helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2025-18-4-164-168helmholtzeyeinstitute-1971Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSПрименение кросслинкинга роговицы у детей с кератоконусом. Обзор литературыCorneal crosslinking in children with keratoconus. Literature reviewhttps://orcid.org/0000-0001-9578-8635ЗайнутдиноваГ. Х.ZainutdinovaG. Kh.

Гузель Халитовна Зайнутдинова — д-р мед. наук, старший научный сотрудник отдела организации научных исследований и разработок

ул. Пушкина, д. 90, Уфа, 450008

Guzel K. Zainutdinova — Dr. of Med. Sci., senior researcher of the scientific and educational department

90 Pushkin St., Ufa, 450008

gusel.zai@yandex.ruhttps://orcid.org/0000-0002-0569-1264КазакбаеваГ. М.KazakbaevaG. M.

Гюлли Мухаррамовна Казакбаева — канд. мед. наук, заведующая отделом офтальмологической и медицинской эпидемиологии

ул. Пушкина, д. 90, Уфа, 450008

Gyulli M. Kazakbaeva — Cand. of Med. Sci., head of the department of ophthalmological and medical epidemiology

90 Pushkin St., Ufa, 450008

https://orcid.org/0009-0008-6246-0826ИнсаповаА. В.InsapovaA. V.

Анастасия Валерьевна Инсапова — научный сотрудник, отдел офтальмологической и медицинской эпидемиологии

ул. Пушкина, д. 90, Уфа, 450008

Anastasia V. Insapova — researcher, department of ophthalmological and medical epidemiology

90 Pushkin St., Ufa, 450008

https://orcid.org/0009-0003-4415-4124ТимербулатоваД. А.TimerbulatovaD. A.

Диана Артуровна Тимербулатова — научный сотрудник, отдел офтальмологической и медицинской эпидемиологии

ул. Пушкина, д. 90, Уфа, 450008

Diana A. Timerbulatova — researcher, department of ophthalmological and medical epidemiology

90 Pushkin St., Ufa, 450008

https://orcid.org/0009-0003-3958-2255БагмановР. И.BagmanovR. I.

Радмир Ильшатович Багманов — врач-офтальмолог 1-го микрохирургического отделения

ул. Пушкина, д. 90, Уфа, 450008

Radmir I. Bagmanov — ophthalmologist, 1st microsurgical department

90 Pushkin St., Ufa, 450008

Уфимский научно-исследовательский институт глазных болезней Минздрава России ФГБОУ ВО БГМУ Минздрава РоссииРоссияUfa Eye Research Institute of Bashkir State Medical UniversityRussian Federation202509012026184164168Copyright © Зайнутдинова Г.Х., Казакбаева Г.М., Инсапова А.В., Тимербулатова Д.А., Багманов Р.И., 20262026Зайнутдинова Г.Х., Казакбаева Г.М., Инсапова А.В., Тимербулатова Д.А., Багманов Р.И.Zainutdinova G.K., Kazakbaeva G.M., Insapova A.V., Timerbulatova D.A., Bagmanov R.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/1971

Представлен анализ данных литературы о результатах применения кросслинкинга (CXL) роговицы для лечения кератоконуса (КК) у пациентов детского возраста. Сообщения о результатах CXL роговицы у детей с КК достаточно многочисленны, однако в основном исследования проведены в небольших когортных группах, имеют короткий период наблюдения, мнения об эффективности разных протоколов данной процедуры разноречивые. Результаты всех исследований свидетельствует о том, что CXL останавливает или замедляет прогрессирование КК у детей. Ввиду быстрого прогрессирования КК в детском возрасте некоторые авторы предлагают применение CXL роговицы даже при отсутствии документального подтверждения признаков прогрессии. Разработка наиболее оптимального протокола CXL роговицы с высокой эффективностью и безопасностью для детей различных возрастных групп остается важной проблемой, что требует продолжения исследований.

The article presents a review of the literature data on the results of corneal crosslinking (CXL) for the treatment of keratoconus (KC) in pediatric patients. There are many reports on the results of corneal CXL in children with KC, but most studies were conducted in small cohort groups, have a short follow-up period, and there are conflicting opinions on the effectiveness of different protocols for this procedure. The use of this procedure in the treatment of pediatric KC stops or slows down its progression according to the results of all studies. Due to the rapid progression of KC in childhood, some authors suggest the use of corneal CXL even in the absence of documentary evidence of disease progression. The development of the most optimal corneal CXL protocol with high efficiency and safety for children of different age groups remains an important problem, which requires further research.

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The authors declare that there are no conflicts of interest present.