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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2026-19-2-36-42</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-2160</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Изменения клеток эндотелия роговицы на разных стадиях кератоконуса</article-title><trans-title-group xml:lang="en"><trans-title>Corneal endothelial cells change in different stages of keratoconus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бхатти</surname><given-names>Р. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Bhatti</surname><given-names>R. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бхатти Рабиа Шариф — офтальмохирург — специалист по роговице, отделение хирургии роговицы и рефракционной хирургии.</p><p>Равалпинди, 4600</p></bio><bio xml:lang="en"><p>Rabia S. Bhatti — Ophthalmic Corneal Surgeon, Department of Cornea and Refractive Surgery.</p><p>Rawalpindi, 4600</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хан</surname><given-names>Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Khan</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хан Шама — офтальмохирург — специалист по роговице, отделение хирургии роговицы и рефракционной хирургии.</p><p>Равалпинди, 4600</p></bio><bio xml:lang="en"><p>Shama Khan — Ophthalmic Corneal Surgeon, Department of Cornea and Refractive Surgery.</p><p>Rawalpindi, 4600</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мансур</surname><given-names>Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Mansoor</surname><given-names>H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мансур Хассан — офтальмохирург – специалист по роговице, отделение хирургии роговицы и рефракционной хирургии.</p><p>Равалпинди, 4600</p></bio><bio xml:lang="en"><p>Hassan Mansoor — Ophthalmic Corneal Surgeon, Department of Cornea and Refractive Surgery.</p><p>Rawalpindi, 4600</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макбул</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Maqbool</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макбул Ауназа — детский офтальмолог, отделение детской офтальмологии.</p><p>Равалпинди, 4600</p></bio><bio xml:lang="en"><p>Aunaza Maqbool — Pediatric ophthalmologist, Department of Pediatric Ophthalmology.</p><p>Rawalpindi, 4600</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зафар</surname><given-names>Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Zafar</surname><given-names>R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зафар Рабиа — детский офтальмолог, отделение детской офтальмологии.</p><p>Равалпинди, 4600</p></bio><bio xml:lang="en"><p>Rabeeah Zafar — Pediatric ophthalmologist, Department of Pediatric Ophthalmology.</p><p>Rawalpindi, 4600</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фахим</surname><given-names>Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Faheem</surname><given-names>R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фахим Рабия — оптометрист.</p><p>Равалпинди, 4600</p></bio><bio xml:lang="en"><p>Rabia Faheem — Optometrist.</p><p>Rawalpindi, 4600</p></bio><email xlink:type="simple">rabiafahim3@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пакистанский институт офтальмологии, офтальмологическая больница «Аль-Шифа»</institution><country>Пакистан</country></aff><aff xml:lang="en"><institution>Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital</institution><country>Pakistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>18</day><month>07</month><year>2026</year></pub-date><volume>19</volume><issue>2</issue><fpage>36</fpage><lpage>42</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бхатти Р.Ш., Хан Ш., Мансур Х., Макбул А., Зафар Р., Фахим Р., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Бхатти Р.Ш., Хан Ш., Мансур Х., Макбул А., Зафар Р., Фахим Р.</copyright-holder><copyright-holder xml:lang="en">Bhatti R.S., Khan S., Mansoor H., Maqbool A., Zafar R., Faheem R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/2160">https://roj.igb.ru/jour/article/view/2160</self-uri><abstract><p>Цель работы — оценить изменения морфологии и общего количества эндотелиальных клеток у пациентов с кератоконусом (КК) на разных стадиях заболевания. Материал и методы. В поперечное исследование включены 564 глаза пациентов с КК, в том числе 57,8% мужчин и 42,2% женщин, в возрасте 19,9 ± 6,5 года. Исследование проводилось в отделении хирургии роговицы и рефракционной хирургии офтальмологической больницы Alshifa Trust в Равалпинди. Всем пациентам выполнено обследование с использованием Galilei (G4) Dual Scheimpflug Analyzer и эндотелиальная микроскопия (Tomey EM-4000). Стадии КК (1, 2, 3 и 4) были определены в соответствии с классификацией Амслера. Результаты. Выявлена статистически значимая разница в плотности эндотелиальных клеток (p &lt; 0,001) и коэффициенте вариации (p = 0,001) между разными стадиями КК. Статистически значимая разница между стадиями КК наблюдалась также по показателю площади клеточной поверхности и по морфологии клеток (p &lt; 0,001). Заключение. В глазах с КК с помощью эндотелиальной микроскопии выявлены значительные изменения в количестве и морфологии эндотелиальных клеток. На 1-й и 2-й стадиях КК эти изменения незначительны, но на 3-й и 4-й стадиях эндотелий демонстрирует значительные изменения, касающиеся полимегатизма и плеоморфизма.</p></abstract><trans-abstract xml:lang="en"><p>Purpose. To evaluate the changes in morphology and total endothelial count in patients with different stages of keratoconus (KC). Material and methods. A cross-sectional study included 564 eyes of KC patients (57.8% males and 42.2% females) aged 19.9 ± 6.5 years. Study was conducted at the Cornea and Refractive Surgery department of Alshifa trust eye hospital Rawalpindi. Galilei (G4) Dual Scheimpflug Analyzer and specular microscopy (Tomey EM-4000) were used for all eyes examination. KC eyes were classified according to Amsler classification into stage 1, 2 ,3 and 4. Results. There was statistically significant difference in endothelial cell density (p &lt; 0.001) and coefficient of variation (p = 0.001) between different stages of KC eyes. Regarding cell surface area and cell morphology, there was statistically significant difference between different stages of KC eyes (p &lt; 0.001). Conclusions. Significant changes were seen in endothelial cell count and morphology of eyes by using specular microscopy. For stages 1 and 2 KC, these changes are mild but the endothelium in stage 3 and 4 shows significant changes regarding polymegathism and pleomorphism.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кератоконус</kwd><kwd>клетки эндотелия</kwd><kwd>эндотелиальная микроскопия</kwd><kwd>полимегатизм и плеоморфизм</kwd></kwd-group><kwd-group xml:lang="en"><kwd>keratoconus</kwd><kwd>endothelial cell density</kwd><kwd>specular microscopy</kwd><kwd>polymegathism</kwd><kwd>pleomorphism</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Авторы хотели бы выразить благодарность за общую поддержку и ободрение, оказанные им в процессе подготовки этой статьи.</funding-statement><funding-statement xml:lang="en">Authors like to express their gratitude for the general support and encouragement they received during the preparation of this article.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Singh RB, Koh S, Sharma N, et al. Keratoconus. Nat Rev Dis Primers. 2024; 10: 81. doi: 10.1038/s41572-024-00565-3</mixed-citation><mixed-citation xml:lang="en">Singh RB, Koh S, Sharma N, et al. Keratoconus. Nat Rev Dis Primers. 2024; 10: 81. doi: 10.1038/s41572-024-00565-3</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998; 42 (4): 297–319. doi: 10.1016/S0039-6257(97)00119-7</mixed-citation><mixed-citation xml:lang="en">Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998; 42 (4): 297–319. doi: 10.1016/S0039-6257(97)00119-7</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hashemi H, Heydarian S, Hooshmand E, et al. The prevalence and risk factors for keratoconus: a systematic review and meta-analysis. Cornea. 2020; 39 (2): 263–70. doi: 10.1097/ICO.0000000000002150</mixed-citation><mixed-citation xml:lang="en">Hashemi H, Heydarian S, Hooshmand E, et al. The prevalence and risk factors for keratoconus: a systematic review and meta-analysis. Cornea. 2020; 39 (2): 263–70. doi: 10.1097/ICO.0000000000002150</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sriranganathan A, Chan CC, Dhillon J, Felfeli T. Global incidence and prevalence of keratoconus: a systematic review and meta-analysis. Cornea. 2025. doi: 10.1097/ICO.0000000000003973</mixed-citation><mixed-citation xml:lang="en">Sriranganathan A, Chan CC, Dhillon J, Felfeli T. Global incidence and prevalence of keratoconus: a systematic review and meta-analysis. Cornea. 2025. doi: 10.1097/ICO.0000000000003973</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gomes JA, Tan D, Rapuano CJ, et al. Global consensus on keratoconus and ectatic diseases. Cornea. 2015; 34 (4): 359–69. doi: 10.1097/ICO.0000000000000408</mixed-citation><mixed-citation xml:lang="en">Gomes JA, Tan D, Rapuano CJ, et al. Global consensus on keratoconus and ectatic diseases. Cornea. 2015; 34 (4): 359–69. doi: 10.1097/ICO.0000000000000408</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Niazi S, Gatzioufas Z, Doroodgar F, et al. Keratoconus: exploring fundamentals and future perspectives — a comprehensive systematic review. Ther Adv Ophthalmol. 2024; 16. doi: 10.1177/25158414241232258</mixed-citation><mixed-citation xml:lang="en">Niazi S, Gatzioufas Z, Doroodgar F, et al. Keratoconus: exploring fundamentals and future perspectives — a comprehensive systematic review. Ther Adv Ophthalmol. 2024; 16. doi: 10.1177/25158414241232258</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mathew JH, Goosey JD, Bergmanson JP. Quantified histopathology of the keratoconic cornea. Optom Vis Sci. 2011; 88 (8): 988–97. doi: 10.1097/OPX.0b013e31821f9f1f</mixed-citation><mixed-citation xml:lang="en">Mathew JH, Goosey JD, Bergmanson JP. Quantified histopathology of the keratoconic cornea. Optom Vis Sci. 2011; 88 (8): 988–97. doi: 10.1097/OPX.0b013e31821f9f1f</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Galvis V, Sherwin T, Tello A, et al. Keratoconus: an inflammatory disorder? Eye. 2015; 29 (7): 843–59. doi: 10.1038/eye.2015.63</mixed-citation><mixed-citation xml:lang="en">Galvis V, Sherwin T, Tello A, et al. Keratoconus: an inflammatory disorder? Eye. 2015; 29 (7): 843–59. doi: 10.1038/eye.2015.63</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bourne WM. Biology of the corneal endothelium in health and disease. Eye. 2003; 17 (8): 912–8. doi: 10.1038/sj.eye.6700559</mixed-citation><mixed-citation xml:lang="en">Bourne WM. Biology of the corneal endothelium in health and disease. Eye. 2003; 17 (8): 912–8. doi: 10.1038/sj.eye.6700559</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Laule A, Cable MK, Hoffman CE, Hanna C. Endothelial cell population changes of keratoconus patients. Am J Optom Physiol Opt. 1978; 55 (7): 447–54. doi: 10.1097/00006324-197807000-00001</mixed-citation><mixed-citation xml:lang="en">Laule A, Cable MK, Hoffman CE, Hanna C. Endothelial cell population changes of keratoconus patients. Am J Optom Physiol Opt. 1978; 55 (7): 447–54. doi: 10.1097/00006324-197807000-00001</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">El-Agha MS, El Sayed YM, Harhara RM. Corneal endothelial changes in keratoconus patients. Benha Med J. 2022; 39 (3): 1–8. doi: 10.21608/bmfj.2022.250760</mixed-citation><mixed-citation xml:lang="en">El-Agha MS, El Sayed YM, Harhara RM. Corneal endothelial changes in keratoconus patients. Benha Med J. 2022; 39 (3): 1–8. doi: 10.21608/bmfj.2022.250760</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Elmassry A, Said DG, Dua HS. Evaluation of corneal endothelial cell changes in keratoconus. Eye Contact Lens. 2021; 47 (6): 345–50. doi: 10.1097/ICL.0000000000000762</mixed-citation><mixed-citation xml:lang="en">Elmassry A, Said DG, Dua HS. Evaluation of corneal endothelial cell changes in keratoconus. Eye Contact Lens. 2021; 47 (6): 345–50. doi: 10.1097/ICL.0000000000000762</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Reinhart WJ, Musch DC, Jacobs DS, et al. Deep anterior lamellar keratoplasty as an alternative to penetrating keratoplasty: a report by the American Academy of Ophthalmology. Ophthalmology. 2011; 118 (1): 209–18. doi: 10.1016/j.ophtha.2010.11.002</mixed-citation><mixed-citation xml:lang="en">Reinhart WJ, Musch DC, Jacobs DS, et al. Deep anterior lamellar keratoplasty as an alternative to penetrating keratoplasty: a report by the American Academy of Ophthalmology. Ophthalmology. 2011; 118 (1): 209–18. doi: 10.1016/j.ophtha.2010.11.002</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ento Key. Keratoconus classification systems. Available from: https://entokey.com/keratoconus-classification-systems/ [cited 2026 May 21].</mixed-citation><mixed-citation xml:lang="en">Ento Key. Keratoconus classification systems. Available from: https://entokey.com/keratoconus-classification-systems/ [cited 2026 May 21].</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Shabayek MH, Alio JL. Intrastromal corneal ring segments for keratoconus: clinical outcomes and visual performance. J Cataract Refract Surg. 2007; 33 (7): 1308–14. doi: 10.1016/j.jcrs.2007.03.029</mixed-citation><mixed-citation xml:lang="en">Shabayek MH, Alio JL. Intrastromal corneal ring segments for keratoconus: clinical outcomes and visual performance. J Cataract Refract Surg. 2007; 33 (7): 1308–14. doi: 10.1016/j.jcrs.2007.03.029</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Borderie VM, Sandali O, Bullet J, et al. Long-term results of deep anterior lamellar keratoplasty versus penetrating keratoplasty. Ophthalmology. 2012; 119 (2): 249–55. doi: 10.1016/j.ophtha.2011.07.058</mixed-citation><mixed-citation xml:lang="en">Borderie VM, Sandali O, Bullet J, et al. Long-term results of deep anterior lamellar keratoplasty versus penetrating keratoplasty. Ophthalmology. 2012; 119 (2): 249–55. doi: 10.1016/j.ophtha.2011.07.058</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jhanji V, Sharma N, Vajpayee RB, et al. Management of keratoconus: current perspective. Br J Ophthalmol. 2011; 95 (8): 1044–50. doi: 10.1136/bjo.2010.190090</mixed-citation><mixed-citation xml:lang="en">Jhanji V, Sharma N, Vajpayee RB, et al. Management of keratoconus: current perspective. Br J Ophthalmol. 2011; 95 (8): 1044–50. doi: 10.1136/bjo.2010.190090</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Galvis V, Sherwin T, Tello A, et al. Keratoconus: an inflammatory disorder? Eye (Lond). 2015; 29: 843–59. doi: 10.1038/eye.2015.63</mixed-citation><mixed-citation xml:lang="en">Galvis V, Sherwin T, Tello A, et al. Keratoconus: an inflammatory disorder? Eye (Lond). 2015; 29: 843–59. doi: 10.1038/eye.2015.63</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Niederer RL, Perumal D, Sherwin T, et al. Keratoconus and endothelial morphology. Cornea. 2007; 26 (5): 590–6. doi: 10.1097/ICO.0b013e31803bbbdc</mixed-citation><mixed-citation xml:lang="en">Niederer RL, Perumal D, Sherwin T, et al. Keratoconus and endothelial morphology. Cornea. 2007; 26 (5): 590–6. doi: 10.1097/ICO.0b013e31803bbbdc</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hollingsworth JG, Bonshek RE, Efron N, et al. Morphology of corneal endothelium in keratoconus. Eye. 2005; 19: 1162–6. doi: 10.1038/sj.eye.6701732</mixed-citation><mixed-citation xml:lang="en">Hollingsworth JG, Bonshek RE, Efron N, et al. Morphology of corneal endothelium in keratoconus. Eye. 2005; 19: 1162–6. doi: 10.1038/sj.eye.6701732</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Elmassry A, Said DG, Dua HS, et al. Corneal endothelial cell changes in keratoconus. Eye Contact Lens. 2021; 47 (6): 345–50. doi: 10.1097/ICL.0000000000000762</mixed-citation><mixed-citation xml:lang="en">Elmassry A, Said DG, Dua HS, et al. Corneal endothelial cell changes in keratoconus. Eye Contact Lens. 2021; 47 (6): 345–50. doi: 10.1097/ICL.0000000000000762</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">U akhan , zkan M, Kanpolat A, et al. Corneal endothelial changes in keratoconus. Cornea. 2006; 25 (6): 708–13. doi: 10.1097/01.ico.0000227880.64302.8d</mixed-citation><mixed-citation xml:lang="en">U akhan , zkan M, Kanpolat A, et al. Corneal endothelial changes in keratoconus. Cornea. 2006; 25 (6): 708–13. doi: 10.1097/01.ico.0000227880.64302.8d</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Matsuda M, Suda T, Manabe R, et al. Corneal endothelial changes in keratoconus. Am J Ophthalmol. 1982; 93 (3): 342–9. doi: 10.1016/0002-9394(82)90327-6</mixed-citation><mixed-citation xml:lang="en">Matsuda M, Suda T, Manabe R, et al. Corneal endothelial changes in keratoconus. Am J Ophthalmol. 1982; 93 (3): 342–9. doi: 10.1016/0002-9394(82)90327-6</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Laing RA, Sandstrom MM, Berrospi AR, et al. Morphological changes in keratoconus endothelium. Arch Ophthalmol. 1979; 97 (10): 1865–7. doi: 10.1001/archopht.1979.01020020687011</mixed-citation><mixed-citation xml:lang="en">Laing RA, Sandstrom MM, Berrospi AR, et al. Morphological changes in keratoconus endothelium. Arch Ophthalmol. 1979; 97 (10): 1865–7. doi: 10.1001/archopht.1979.01020020687011</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
