helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2025-18-3-152-157helmholtzeyeinstitute-1893Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSИзбыточное рубцевание в хирургии глаукомы. Часть 4. Методы послеоперационной профилактикиWound healing in glaucoma surgery. Part 4. Postoperative methodshttps://orcid.org/0000-0001-6922-0464ПетровС. Ю.PetrovS. Yu.

Сергей Юрьевич Петров — д-р мед. наук, начальник отдела глаукомы

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Sergey Yu. Petrov — Dr. of Med. Sci., head of glaucoma department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

glaucomatosis@gmail.comhttps://orcid.org/0000-0001-9082-4537ФилипповаО. М.FilippovaO. M.

Ольга Маратовна Филиппова — канд. мед. наук, научный сотрудник отдела глаукомы

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Olga M. Filippova — Cand. of Med. Sci., researcher, glaucoma department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

https://orcid.org/0009-0006-8100-9681ЕпхиеваА. Д.EpkhievaA. D.

Анжела Давидовна Епхиева — аспирант

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Anzhela D. Epkhieva — graduate student of glaucoma department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

ФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииРоссияHelmholtz National Medical Research Center of Eye DiseasesRussian Federation202517092025183152157Copyright © Петров С.Ю., Филиппова О.М., Епхиева А.Д., 20252025Петров С.Ю., Филиппова О.М., Епхиева А.Д.Petrov S.Y., Filippova O.M., Epkhieva A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/1893

Антиглаукомная хирургия в настоящее время является наиболее эффективным методом снижения внутриглазного давления. Однако процессы избыточного рубцевания в зоне операции препятствуют нормализации оттока внутриглазной жидкости, что снижает отдаленную эффективность хирургического вмешательства. Высокоэффективным методом профилактики рубцевания является применение цитостатических препаратов, однако отсутствие официальных показаний для их использования и значимые побочные эффекты ограничивают их применение. В настоящее время насчитывается более трех десятков различных методик интраи послеоперационной противорубцовой терапии, включающих цитостатические, противовоспалительные, антиангиогенные и антинеопластические препараты, а также применение β-радиации и кросслинкинга.

Glaucoma surgery is currently the most effective method of intraocular pressure reducing. However, the wound healing surgical area processes prevent the intraocular fluid outflow, that reduce the long-term effectiveness of the surgery. A highly effective method of preventing scarring is the use of cytostatics, however, the lack of official indications and significant side effects limit it’s use. Currently, there are more than three dozen different methods of intraand postoperative antiscar therapy, including cytostatic, anti-inflammatory, anti-angiogenic and anti-neoplastic drugs, as well as the use of β-radiation and cross-linking.

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The authors declare that there are no conflicts of interest present.