helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2018-11-3-101-106helmholtzeyeinstitute-177Research ArticleСтатьиArticlesМОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ ПОВРЕЖДЕНИЯ ЗРИТЕЛЬНОГО НЕРВА: РОЛЬ АНТОЦИАНОЗИДОВ В ПРОФИЛАКТИКЕ ГИБЕЛИ ГАНГЛИОЗНЫХ КЛЕТОКMOLECULAR MECHANISMS OF OPTIC NERVE DAMAGE: THE ROLE OF ANTHOCYANOZIDES IN THE PREVENTION OF RETINAL GANGLION CELL DEATHНероевВ. В.NeroevV. V.noemail@neicon.ruКиселёваТ. Н.KiselevaT. N.noemail@neicon.ruЗайцевМ. С.ZaitsevÌ. S.noemail@neicon.ruФГБУ «Московский НИИ глазных болезней им. Гельмгольца» Минздрава РоссииРоссияMoscow Helmholtz Research Institute of Eye Diseases, RussiaRussian Federation201803102018113101106Copyright © Нероев В.В., Киселёва Т.Н., Зайцев М.С., 20182018Нероев В.В., Киселёва Т.Н., Зайцев М.С.Neroev V.V., Kiseleva T.N., Zaitsev Ì.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/177

В обзоре представлены сведения о дисфункции эндоплазматического ретикулума (ЭПР), роли стресса ЭПР и окислительного стресса в патогенезе заболеваний зрительного нерва. Приводятся данные о молекулярных механизмах повреждения зрительного нерва, включающего экспрессию генов и молекулярных шаперонов, связанных со стрессом ЭПР и антиоксидантной защитой. Результаты изучения эффектов перорального применения антоцианозидов экстракта черники показали увеличение уровня молекулярных шаперонов в ганглиозных клетках сетчатки, подавляющих стресс ЭПР и оказывающих положительное влияние на метаболическую активность клеток. Антоцианозиды экстракта черники могут рассматриваться в качестве нейропротекторов в комплексном лечении пациентов с патологией сетчатки и глаукомой. Для цитирования: Нероев В.В., Киселёва Т.Н., Зайцев М.С. Молекулярные механизмы повреждения зрительного нерва: роль антоцианозидов в профилактике гибели ганглиозных клеток. Российский офтальмологический журнал. 2018; 11(3):107-112. doi: 10.21516/2072-0076-2018-11-3-101-106

The literary review focuses on the dysfunction of endoplasmic reticulum (EPR), the role of EPR stress and oxidative stress in the pathogenesis of optic nerve damage. The data on the molecular mechanisms of optic nerve damage are given: these include the expression of genes and molecular chaperones, which are related to EPR stress and antioxidant protection. The studies into oral administration of bilberry extract anthocyanosides showed elevated levels of molecular chaperones in retinal ganglion cells (RGC). The chaperones suppress EPR stress and produce a positive effect on the metabolic activity of the cells. Thus, bilberry extract anthocyanosides may be considered as neuroprotectors in combined treatment of retinal pathology and glaucoma. For citation: Neroev V.V., Kiseleva T.N., Zaitsev М.S. Molecular mechanisms of optic nerve damage: the role of anthocyanozides in the prevention of retinal ganglion cell death. Russian ophthalmological journal. 2018; 11 (3): 101-6 (In Russian). doi: 10.21516/2072-0076-2018-11-3-101-106

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The authors declare that there are no conflicts of interest present.