREATMENT EFFECTIVENESS IN PATIENTS WITH PRIMARY OPEN-ANGLE GLAUCOMA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лоскутов</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Loskoutov</surname><given-names>I. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корнеева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korneeva</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Офтальмологическое отделение Научно-практического центра ООО «РЖД», Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific and clinical center of Russian railways, 84, Moscow, Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО «Три-З», Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tri-Z Clinical Centre, Moscow, Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2018</year></pub-date><volume>11</volume><issue>2</issue><fpage>95</fpage><lpage>101</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лоскутов И.А., Корнеева А.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Лоскутов И.А., Корнеева А.В.</copyright-holder><copyright-holder xml:lang="en">Loskoutov I.A., Korneeva A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/161">https://roj.igb.ru/jour/article/view/161</self-uri><abstract><p>Цель обзора - анализ данных новейших клинических исследований эффективности и безопасности фиксированных комбинаций как средства первоочередного выбора в терапии пациентов с первичной открытоугольной глаукомой. Анализируются данные о применении фиксированной комбинации биматопроста 0,03% и тимолола 0,5%, а также влияние применения данной фиксированной комбинации без консерванта на повышение приверженности к лечению, сохранение зрительных функций и повышение качества жизни пациентов на всех стадиях глаукомного процесса. Для цитирования: Лоскутов И.А., Корнеева А.В. Бесконсервантная форма фиксированной комбинации биматопроста и тимолола в повышении комплаенса и эффективности лечения пациентов с первичной открытоугольной глаукомой. Российский офтальмологический журнал. 2018; 11(2): 95-101. doi: 10.21516/2072-0076-2018-11-2-95-101.</p></abstract><trans-abstract xml:lang="en"><p>The purpose of the review is to analyze the recent clinical research data concerning the efficacy and safety of fixed combinations as a first-choice therapy of patients with all stages of primary open-angle glaucoma. Application results of a fixed combination of Bimatoprost 0.03 % and Timolol 0.5 % are analyzed. The impact of preservative-free fixed combination usage on increasing the compliance, protection of visual functions and improving life quality at different stages of the glaucomatous process. For citation: Loskoutov I.A., Korneeva A.V. Preservative-free fixed combination of Bimatoprost and Timolol in the evolution of compliance and treatment effectiveness in patients with primary open-angle glaucoma. Russian ophthalmological journal. 2018; 11 (2): 95-101. doi: 10.21516/2072-0076-2018-11-2-95-101 (In Russian).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>первичная открытоугольная глаукома</kwd><kwd>биматопрост</kwd><kwd>тимолол</kwd><kwd>фиксированная комбинация</kwd><kwd>бесконсервантная форма</kwd><kwd>primary open-angle glaucoma</kwd><kwd>Bimatoprost</kwd><kwd>Timolol</kwd><kwd>preservative-free fixed combination</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Freeman E.E., Munoz B., West S.K., Jampel H.D., Friedman D.S. Glaucoma and quality of life: the Salisbury eye evaluation. Ophthalmol. 2008; 115(2): 233-38. doi.org/10.1016/j.ophtha.2007.04.050</mixed-citation><mixed-citation xml:lang="en">Freeman E.E., Munoz B., West S.K., Jampel H.D., Friedman D.S. Glaucoma and quality of life: the Salisbury eye evaluation. 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