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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2025-18-3-15-22</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-1872</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Ретинопатия недоношенных у взрослых пациентов: клинические исходы и осложнения</article-title><trans-title-group xml:lang="en"><trans-title>Retinopathy of prematurity in adult patients: clinical outcomes and complications</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2768-0443</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коголева</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kogoleva</surname><given-names>V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Людмила Викторовна Коголева — д-р мед. наук, заведующая детским консультативно-поликлиническим отделением</p><p>ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Lyudmila V. Kogoleva — Dr. of Med. Sci., head of children's consultating outpatient department</p><p>14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захарова</surname><given-names>Г. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharova</surname><given-names>G. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галина Юрьевна Захарова — канд. мед. наук, ведущий научный сотрудник отдела патологии сетчатки и зрительного нерва</p><p>ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Galina Yu. Zakharova — Cand. of Med. Sci., leading researcher of retinal and optic nerve pathology department</p><p>14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-0946-4105</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пак</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pak</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Владимировна Пак — канд. мед. наук, заведующая взрослым консультативно-поликлиническим отделением</p><p>ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Natalia V. Pak — Cand. of Med. Sci., head of adult consultating outpatient department</p><p>14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-2733-6470</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беляев</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Belyaev</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитрий Сергеевич Беляев — врач-офтальмолог взрослого консультативно-поликлинического отделения</p><p>ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Dmitry S. Belyaev — ophthalmologist of adult consultating outpatient department</p><p>14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-6977-8293</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Николаевна Егорова — врач-офтальмолог взрослого консультативно-поликлинического отделения</p><p>ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Elena N. Egorova — ophthalmologist of adult consultating outpatient department</p><p>14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6465-2313</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Викторовна Белова — канд. мед. наук, врач-офтальмолог офтальмологического отделения детской хирургии</p><p>ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Maria V. Belova — Cand. of Med Sci., ophthalmologist of pediatric surgery department</p><p>14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2927-4446</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кокоева</surname><given-names>Н. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Kokoeva</surname><given-names>N. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нина Шотаевна Кокоева — врач-офтальмолог детского консультативно-поликлинического отделения</p><p>ул. Садовая-Черногрязская, д. 14/19, Москва, 105062</p></bio><bio xml:lang="en"><p>Nina S. Kokoeva — ophthalmologist of children's consultating outpatient department </p><p>14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062</p></bio><email xlink:type="simple">ninoofta@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Helmholtz National Medical Research Center of Eye Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>09</month><year>2025</year></pub-date><volume>18</volume><issue>3</issue><fpage>15</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коголева Л.В., Захарова Г.Ю., Пак Н.В., Беляев Д.С., Егорова Е.Н., Белова М.В., Кокоева Н.Ш., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Коголева Л.В., Захарова Г.Ю., Пак Н.В., Беляев Д.С., Егорова Е.Н., Белова М.В., Кокоева Н.Ш.</copyright-holder><copyright-holder xml:lang="en">Коголева Л.В., Zakharova G.Y., Pak N.V., Belyaev D.S., Egorova E.N., Belova M.V., Kokoeva N.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/1872">https://roj.igb.ru/jour/article/view/1872</self-uri><abstract><p>Цель работы — изучить клинико-функциональное состояние глаз и осложнения ретинопатии недоношенных (РН) у пациентов старше 18 лет.</p><sec><title>Материал и методы</title><p>Материал и методы. Обследовано 66 пациентов в возрасте 18–35 лет (в среднем 22,68 ± 0,58 года) с рубцовой РН. Комплексное офтальмологическое обследование включало стандартные методы (визометрия, рефрактометрия, тонометрия, биомикроскопия, офтальмоскопия), а также компьютерную периметрию, электрофизиологические и ультразвуковые исследования, оптическую когерентную томографию и др. (по показаниям).</p></sec><sec><title>Результаты</title><p>Результаты. Благоприятные исходы (остаточные изменения рубцовой РН I–III степени) диагностированы в 78% глаз, неблагоприятные (рубцовая РН IV–V степени) — в 22%. В большинстве случаев (73,5%) острота зрения была снижена. Аномалии рефракции выявлены в 97% случаев, из них в 78% глаз — миопия средней и высокой степени. Поздние осложнения развились в 59,85% случаев, наиболее часто выявлялись периферические ретинальные дистрофии — 55,7%, отслойка сетчатки — 16,5%, осложненная катаракта — 11,4%, вторичная глаукома — 3,8%. Способ лечения определялся в зависимости от клинической картины и тяжести осложнений.</p></sec><sec><title>Заключение</title><p>Заключение. Все пациенты, перенесшие РН в неонатальном возрасте, независимо от того, произошел ли самопроизвольный регресс заболевания или проводилось лечение (коагуляция сетчатки, интравитреальное введение ингибиторов ангиогенеза, микрохирургические вмешательства), должны пожизненно и регулярно наблюдаться у офтальмолога. Необходимо проводить тщательное комплексное обследование переднего и заднего отделов глаза с целью раннего выявления и своевременного лечения поздних осложнений РН.</p></sec></abstract><trans-abstract xml:lang="en"><p>The aim of the work is to study the clinical and functional state of the eyes and complications of ROP in patients over 18 years old who applied to the Center.</p><sec><title>Material and methods</title><p>Material and methods. 66 young adults from 18 to 35 years old (on average, 22.68 ± 0.58 years) with cicatricial retinopathy of prematurity were examined. All patients underwent a comprehensive ophthalmological examination, including standard methods (visometry, refractometry, tonometry, biomicroscopy, ophthalmoscopy), as well as computer perimetry, EPS, ultrasound, optical coherence tomography, etc. (as indicated).</p></sec><sec><title>Results</title><p>Results. Favorable outcomes (residual changes in cicatricial RP of I–III degree) were diagnosed in 78% of eyes, unfavorable (cicatricial RP of IV–V degree) — in 22%. In most cases, visual acuity was reduced — 73,5%. Refractive anomalies were detected in 97%, of which 78% were moderate and high myopia. Late complications developed in 59.8% of cases: peripheral retinal dystrophies — 55.7%, retinal detachment — 16.5%, complicated cataract — 11.4%, secondary glaucoma — 3.8%, etc. Treatment depended on the type and severity of complications.</p></sec><sec><title>Conclusion</title><p>Conclusion. All patients who had ROP in neonatal age, regardless of whether there was spontaneous regression of the disease or treatment (retinal coagulation, intravitreal administration of angiogenesis inhibitors, microsurgical interventions), should be monitored by an ophthalmologist for life and regularly. It is necessary to conduct a thorough, comprehensive examination of the anterior and posterior segments of the eye, for the purpose of early detection and timely treatment of late complications.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рубцовая ретинопатия недоношенных</kwd><kwd>осложнения</kwd><kwd>взрослые</kwd><kwd>диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cicatricial retinopathy of prematurity</kwd><kwd>complications</kwd><kwd>adults</kwd><kwd>diagnostics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Нероев В.В., Катаргина Л.А., Коголева Л.В. Профилактика слепоты и слабо видения у детей с ретинопатией недоношенных. Вопросы современной педиатрии. 2015; 14 (2): 265–70.</mixed-citation><mixed-citation xml:lang="en">Neroev V.V., Katargina L.A., Kogoleva L.V. 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