helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2025-18-2-102-107helmholtzeyeinstitute-1801Research ArticleКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯCLINICAL STUDIESСлой нервных волокон сетчатки при большой бета-талассемии: сравнительное исследованиеRetinal nerve fiber layer in beta-thalassemia major: a comparative studyФирдоусМ.FirdousM.

Фирдоус Мариам — старший преподаватель кафедры медицинских наук.

Висма Линкольн, № 12– 18, Джалан СС 6/12, 47301, Петалинг Джая, Селангор Дарул Эхсан

Maryam Firdous — senior lecturer, department of health sciences.

Wisma Lincoln, No. 12–18, Jalan SS 6/12, 47301, Petaling Jaya, Selangor Darul Ehsan

https://orcid.org/0000-0001-7779-1929УмерМ. Ф.UmerM. F.

Умер Мухаммад Фарук — доцент, кафедра профилактической стоматологии.

31982, Хуфуф, Аль-Ахса

Muhammad Farooq Umer — assistant professor, department of preventive dental sciences.

31982, Hofuf, Al-Ahsa

https://orcid.org/0000-0001-6904-7980ЧандранС. П.ChandranS. P.

Чандра Суриякала Перумал — руководитель отдела, факультет медицинских наук.

Висма Линкольн, № 12– 18, Джалан СС 6/12, 47301, Петалинг Джая, Селангор Дарул Эхсан

Suriyakala Perumal Chandran — head of the department, faculty of medicines.

Wisma Lincoln, No. 12–18, Jalan SS 6/12, 47301, Petaling Jaya, Selangor Darul Ehsan

suriyakala@lincoln.edu.myФакультет медицинских наук, Университетский колледж ЛинкольнаМалайзияLincoln University CollegeMalaysiaКолледж стоматологии, Университет короля ФейсалаСаудовская АравияCollege of Dentistry, King Faisal UniversitySaudi Arabia202514062025182102107Copyright © Фирдоус М., Умер М.Ф., Чандран С.П., 20252025Фирдоус М., Умер М.Ф., Чандран С.П.Firdous M., Umer M.F., Chandran S.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/1801

Бета-талассемия — наследственное заболевание крови, возникающее из-за дефектного синтеза гена бета-глобина. Характеризуется дефицитом крови, обусловленным неэффективным эритропоэзом, гемолизом и повышенным уровнем железа вследствие повторных трансфузий. Цель исследования — оценить изменения толщины слоя нервных волокон сетчатки (СНВС) при большой бета-талассемии в сравнении со здоровыми людьми. Материал и методы. Поперечное исследование, проведенное в период с декабря 2023 г. по июнь 2024 г., включало 56 случаев тяжелой бета-талассемии и 64 здоровых человека. Средний возраст больных (18,42 ± 4,05 года) и лиц контрольной группы (17,45 ± 4,02 года) был практически одинаковым (p = 0,190). Всем проведено стандартное офтальмологическое обследование, а также измерение толщины СНВС с использованием оптической когерентной томографии (Heidelberg Spectralis). Результаты. Толщина СНВС значительно различалась в основной и контрольной группе. Значение p для общей, нижней, назальной и височной толщины СНВС составляло < 0,001, тогда как значение p для СНВС верхнего отдела составляло 0,006. Обнаружена значительная корреляция показателей глобальной толщины, а также толщины нижнего и назального СНВС с продолжительностью талассемии (p = 0,01, p = 0,01, p < 0,001). Значения глобальной и назальной толщины СНВС оказались ниже при монотерапии хелаторами железа (p = 0,048, p = 0,006). Заключение. СНВС при большой бета-талассемии значительно тоньше, чем у здоровых людей. Глобальная толщина и толщина СНВС в нижней и назальной области значимо коррелировали с продолжительностью талассемии и с терапией хелатированием железа.

Beta-thalassemia is a hereditary blood disorder which occurs due to defective beta-globin gene synthesis. It is characterized by blood deficiency caused by ineffective erythropoiesis, hemolysis, and iron overload due to repeated transfusions. The purpose of the is study to find out the changes in retinal nerve fiber layer (RNFL) thickness as a result of Beta-thalassemia major and to compare the values with healthy individuals. Material and methods. This cross-sectional study was performed on a total of 56 beta-thalassemia major cases and 64 healthy controls from December 2023 to June 2024. The mean age of the cases (18.42 ± 4.05 years) and controls (17.45 ± 4.02 years) was significantly similar (p = 0.190). All the subjects undergone standard ophthalmological examination followed by RNFL thickness measurement using Heidelberg Spectralis OCT (Optical Coherence Tomography). Results. The RNFL thickness showed significant difference between the case and control groups. The p-value for global, inferior, nasal, and temporal RNFL thickness was < 0.001, while for superior RNFL p-value was 0.006. A significant correlation of global, inferior, and nasal RNFL measurements was found with the duration of thalassemia (p = 0.01, p = 0.01, p < 0.001), however, the global and nasal RNFL were found to be thinner in the cases receiving iron chelation monotherapy (p = 0.048, p = 0.006). Conclusion. The study concludes that the RNFL was significantly thinner in beta-thalassemia major cases in comparison to healthy controls. Moreover, only global, inferior, and nasal RNFL revealed to have a significant correlation with the thalassemia duration and iron chelation therapy.

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The authors declare that there are no conflicts of interest present.