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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2025-18-4-57-61</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-1955</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Оценка изменений сосудов сетчатки и эндотелия роговицы при остром COVID-19 в постковидном периоде</article-title><trans-title-group xml:lang="en"><trans-title>Assessment of retinal vessels and corneal endothelium alterations in acute and post-COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джааз</surname><given-names>М. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Jaaz</surname><given-names>M. H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Муатаз Хасан Джааз — бакалавр медицины и хирургии, хирург и преподаватель офтальмологии, кафедра хирургии</p><p>Ти-Кар, 64001</p></bio><bio xml:lang="en"><p>Muataz Hasan Jaaz  —  M.B.CH.B, F.I.C.M.S., surgeon  and  lecturer of ophthalmology, department of surgery</p><p>Thi-Qar, 64001</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фахад</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fahad</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аммар Адиль Фахад — оптометрист, преподаватель кафедры оптики</p><p>улица Нил, Ти-Кар, 64001</p></bio><bio xml:lang="en"><p>Ammar Adil Fahad — optometrist, teaching staff, department of optics</p><p>Nile Street, Thi-Qar, 64001</p></bio><email xlink:type="simple">muatazhasan@itq.edu.iq</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Медицинский колледж, Университет Ти-Кар</institution><country>Ирак</country></aff><aff xml:lang="en"><institution>College of Medicine, University of Thi-Qar</institution><country>Iraq</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Колледж здравоохранения и медицинских технологий, Университет Аль-Айен</institution><country>Ирак</country></aff><aff xml:lang="en"><institution>College of Health and Medical Technology, Al-Ayen University</institution><country>Iraq</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>09</day><month>01</month><year>2026</year></pub-date><volume>18</volume><issue>4</issue><fpage>57</fpage><lpage>61</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Джааз М.Х., Фахад А.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Джааз М.Х., Фахад А.А.</copyright-holder><copyright-holder xml:lang="en">Jaaz M.H., Fahad A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/1955">https://roj.igb.ru/jour/article/view/1955</self-uri><abstract><p>Пандемия COVID-19, вызванная SARS-CoV-2, ассоциирована со значительными системными эффектами за пределами дыхательной системы, в том числе с офтальмологическими осложнениями.</p><p>Цель работы — оценить изменения сосудов сетчатки и эндотелия роговицы у пациентов при остром COVID-19 и в пост-ковидном периоде.</p><sec><title>Материал и методы</title><p>Материал и методы. Проспективное наблюдательное исследование, проведенное в больнице Аль-Хуссейн в Ираке в течение 2021–2022 гг., включало 50 пациентов (56 % мужчин) в возрасте 61,7 ± 12,5 года с подтвержденным с помощью ПЦР-тестирования COVID-19. Сопутствующие заболевания включали гипертонию (30 %), курение (26 %) и сахарный диабет (16 %). Проведено комплексное офтальмологическое обследование, включая ретинальную визуализацию и зеркальную микроскопию. Клинические и лабораторные данные собраны и проанализированы с использованием SPSS версии 26.0.</p></sec><sec><title>Результаты</title><p>Результаты. В период между острой и пост-острой фазами наблюдались значительные лабораторные изменения, указывающие на воспалительную реакцию. В постковидном периоде состояние сетчатки значительно улучшилось, уменьшились ретинальные кровоизлияния, извилистость сосудов и расширение вен. Зеркальная микроскопия показала улучшение в плотности и средней площади клеток, коэффициента вариации и гексагональности.</p></sec><sec><title>Заключение</title><p>Заключение. COVID-19 оказывает значительное влияние на состояние сетчатки и роговицы, при этом наблюдается заметное улучшение после инфицирования. Эти данные подчеркивают необходимость постоянного офтальмологического мониторинга пациентов с COVID-19 для диагностики и минимизации долгосрочных офтальмологических осложнений.</p></sec></abstract><trans-abstract xml:lang="en"><p>The COVID-19 pandemic, caused by SARS-CoV-2, has shown significant systemic effects beyond the respiratory system, including ophthalmologic complications.</p><p>The purpose of the study is to assess alterations in retinal vessels and corneal endothelium in patients with acute and post-COVID-19 infection.</p><sec><title>Material and methods</title><p>Material and methods. A prospective observational study was conducted at Al-Hussain Teaching Hospital in Iraq at two years 2021–2022, including 50 adult patients (56 % male) aged 61.7 ± 12.5 years with confirmed COVID-19 by PCR testing. Common comorbidities included hypertension (30 %), smoking (26 %), and diabetes mellitus (16 %). Comprehensive ophthalmologic examinations were performed, including retinal imaging and specular microscopy. Clinical and laboratory data were collected and analyzed using SPSS version 26.0.</p></sec><sec><title>Results</title><p>Results. Significant laboratory changes were observed between acute and post-acute phases, indicating an inflammatory response during acute infection. Retinal alterations improved significantly post-acute COVID-19, with reductions in retinal hemorrhage, vessels tortuosity, and veins dilatation. Specular microscopy showed improvements in cell density, average cell area, coefficient of variation, and hexagonality.</p></sec><sec><title>Conclusion</title><p>Conclusion. COVID-19 has significant impacts on retinal and corneal health, with notable improvements post-infection. These findings highlight the need for on-going ophthalmologic monitoring in COVID-19 patients to manage and mitigate long-term ocular complications.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>сосуды сетчатки</kwd><kwd>эндотелий роговицы</kwd><kwd>офтальмологические осложнения</kwd><kwd>SARS-CoV-2</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>retinal vessels</kwd><kwd>corneal endothelium</kwd><kwd>ophthalmologic complications</kwd><kwd>SARS-CoV-2</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579 (7798): 270–3. doi: 10.1038/s41586-020-2951-z</mixed-citation><mixed-citation xml:lang="en">Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579 (7798): 270–3. doi: 10.1038/s41586-020-2951-z</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Seah I, Agrawal R. Can the Coronavirus disease 2019 (COVID-19) affect the eyes? A review of Coronaviruses and ocular implications in humans and animals. Ocul Immunol Inflamm. 2020 Apr 2; 28 (3): 391–5. doi: 10.1080/09273948.2020.1738501</mixed-citation><mixed-citation xml:lang="en">Seah I, Agrawal R. Can the Coronavirus disease 2019 (COVID-19) affect the eyes? A review of Coronaviruses and ocular implications in humans and animals. Ocul Immunol Inflamm. 2020 Apr 2; 28 (3): 391–5. doi: 10.1080/09273948.2020.1738501</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ali MJ. The SARS-CoV-2, tears, and ocular surface debate: What we know and what we need to know. Indian J Ophthalmol. 2020 Jul; 68 (7): 1245–6. doi: 10.4103/ijo.IJO_1881_20</mixed-citation><mixed-citation xml:lang="en">Ali MJ. The SARS-CoV-2, tears, and ocular surface debate: What we know and what we need to know. Indian J Ophthalmol. 2020 Jul; 68 (7): 1245–6. doi: 10.4103/ijo.IJO_1881_20</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegler CGK, Allon SJ, Nyquist SK, et al. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020 May 28; 181 (5): 1016–35.e19. doi: 10.1016/j.cell.2020.04.035</mixed-citation><mixed-citation xml:lang="en">Ziegler CGK, Allon SJ, Nyquist SK, et al. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020 May 28; 181 (5): 1016–35.e19. doi: 10.1016/j.cell.2020.04.035</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Zhong Y, Wang K, Zhu Y, et al. Ocular manifestations in COVID-19 patients: A systematic review and meta-analysis. Travel Med Infect Dis. 2021 Nov-Dec; 44: 102191. doi: 10.1016/j.tmaid.2021.102191</mixed-citation><mixed-citation xml:lang="en">Zhong Y, Wang K, Zhu Y, et al. Ocular manifestations in COVID-19 patients: A systematic review and meta-analysis. Travel Med Infect Dis. 2021 Nov-Dec; 44: 102191. doi: 10.1016/j.tmaid.2021.102191</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Karimi S, Arabi A, Shahraki T, Safi S. Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019. Eye. 2020: 1220–3. https://doi.org/10.1038/s41433-020-0965-2</mixed-citation><mixed-citation xml:lang="en">Karimi S, Arabi A, Shahraki T, Safi S. Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019. Eye. 2020: 1220–3. https://doi.org/10.1038/s41433-020-0965-2</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ho D, Low R, Tong L, et al. COVID-19 and the ocular surface: a review of transmission and manifestations. Ocul Immunol Inflamm. 2020 Jul 3; 28 (5): 726–34. doi: 10.1080/09273948.2020.1772313</mixed-citation><mixed-citation xml:lang="en">Ho D, Low R, Tong L, et al. COVID-19 and the ocular surface: a review of transmission and manifestations. Ocul Immunol Inflamm. 2020 Jul 3; 28 (5): 726–34. doi: 10.1080/09273948.2020.1772313</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Aggarwal K, Agarwal A, Jaiswal N, et al. Ocular surface manifestations of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. PLoS One. 2020 Nov 5; 15 (11): e0241661. doi: 10.1371/journal.pone.0241661</mixed-citation><mixed-citation xml:lang="en">Aggarwal K, Agarwal A, Jaiswal N, et al. Ocular surface manifestations of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. PLoS One. 2020 Nov 5; 15 (11): e0241661. doi: 10.1371/journal.pone.0241661</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Sen S, Kannan NB, Kumar J, et al. Retinal manifestations in patients with SARS-CoV-2 infection and pathogenetic implications: a systematic review. Int Ophthalmol. 2021; 1–14.</mixed-citation><mixed-citation xml:lang="en">Sen S, Kannan NB, Kumar J, et al. Retinal manifestations in patients with SARS-CoV-2 infection and pathogenetic implications: a systematic review. Int Ophthalmol. 2021; 1–14.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cheema M, Aghazadeh H, Nazarali S, et al. Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19). Can J Ophthalmol. 2020 Aug; 55 (4): e125–e129. doi: 10.1016/j.jcjo.2020.03.003</mixed-citation><mixed-citation xml:lang="en">Cheema M, Aghazadeh H, Nazarali S, et al. Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19). Can J Ophthalmol. 2020 Aug; 55 (4): e125–e129. doi: 10.1016/j.jcjo.2020.03.003</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients. J Infect. 2020 Jun; 80 (6): e14–e18. doi: 10.1016/j.jinf.2020.03.005</mixed-citation><mixed-citation xml:lang="en">Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients. J Infect. 2020 Jun; 80 (6): e14–e18. doi: 10.1016/j.jinf.2020.03.005</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Invernizzi A, Schiuma M, Parrulli S, et al. Retinal vessels modifications in acute and post-COVID-19. Sci Rep. 2021; 11 (1): 19373. https://doi.org/10.1038/s41598-021-98873-1</mixed-citation><mixed-citation xml:lang="en">Invernizzi A, Schiuma M, Parrulli S, et al. Retinal vessels modifications in acute and post-COVID-19. Sci Rep. 2021; 11 (1): 19373. https://doi.org/10.1038/s41598-021-98873-1</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Modjtahedi BS, Do D, Luong TQ, et al. Changes in the incidence of retinal vascular occlusions after COVID-19 diagnosis. JAMA Ophthalmol. 2022 May 1; 140 (5): 523–7. doi: 10.1001/jamaophthalmol.2022.0632</mixed-citation><mixed-citation xml:lang="en">Modjtahedi BS, Do D, Luong TQ, et al. Changes in the incidence of retinal vascular occlusions after COVID-19 diagnosis. JAMA Ophthalmol. 2022 May 1; 140 (5): 523–7. doi: 10.1001/jamaophthalmol.2022.0632</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bwire GM. Coronavirus: Why men are more vulnerable to Covid-19 than women. SN Compr Clin Med. 2020; 2 (7): 874–6. doi: 10.1007/s42399-020-00341-w</mixed-citation><mixed-citation xml:lang="en">Bwire GM. Coronavirus: Why men are more vulnerable to Covid-19 than women. SN Compr Clin Med. 2020; 2 (7): 874–6. doi: 10.1007/s42399-020-00341-w</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020 May; 94: 91–5. doi: 10.1016/j.ijid.2020.03.017</mixed-citation><mixed-citation xml:lang="en">Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020 May; 94: 91–5. doi: 10.1016/j.ijid.2020.03.017</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Çetin Kargin N. The effect of smoking on COVID-19-linked biomarkers in hospitalized patients with COVID-19. J Clin Lab Anal. 2021 Oct; 35 (10): e23983. doi: 10.1002/jcla.23983</mixed-citation><mixed-citation xml:lang="en">Çetin Kargin N. The effect of smoking on COVID-19-linked biomarkers in hospitalized patients with COVID-19. J Clin Lab Anal. 2021 Oct; 35 (10): e23983. doi: 10.1002/jcla.23983</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wu P, Duan F, Luo C, et al. Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020 May 1; 138 (5): 575–8. doi: 10.1001/jamaophthalmol.2020.1291</mixed-citation><mixed-citation xml:lang="en">Wu P, Duan F, Luo C, et al. Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020 May 1; 138 (5): 575–8. doi: 10.1001/jamaophthalmol.2020.1291</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Casagrande M, Fitzek A, Puschel K, et al. Detection of SARS-CoV-2 in human retinal biopsies of deceased COVID-19 patients. Ocul Immunol Inflamm. 2020 Jul 3; 28 (5): 721–5. doi: 10.1080/09273948.2020.1770301</mixed-citation><mixed-citation xml:lang="en">Casagrande M, Fitzek A, Puschel K, et al. Detection of SARS-CoV-2 in human retinal biopsies of deceased COVID-19 patients. Ocul Immunol Inflamm. 2020 Jul 3; 28 (5): 721–5. doi: 10.1080/09273948.2020.1770301</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Marinho P, Marcos A, Romano A, et al. Retinal findings in hospitalised patients with severe COVID-19. Lancet. 2020 May 23; 395 (10237): 1610. doi: 10.1016/S0140-6736(20)31014-X</mixed-citation><mixed-citation xml:lang="en">Marinho P, Marcos A, Romano A, et al. Retinal findings in hospitalised patients with severe COVID-19. Lancet. 2020 May 23; 395 (10237): 1610. doi: 10.1016/S0140-6736(20)31014-X</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Pereira LA, Soares LCM, Nascimento PA, et al. Retinal findings in hospitalised patients with severe COVID-19. Br J Ophthalmol. 2022 Jan; 106 (1): 102–5. doi:10.1136/bjophthalmol-2020-317576</mixed-citation><mixed-citation xml:lang="en">Pereira LA, Soares LCM, Nascimento PA, et al. Retinal findings in hospitalised patients with severe COVID-19. Br J Ophthalmol. 2022 Jan; 106 (1): 102–5. doi:10.1136/bjophthalmol-2020-317576</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Landecho MF, Yuste JR, Gándara E. COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease? J Intern Med. 2021 Jan; 289 (1): 116–20. doi: 10.1111/joim.13156</mixed-citation><mixed-citation xml:lang="en">Landecho MF, Yuste JR, Gándara E. COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease? J Intern Med. 2021 Jan; 289 (1): 116–20. doi: 10.1111/joim.13156</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Abrishami M, Emamverdian Z, Shoeibi N, et al. Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: a case-control study. Can J Ophthalmol. 2021 Feb; 56 (1): 24–30. doi: 10.1016/j.jcjo.2020.11.006</mixed-citation><mixed-citation xml:lang="en">Abrishami M, Emamverdian Z, Shoeibi N, et al. Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: a case-control study. Can J Ophthalmol. 2021 Feb; 56 (1): 24–30. doi: 10.1016/j.jcjo.2020.11.006</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Abrishami M, Tohidinezhad F, Emamverdian Z, et al. Macular thickness and volume assessed by spectral-domain optical coherence tomography in patients with coronavirus disease 2019: a case-control study. Int Ophthalmol. 2021; 41 (5): 1703–10. doi:10.21203/rs.3.rs-133611/v1</mixed-citation><mixed-citation xml:lang="en">Abrishami M, Tohidinezhad F, Emamverdian Z, et al. Macular thickness and volume assessed by spectral-domain optical coherence tomography in patients with coronavirus disease 2019: a case-control study. Int Ophthalmol. 2021; 41 (5): 1703–10. doi:10.21203/rs.3.rs-133611/v1</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Pirraglia MP, Ceccarelli G, Cerini A, et al. Retinal involvement and ocular findings in COVID-19 pneumonia patients. Sci Rep. 2020; 10 (1): 17419. https://doi.org/10.1038/s41598-020-74446-6</mixed-citation><mixed-citation xml:lang="en">Pirraglia MP, Ceccarelli G, Cerini A, et al. Retinal involvement and ocular findings in COVID-19 pneumonia patients. Sci Rep. 2020; 10 (1): 17419. https://doi.org/10.1038/s41598-020-74446-6</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Invernizzi A, Torre A, Parrulli S, et al. Retinal findings in patients with COVID-19: results from the SERPICO-19 study. EClinicalMedicine. 2020; 27: 100550. doi: 10.1016/j.eclinm.2020.100550</mixed-citation><mixed-citation xml:lang="en">Invernizzi A, Torre A, Parrulli S, et al. Retinal findings in patients with COVID-19: results from the SERPICO-19 study. EClinicalMedicine. 2020; 27: 100550. doi: 10.1016/j.eclinm.2020.100550</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Patel NS, Moon JY, Katz R, et al. Retrospective analysis of retinal imaging in COVID-19 positive patients at a tertiary eye care center. Clin Ophthalmol. 2021 Sep 3; 15: 3727–31. doi: 10.2147/OPTH.S309346</mixed-citation><mixed-citation xml:lang="en">Patel NS, Moon JY, Katz R, et al. Retrospective analysis of retinal imaging in COVID-19 positive patients at a tertiary eye care center. Clin Ophthalmol. 2021 Sep 3; 15: 3727–31. doi: 10.2147/OPTH.S309346</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Sim R, Cheung G, Ting D, et al. Retinal microvascular signs in COVID-19. Br J Ophthalmol. 2022 Sep; 106 (9): 1308–12. doi: 10.1136/bjophthalmol-2020-318236</mixed-citation><mixed-citation xml:lang="en">Sim R, Cheung G, Ting D, et al. Retinal microvascular signs in COVID-19. Br J Ophthalmol. 2022 Sep; 106 (9): 1308–12. doi: 10.1136/bjophthalmol-2020-318236</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang L, Yang Y, Gandhewar J. Bilateral corneal endothelial failure following COVID-19 pneumonia. BMJ Case Rep. 2021 Sep 20; 14 (9): e242702. doi: 10.1136/bcr-2021-242702</mixed-citation><mixed-citation xml:lang="en">Jiang L, Yang Y, Gandhewar J. Bilateral corneal endothelial failure following COVID-19 pneumonia. BMJ Case Rep. 2021 Sep 20; 14 (9): e242702. doi: 10.1136/bcr-2021-242702</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Erdem S, Karahan M, Ava S, et al. Examination of the effects of COVID-19 on corneal endothelium. Graefes Arch Clin Exp Ophthalmol. 2021 Aug; 259 (8): 2295–300. doi: 10.1007/s00417-021-05259-0</mixed-citation><mixed-citation xml:lang="en">Erdem S, Karahan M, Ava S, et al. Examination of the effects of COVID-19 on corneal endothelium. Graefes Arch Clin Exp Ophthalmol. 2021 Aug; 259 (8): 2295–300. doi: 10.1007/s00417-021-05259-0</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
