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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2026-19-1-91-98</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-2053</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Роль морфометрических и биомеханических параметров роговицы в мониторинге глаукомы</article-title><trans-title-group xml:lang="en"><trans-title>The role of morphometric and biomechanical parameters of the cornea in glaucoma monitoring</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1448-9690</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малышев</surname><given-names>A. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Malyshev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Владиславович Малышев — д-р мед. наук, профессор, заведующий кафедрой офтальмологии, ФГБОУ ВО «Майкопский государственный технологический университет»; заведующий отделением офтальмологии, ГБУЗ «Научно-исследовательский институт — Краевая клиническая больница № 1 им. профессора С.В. Очаповского»</p><p>ул. Первомайская, д. 191, Майкоп, Республика Адыгея, 385000, </p><p>ул. 1 Мая, д. 167, Краснодар, 350086</p></bio><bio xml:lang="en"><p>Aleksey V.  Malyshev — Dr. of Med. Sci., professor, head of chair of ophthalmology, Maykop State Technological University; head of the department of ophthalmology, Scientific Research Institution — S.V. Ochapovsky Regional Clinic Hospital No. 1</p><p>192, Pervomaiskaya st., Maykop, Adygea Republic, 385000, </p><p>167, May St., Krasnodar, 350086</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-3177-4342</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Апостолова</surname><given-names>A. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Apostolova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анастасия Станиславовна Апостолова — канд. мед. наук, доцент кафедры офтальмологии, ФГБОУ ВО «Майкопский государственный технологический университет»; врач-глаукоматолог, Клиника заботы о зрении «3Z»</p><p>ул. Первомайская, д. 191, Майкоп, Республика Адыгея, 385000, </p><p>ул. Красных Партизан, д. 18, Краснодар, 350047, </p><p> </p></bio><bio xml:lang="en"><p>Anastasia S. Apostolova — Cand. of Med. Sci., аssistant professor of chair of ophthalmology, Maykop State Technological University;glaucoma specialist, Vision care clinic “3Z”</p><p>192, Pervomaiskaya st., Maykop, Adygea Republic, 385000, </p><p>18, Krasnykh Partizan St., Krasnodar, 350047, </p><p> </p></bio><email xlink:type="simple">apostolovan@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергиенко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergienko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Анатольевич Сергиенко — канд. мед. наук, доцент кафедры офтальмологии, ФГБОУ ВО «Майкопский государственный технологический университет»; врач глазного отделения, ГБУЗ «Детская краевая клиническая больница» Минздрава Краснодарского края</p><p>ул. Первомайская, д. 191, Майкоп, Республика Адыгея, 385000, </p><p>пл. Победы, д. 1, Краснодар, 350007, </p><p> </p></bio><bio xml:lang="en"><p>Aleksey A. Sergienko — Cand. of Med. Sci., аssistant professor of chair of ophthalmology, Maykop State Technological University; ophthalmologist, Children’s Regional Clinical Hospital, Ministry of Health of the Krasnodar Territory</p><p>192, Pervomaiskaya st., Maykop, Adygea Republic, 385000, </p><p>1, Pobedy Square, Krasnodar, 1350007,</p><p> </p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тешев</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Teshev</surname><given-names>A. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Адам Феликсович Тешев — доцент кафедры офтальмологии, ФГБОУ ВО «Майкопский государственный технологический университет»; заведующий отделением, ГБУЗ РА «Адыгейская республиканская клиническая больница»</p><p>ул. Первомайская, д. 191, Майкоп, Республика Адыгея, 385000, </p><p>ул. Жуковского, д. 4, Майкоп, 385000</p></bio><bio xml:lang="en"><p>Adam F. Teshev — assistant professor of chair of ophthalmology, Maykop State Technological University; head of the ophthalmology department, Adygean Republican Clinical Hospital of the Republic of Adygea</p><p>192, Pervomaiskaya st., Maykop, Adygea Republic, 385000, </p><p>4, Zhukovsky St., Maikop, 385000</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карапетов</surname><given-names>Г. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Karapetov</surname><given-names>G. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гарри Юрьевич Карапетов — канд. мед. наук, доцент кафедры офтальмологии, ФГБОУ ВО «Майкопский государственный технологический университет»; врач глазного отделения, ГБУЗ «Научно-исследовательский институт — Краевая клиническая больница № 1 им. профессора С.В. Очаповского»</p><p>ул. Первомайская, д. 191, Майкоп, Республика Адыгея, 385000, </p><p>ул. 1 Мая, д. 167, Краснодар, 350086</p></bio><bio xml:lang="en"><p>Garry Yu. Karapetov — Cand. of Med. Sci., assistant professor of chair of ophthalmology, Maykop State Technological University; ophthalmologist of the ophthalmology department, Scientific Research Institution — S.V. Ochapovsky Regional Clinic Hospital No. 1</p><p>192, Pervomaiskaya st., Maykop, Adygea Republic, 385000, </p><p>167, May St., Krasnodar, 350086</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ашхамахова</surname><given-names>М. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Ashkhamakhova</surname><given-names>M. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марина Кадыровна Ашхамахова — ассистент кафедры офтальмологии, ФГБОУ ВО «Майкопский государственный технологический университет»; врач глазного отделения, ГБУЗ РА «Адыгейская республиканская клиническая больница»</p><p>ул. Первомайская, д. 191, Майкоп, Республика Адыгея, 385000, </p><p>ул. Жуковского, д. 4, Майкоп, 385000</p></bio><bio xml:lang="en"><p>Marina K. Ashkhamakhova — assistant professor of chair of ophthalmology, Maykop State Technological University; ophthalmologist of the ophthalmology department, Adygean Republican Clinical Hospital of the Republic of Adygea</p><p>192, Pervomaiskaya st., Maykop, Adygea Republic, 385000, </p><p>4, Zhukovsky St., Maikop, 385000</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хацукова</surname><given-names>Б. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Hatsukova</surname><given-names>B. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белла Нальбиевна Хацукова — ассистент кафедры офтальмологии, ФГБОУ ВО «Майкопский государственный технологический университет»; врач глазного отделения, ГБУЗ РА «Адыгейская республиканская клиническая больница»</p><p>ул. Первомайская, д. 191, Майкоп, Республика Адыгея, 385000, </p><p>ул. Жуковского, д. 4, Майкоп, 385000</p></bio><bio xml:lang="en"><p>Bella N. Hatsukova — assistant professor of chair of ophthalmology, Maykop State Technological University; ophthalmologist of the ophthalmology department, Adygean Republican Clinical Hospital of the Republic of Adygea</p><p>192, Pervomaiskaya st., Maykop, Adygea Republic, 385000, </p><p>4, Zhukovsky St., Maikop, 385000</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Майкопский государственный технологический университет»;&#13;
ГБУЗ «Научно-исследовательский институт — Краевая клиническая больница № 1 им. профессора С.В. Очаповского»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Maykop State Technological University;&#13;
Scientific Research Institution — S.V. Ochapovsky Regional Clinic Hospital No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Майкопский государственный технологический университет»;&#13;
Клиника заботы о зрении «3Z»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Maykop State Technological University;&#13;
Vision care clinic “3Z”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Майкопский государственный технологический университет»;&#13;
ГБУЗ «Детская краевая клиническая больница» Минздрава Краснодарского края</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Maykop State Technological University;&#13;
Children’s Regional Clinical Hospital, Ministry of Health of the Krasnodar Territory</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Майкопский государственный технологический университет»;&#13;
ГБУЗ РА «Адыгейская республиканская клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Maykop State Technological University;&#13;
Adygean Republican Clinical Hospital of the Republic of Adygea</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>05</day><month>04</month><year>2026</year></pub-date><volume>19</volume><issue>1</issue><fpage>91</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Малышев A.В., Апостолова A.С., Сергиенко А.А., Тешев А.Ф., Карапетов Г.Ю., Ашхамахова М.К., Хацукова Б.Н., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Малышев A.В., Апостолова A.С., Сергиенко А.А., Тешев А.Ф., Карапетов Г.Ю., Ашхамахова М.К., Хацукова Б.Н.</copyright-holder><copyright-holder xml:lang="en">Malyshev A.V., Apostolova A.S., Sergienko A.A., Teshev A.F., Karapetov G.Y., Ashkhamakhova M.K., Hatsukova B.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/2053">https://roj.igb.ru/jour/article/view/2053</self-uri><abstract><p>Цель работы — изучить роль морфометрических и биомеханических показателей роговицы в диагностике и мониторинге глаукомы.</p><sec><title>Материал и методы</title><p>Материал и методы. Обследованы 463 глаза пациентов в возрасте от 17 до 94 лет: 18 глаз молодых здоровых лиц (без глаукомы), 91 глаз без псевдоэксфолиативного синдрома (ПЭС) старшей возрастной группы, 33 глаза без глаукомы с ПЭС, 30 глаз лиц молодого возраста с близорукостью, 69 глаз с первичной открытоугольной глаукомой, 81 глаз с псевдоэксфолиативной глаукомой, 60 глаз с глаукомой низкого давления, 62 глаза с синдромом пигментной дисперсии, 19 глаз с ювенильной глаукомой. Во всех случаях глаукома была компенсирована. С помощью CorVis ST (Oculus) определяли внутриглазное давление (ВГД) с учетом биомеханических свойств фиброзной оболочки глаза (bIOP), а также биомеханические показатели: DA Ratio, Integr. Radius (IR), SP-A1, SSI.</p></sec><sec><title>Результаты</title><p>Результаты. Выявлена зависимость между центральной толщиной роговицы (ЦТР) и развитием глаукомы (r = –0,244, р = 0,000), а также уровнем ВГД, измеренным стандартной бесконтактной тонометрией (r = 0,301, р = 0,000). Установлено, что с возрастом снижается ЦТР (r = –0,205, р = 0,000) и bIOP (r = –0,111, р = 0,012) и увеличивается SSI (r = 0,516, р = 0,000). DA Ratio и IR связаны с bIOP (r = –0,647 и r = –0,652 соответственно, р = 0,000) и с ЦТР (r = –0,449 и r = –0,456 соответственно, р = 0,000). DA Ratio снижается при старении (r = 0,108, р = 0,016), IR не изменяется (р = 0,208). SP-A1 увеличивается при росте bIOP (r = 0,481, р = 0,000) и при «толстых» роговицах (r = 0,421, р = 0,000). Индекс SSI взаимосвязан с аксиальной длиной глаза и снижается при ее увеличении (r = –0,441, р = 0,000), он более высокий при «толстых» роговицах (r = 0,142, р = 0,001).</p></sec><sec><title>Заключение</title><p>Заключение. ЦТР является независимым фактором риска развития глаукомы, измененяется с возрастом и при развитии глаукомного поражения. Показатели жесткости роговицы важно оценивать в динамике для определения достижения толерантного ВГД.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: to study the role of morphometric and biomechanical parameters of the cornea in the diagnosis and monitoring of glaucoma.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A total of 463 eyes of patient aged 17 to 94 years were analyzed: 18 healthy, without glaucoma, without PEX of the older age group — 91, without glaucoma with PEX — 33, young myopic — 30, with POAG — 69, with primary open-angle pseudoexfoliation glaucoma (PXG) — 81, with normal tension glaucoma (NTG) — 60, with pigment dispersion syndrome — 62, with juvenile glaucoma (JG) — 19. In case of glaucoma, it was compensated. IOP was studied taking into account the biomechanical properties of the fibrous membrane of the eye (bIOP), DA Ratio, Integr. Radius (IR), SP-A1, SSI.</p></sec><sec><title>Results</title><p>Results. There is a relationship between the central corneal thickness (CCT) and the development of glaucoma (r = –0.244, p = 0.000), IOP level measured by standard non-contact tonometry (r = 0.301, p = 0.000). It was found a decrease of CCT (r = –0.205, p = 0.000) and bIOP (r = –0.111, p = 0.012) with age. DA Ratio and Integr. Radius are associated with bIOP (r = -0.647 and r = –0.652, respectively, p = 0.000) and with CCT (r = -0.449 and r = –0.456, respectively, p = 0.000). DA Ratio decreases with patient aging (r = 0.108, p = 0.016), but IR does not change (p = 0.208). SP-A1 increases with increasing bIOP level (r = 0.481, p = 0.000), is higher with “thick” corneas (r = 0.421, p = 0.000). The SSI index is related to the axial length of the eye and decreases as it increases (r = –0.441, p = 0.000), is higher in “thick” corneas (r = 0.142, p = 0.001), and this index also increases with age (r = 0.516, p = 0.000).</p></sec><sec><title>Conclusions</title><p>Conclusions. CCT is an independent risk factor for glaucoma development, undergoes changes with age and development of glaucomatous damage. Corneal rigidity indicators are important to evaluate dynamically to determine the achievement of tolerant IOP.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>первичная открытоугольная глаукома</kwd><kwd>глаукома низкого давления</kwd><kwd>центральная толщина роговицы</kwd><kwd>тонометрия</kwd><kwd>роговично-компенсированное давление</kwd><kwd>биомеханические свойства фиброзной оболочки глаза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>central corneal thickness</kwd><kwd>tonometry</kwd><kwd>corneal-compensated pressure</kwd><kwd>biomechanical properties of the fibrous capsule of the eye</kwd><kwd>primary open-angle glaucoma</kwd><kwd>normal tension glaucoma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Meek KM, Knupp C. Corneal structure and transparency. 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