helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2024-17-4-116-120helmholtzeyeinstitute-1633Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSИзбыточное рубцевание в хирургии глаукомы. Часть 1. Морфология рубцового процессаWound healing in glaucoma surgery. Part 1. Wound healing morphologyhttps://orcid.org/0000-0002-4713-5661ИзмайловаН. С.IzmailovaN. S.

Наталья Сергеевна Измайлова — начальник отдела патологической анатомии и гистологии, ведущий научный сотрудник, врач-патологоанатом.

Ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Natalia S. Izmailova — head of the department of pathological fnatomy and histology, leading researcher, pathologist.

14/19, Sadovaya- Chernogryazskaya St., Moscow, 105062

https://orcid.org/0000-0001-6922-0464ПетровС. Ю.PetrovS. Yu.

Сергей Юрьевич Петров — д-р мед. наук, начальник отдела глаукомы.

Ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Sergey Yu. Petrov — Dr. of Med. Sci., head of glaucoma department.

14/19, Sadovaya- Chernogryazskaya St., Moscow, 105062

glaucomatosis@gmail.comДзебисоваА. Д.DzebisovaA. D.

Анжела Давидовна Дзебисова — аспирант отдела глаукомы.

Ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Angela D. Dzebisova — PhD student, glaucoma department.

14/19, Sadovaya- Chernogryazskaya St., Moscow, 105062

 

ФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииРоссияHelmholtz National Medical Research Center of Eye DiseasesRussian Federation202414122024174116120Copyright © Измайлова Н.С., Петров С.Ю., Дзебисова А.Д., 20242024Измайлова Н.С., Петров С.Ю., Дзебисова А.Д.Izmailova N.S., Petrov S.Y., Dzebisova A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/1633

Глаукома является актуальной проблемой офтальмологии и ведущей причиной слепоты в мире. Доказанным условием предотвращения прогрессирования глаукомной оптической нейропатии является снижение внутриглазного давления. Терапию начинают с местных гипотензивных препаратов, при их недостаточной эффективности проводят лазерное лечение или прибегают к хирургии. Однако проведение гипотензивного вмешательства не гарантирует достижения стойкого гипотензивного эффекта. Заживление ран является сложным физиологическим динамическим процессом, который необходим для поддержания гомеостаза в организме. В этом процессе выделяют три связанные между собою фазы: воспаление, фиброплазию и ремодуляцию (созревание) рубца. В обзоре представлены различные клеточные механизмы, участвующие в регуляции данных процессов и способствующие избыточному рубцеванию. Современные знания о ключевых факторах патоморфологических процессов, происходящих в области фильтрационной зоны, призваны стимулировать разработку новых методов пролонгации действия фильтрующей хирургии.

Glaucoma is a leading cause of blindness in the world. A proven condition for preventing the progression of glaucomatous optic neuropathy is to reduce intraocular pressure. Therapy begins with local hypotensive drugs; if they are ineffective, laser treatment or surgery is used. However, hypotensive intervention does not guarantee a stable hypotensive effect. Wound healing is a complex physiological dynamic process that is necessary to maintain homeostasis in the body. This process includes three interrelated phases: inflammation, fibroplasia, and remodulation (maturation) of the scar. Thе review presents various cellular mechanisms involved in the regulation of these processes and factors that contribute to excessive scarring. The review presents various cellular mechanisms involved in the regulation of these processes and contributing to excessive scarring. Current knowledge about the key factors of pathomorphological processes occurring in the filtration zone is intended to stimulate the development of new methods for prolonging the effect of filtering surgery.

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The authors declare that there are no conflicts of interest present.