helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2026-19-3-157-161helmholtzeyeinstitute-2241Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSАномалия Петерса: клиника, диагностика, дифференциальный диагноз, лечение. Обзор литературыPeters’ Anomaly: clinical picture, diagnosis, differential diagnosis, treatment. Literature reviewhttps://orcid.org/0000-0002-4458-4605ПлесковаА. В.PleskovaA. V.

Алла Вячеславовна Плескова — д-р мед. наук, старший научный сотрудник отдела патологии глаз у детей.

Ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Alla V. Pleskova — Dr. of Med. Sci., senior researcher, department of children’s eye pathology.

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

https://orcid.org/0000-0002-3250-4065ГетадарянВ. Р.GetadaryanV. R.

Востан Рафаелович Гетадарян — канд. мед. наук, научный сотрудник отдела патологии глаз у детей.

Ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Vostan R. Getadaryan — Cand. of Med. Sci., researcher, department of children’s eye pathology.

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

vostan11@gmail.comФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииРоссияHelmholtz National Medical Research Center of Eye DiseasesRussian Federation202628092026193157161Copyright © Плескова А.В., Гетадарян В.Р., 20262026Плескова А.В., Гетадарян В.Р.Pleskova A.V., Getadaryan V.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/2241

Представлен анализ литературы, посвященной этиологии, патогенезу, гистологии и клинической картине аномалии Петерса. На основе этих данных и собственного опыта авторы описывают опорные критерии дифференциального диагноза и лечебную тактику, дают прогноз и рекомендации по ведению пациентов с этой тяжелой врожденной аномалией.

This article presents an analysis of the literature on the etiology, pathogenesis, histology, and clinical picture of Peters’ anomaly. Based on this data and their own experience, the authors describe the key differential diagnosis criteria and treatment strategies, provide a prognosis and recommendations for the management of patients with this severe congenital anomaly.

врожденное помутнение роговицысквозная кератопластика у детейаномалия Петерсаиридокорнеальные сращенияcongenital corneal opacitypenetrating keratoplasty in childrenPeters anomalyiridocorneal adhesionsникто из авторов не имеет финансовой заинтересованности в представленных материалах или методахno author has a financial or property interest in any material or method mentionedReferencesSalik I, Gupta A, Tara A, Zaidman G, Barst S. Peters anomaly: A 5-year experience. Paediatr Anaesth. 2020 May; 30 (5): 577–83. doi: 10.1111/pan.13843Salik I, Gupta A, Tara A, Zaidman G, Barst S. Peters anomaly: A 5-year experience. Paediatr Anaesth. 2020 May; 30 (5): 577–83. doi: 10.1111/pan.13843Alkatan HM, Al Dhaheri H, Al Harby M. Terminology of Peters’ anomaly variants: Summary of histopathological findings in 6 corneas and detailed clinicopathological correlation in 2 cases. Saudi J Ophthalmol. 2019 Jul-Sep; 33 (3): 277–82. doi: 10.1016/j.sjopt.2018.02.015Alkatan HM, Al Dhaheri H, Al Harby M. Terminology of Peters’ anomaly variants: Summary of histopathological findings in 6 corneas and detailed clinicopathological correlation in 2 cases. Saudi J Ophthalmol. 2019 Jul-Sep; 33 (3): 277–82. doi: 10.1016/j.sjopt.2018.02.015Williams AL, Bohnsack BL. Neural crest derivatives in ocular development: discerning the eye of the storm. Birth Defects Res C Embryo Today. 2015 Jun; 105 (2): 87–95. doi: 10.1002/bdrc.21095Williams AL, Bohnsack BL. Neural crest derivatives in ocular development: discerning the eye of the storm. Birth Defects Res C Embryo Today. 2015 Jun; 105 (2): 87–95. doi: 10.1002/bdrc.21095Traboulsi EI, Maumenee IH. Peters’ anomaly and associated congenital malformations. Arch Ophthalmol. 1992 Dec; 110 (12): 1739–42. doi: 10.1001/archopht.1992.01080240079035Traboulsi EI, Maumenee IH. Peters’ anomaly and associated congenital malformations. Arch Ophthalmol. 1992 Dec; 110 (12): 1739–42. doi: 10.1001/archopht.1992.01080240079035Samara A, Eldaya RW. Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review. Radiol Case Rep. 2020 Apr 30; 15 (7): 863–6. doi: 10.1016/j.radcr.2020.04.011Samara A, Eldaya RW. Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review. Radiol Case Rep. 2020 Apr 30; 15 (7): 863–6. doi: 10.1016/j.radcr.2020.04.011Zaidman GW, Flanagan JK, Furey CC. Long-term visual prognosis in children after corneal transplant surgery for Peters anomaly type I. Am J Ophthalmol. 2007 Jul; 144 (1): 104–8. doi: 10.1016/j.ajo.2007.03.058Zaidman GW, Flanagan JK, Furey CC. Long-term visual prognosis in children after corneal transplant surgery for Peters anomaly type I. Am J Ophthalmol. 2007 Jul; 144 (1): 104–8. doi: 10.1016/j.ajo.2007.03.058Yang LL, Lambert SR, Lynn MJ, Stulting RD. Surgical management of glaucoma in infants and children with Peters’ anomaly: long-term structural and functional outcome. Ophthalmology. 2004 Jan; 111 (1): 112–7. doi: 10.1016/j.ophtha.2003.02.002Yang LL, Lambert SR, Lynn MJ, Stulting RD. Surgical management of glaucoma in infants and children with Peters’ anomaly: long-term structural and functional outcome. Ophthalmology. 2004 Jan; 111 (1): 112–7. doi: 10.1016/j.ophtha.2003.02.002Miao S, Lin Q, Liu Y, et al. Clinicopathologic features and treatment characteristics of congenital corneal opacity infants and children aged 3 years or less: A retrospective single institution analysis. Med Princ Pract. 2020; 29 (1): 18–24. doi: 10.1159/000501763Miao S, Lin Q, Liu Y, et al. Clinicopathologic features and treatment characteristics of congenital corneal opacity infants and children aged 3 years or less: A retrospective single institution analysis. Med Princ Pract. 2020; 29 (1): 18–24. doi: 10.1159/000501763Reis LM, Semina EV. Genetics of anterior segment dysgenesis disorders. Curr Opin Ophthalmol. 2011 Sep; 22 (5): 314–24. doi: 10.1097/ICU.0b013e328349412bReis LM, Semina EV. Genetics of anterior segment dysgenesis disorders. Curr Opin Ophthalmol. 2011 Sep; 22 (5): 314–24. doi: 10.1097/ICU.0b013e328349412bChesneau B, Aubert-Mucca M, Fremont F, et al. First evidence of SOX2 mutations in Peters’ anomaly: Lessons from molecular screening of 95 patients. Clin Genet. 2022 May; 101 (5–6): 494–506. doi: 10.1111/cge.14123Chesneau B, Aubert-Mucca M, Fremont F, et al. First evidence of SOX2 mutations in Peters’ anomaly: Lessons from molecular screening of 95 patients. Clin Genet. 2022 May; 101 (5–6): 494–506. doi: 10.1111/cge.14123Honkanen RA, Nishimura DY, Swiderski RE, et al. A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene. Am J Ophthalmol. 2003 Mar; 135 (3): 368–75. doi: 10.1016/s0002-9394(02)02061-5Honkanen RA, Nishimura DY, Swiderski RE, et al. A family with AxenfeldRieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene. Am J Ophthalmol. 2003 Mar; 135 (3): 368–75. doi: 10.1016/s0002-9394(02)02061-5Reis LM, Tyler RC, Volkmann Kloss BA, et al. PITX2 and FOXC1 spectrum of mutations in ocular syndromes. Eur J Hum Genet. 2012 Dec; 20 (12): 1224–33. doi: 10.1038/ejhg.2012.80Reis LM, Tyler RC, Volkmann Kloss BA, et al. PITX2 and FOXC1 spectrum of mutations in ocular syndromes. Eur J Hum Genet. 2012 Dec; 20 (12): 1224–33. doi: 10.1038/ejhg.2012.80Плескова А.В., Мазанова Е.В., Катаргина Л.А. Аномалия Петерса: клиника, диагностика и результаты хирургического лечения. Офтальмохирургия. 2019; 2: 44–9.Pleskova A.V., Mazanova E.V., Katargina L.A. Peters’ anomaly: clinical features, diagnostics, and surgical treatment results. Fyodorov journal of ophthalmic surgery. 2019; 2: 44–9 (In Russ.).Плескова А.В., Панова А.Ю. Клинические особенности и результаты хирургического лечения врожденных помутнений роговицы у младенцев и детей младше 3 лет. Российская педиатрическая офтальмология. 2023; 18 (4): 185–90 https://ruspoj.com/1993-1859/article/view/569148Pleskova A.V., Panova A.Yu. Clinical features and results of surgical treatment of congenital corneal opacities in infants and children under 3 years of age. Russian pediatric ophthalmology. 2023; 18 (4): 185–90 (In Russ.). https://ruspoj.com/1993-1859/article/view/569148Плескова А.В., Мазанова Е.В., Сорокин А.А. Актуальные вопросы дифференциальной диагностики и тактика лечения врожденных помутнений роговицы у детей. Офтальмохирургия. 2021; 1: 73–82.Pleskova A.V., Mazanova E.V., Sorokin A.A. Current issues of differential diagnostics and treatment tactics for congenital corneal opacities in children. Fyodorov journal of ophthalmic surgery. 2021; 1: 73–82 (In Russ.).Плескова А.В., Гетадарян В.Р., Панова А.Ю. Сравнительный анализ результатов хирургического лечения при аномалии Петерса и склерокорнеа у детей младшего возраста. Российский офтальмологический журнал. 2025; 18 (2): 90–4. https://doi.org/10.21516/2072-0076-2025-18-2-90-94Pleskova A.V., Getadaryan V.R., Panova A.Yu. Comparative analysis of the results of surgical treatment for Peters anomaly and sclerocornea in young children. Russian ophthalmological journal. 2025; 18 (2): 90–4 (In Russ.). https://doi.org/10.21516/2072-0076-2025-18-2-90-94Yang LL, Lambert SR, Lynn MJ, Stulting RD. Long-term results of corneal graft survival in infants and children with peters anomaly. Ophthalmology. 1999 Apr; 106 (4): 833–48. doi: 10.1016/S0161-6420(99)90175-6Yang LL, Lambert SR, Lynn MJ, Stulting RD. Long-term results of corneal graft survival in infants and children with peters anomaly. Ophthalmology. 1999 Apr; 106 (4): 833–48. doi: 10.1016/S0161-6420(99)90175-6Nischal KK. A new approach to the classification of neonatal corneal opacities. Curr Opin Ophthalmol. 2012 Sep; 23 (5): 344–54. doi: 10.1097/ICU.0b013e328356893dNischal KK. A new approach to the classification of neonatal corneal opacities. Curr Opin Ophthalmol. 2012 Sep; 23 (5): 344–54. doi: 10.1097/ICU.0b013e328356893dMyles WM, Flanders ME, Chitayat D, Brownstein S. Peters’ anomaly: a clinicopathologic study. J Pediatr Ophthalmol Strabismus. 1992 Nov-Dec; 29 (6): 374–81. doi: 10.3928/0191-3913-19921101-10Myles WM, Flanders ME, Chitayat D, Brownstein S. Peters’ anomaly: a clinicopathologic study. J Pediatr Ophthalmol Strabismus. 1992 Nov-Dec; 29 (6): 374–81. doi: 10.3928/0191-3913-19921101-10Hong J, Yang Y, Cursiefen C, et al. Optimising keratoplasty for Peters’ anomaly in infants using spectral-domain optical coherence tomography. Br J Ophthalmol. 2017 Jun; 101 (6): 820–7. doi: 10.1136/bjophthalmol-2016-308658Hong J, Yang Y, Cursiefen C, et al. Optimising keratoplasty for Peters’ anomaly in infants using spectral-domain optical coherence tomography. Br J Ophthalmol. 2017 Jun; 101 (6): 820–7. doi: 10.1136/bjophthalmol-2016-308658Scorcia V, Pietropaolo R, Carnevali A, et al. Results of Descemet stripping automated endothelial keratoplasty for the treatment of late corneal decompensation secondary to obstetrical forceps trauma. Cornea. 2016 Mar; 35 (3): 305–7. doi: 10.1097/ICO.0000000000000715Scorcia V, Pietropaolo R, Carnevali A, et al. Results of Descemet stripping automated endothelial keratoplasty for the treatment of late corneal decompensation secondary to obstetrical forceps trauma. Cornea. 2016 Mar; 35 (3): 305–7. doi: 10.1097/ICO.0000000000000715Tomatsu S, Pitz S, Hampel U. Ophthalmological findings in mucopolysaccharidoses. J Clin Med. 2019 Sep 14; 8 (9): 1467. doi: 10.3390/jcm8091467Tomatsu S, Pitz S, Hampel U. Ophthalmological findings in mucopolysaccharidoses. J Clin Med. 2019 Sep 14; 8 (9): 1467. doi: 10.3390/jcm8091467Smith JA, Chan CC, Goldin E, Schiffmann R. Noninvasive diagnosis and ophthalmic features of mucolipidosis type IV. Ophthalmology. 2002 Mar; 109 (3): 588–94. doi: 10.1016/s0161-6420(01)00968-xSmith JA, Chan CC, Goldin E, Schiffmann R. Noninvasive diagnosis and ophthalmic features of mucolipidosis type IV. Ophthalmology. 2002 Mar; 109 (3): 588–94. doi: 10.1016/s0161-6420(01)00968-xWeiss JS, Møller HU, Aldave AJ, et al. IC3D classification of corneal dystrophies--edition 2. Cornea. 2015 Feb; 34 (2): 117–59. doi: 10.1097/ICO.0000000000000307. Erratum in: Cornea. 2015 Oct; 34 (10): e32. Erratum in: Cornea. 2022 Dec 01; 41 (12): e23. doi: 10.1097/ICO.0000000000003175Weiss JS, Møller HU, Aldave AJ, et al. IC3D classification of corneal dystrophies--edition 2. Cornea. 2015 Feb; 34 (2): 117–59. doi: 10.1097/ICO.0000000000000307. Erratum in: Cornea. 2015 Oct; 34 (10): e32. Erratum in: Cornea. 2022 Dec 01; 41 (12): e23. doi: 10.1097/ICO.0000000000003175Pirouzian A. Management of pediatric corneal limbal dermoids. Clin Ophthalmol. 2013; 7: 607–14. doi: 10.2147/OPTH.S38663Pirouzian A. Management of pediatric corneal limbal dermoids. Clin Ophthalmol. 2013; 7: 607–14. doi: 10.2147/OPTH.S38663Elhusseiny AM, Saeed HN. Posterior polymorphous corneal dystrophy in a pediatric population. Cornea. 2022 Jun 1; 41 (6): 734–9. doi: 10.1097/ICO.0000000000002847Elhusseiny AM, Saeed HN. Posterior polymorphous corneal dystrophy in a pediatric population. Cornea. 2022 Jun 1; 41 (6): 734–9. doi: 10.1097/ICO.0000000000002847Patel HY, Ormonde S, Brookes NH, Moffatt LS, McGhee CN. The indications and outcome of paediatric corneal transplantation in New Zealand: 1991–2003. Br J Ophthalmol. 2005 Apr; 89 (4): 404–8. doi: 10.1136/bjo.2004.053116Patel HY, Ormonde S, Brookes NH, Moffatt LS, McGhee CN. The indications and outcome of paediatric corneal transplantation in New Zealand: 1991–2003. Br J Ophthalmol. 2005 Apr; 89 (4): 404–8. doi: 10.1136/bjo.2004.053116Donoso Rojas R, Jara Urrutia G, López Garin JP. Long-term experience and visual acuity outcomes in patients with Peters Anomaly. J Pediatr Ophthalmol Strabismus. 2021 Sep-Oct; 58 (5): 304–10. doi: 10.3928/01913913-20210412-01Donoso Rojas R, Jara Urrutia G, López Garin JP. Long-term experience and visual acuity outcomes in patients with Peters Anomaly. J Pediatr Ophthalmol Strabismus. 2021 Sep-Oct; 58 (5): 304–10. doi: 10.3928/01913913-20210412-01Rao KV, Fernandes M, Gangopadhyay N, et al. Outcome of penetrating keratoplasty for Peters anomaly. Cornea. 2008 Aug; 27 (7): 749–53. doi: 10.1097/ICO.0b013e31816fe9a7Rao KV, Fernandes M, Gangopadhyay N, et al. Outcome of penetrating keratoplasty for Peters anomaly. Cornea. 2008 Aug; 27 (7): 749–53. doi: 10.1097/ICO.0b013e31816fe9a7Hashemi H, Asghari H, Amanzadeh K, et al. Descemet stripping automated endothelial keratoplasty performed by cornea fellows. Cornea. 2012; 31 (9): 974–7. doi: 10.1097/ICO.0b013e318247eaedHashemi H, Asghari H, Amanzadeh K, et al. Descemet stripping automated endothelial keratoplasty performed by cornea fellows. Cornea. 2012; 31 (9): 974–7. doi: 10.1097/ICO.0b013e318247eaedSoh YQ, Mehta JS. Selective Endothelial removal for Peters Anomaly. Cornea. 2018 Mar; 37 (3): 382–5. doi: 10.1097/ICO.0000000000001472Soh YQ, Mehta JS. Selective Endothelial removal for Peters Anomaly. Cornea. 2018 Mar; 37 (3): 382–5. doi: 10.1097/ICO.0000000000001472Choe S, Yoon CH, Kim MK, et al. Spontaneous regression of congenital corneal opacity. Graefes Arch Clin Exp Ophthalmol. 2020 Feb; 258 (2): 359–66. doi: 10.1007/s00417-019-04526-5Choe S, Yoon CH, Kim MK, et al. Spontaneous regression of congenital corneal opacity. Graefes Arch Clin Exp Ophthalmol. 2020 Feb; 258 (2): 359–66. doi: 10.1007/s00417-019-04526-5Ramappa M, Chaurasia S, Mohamed A, et al. Selective endothelialectomy in Peter’s Anomaly: A novel surgical technique and its clinical outcomes in children. Cornea. 2022 Dec 1; 41 (12): 1477–86. doi: 10.1097/ICO.0000000000003134Ramappa M, Chaurasia S, Mohamed A, et al. Selective endothelialectomy in Peter’s Anomaly: A novel surgical technique and its clinical outcomes in children. Cornea. 2022 Dec 1; 41 (12): 1477–86. doi: 10.1097/ICO.0000000000003134Yang LL, Lambert SR, Lynn MJ, Stulting RD. Surgical management of glaucoma in infants and children with Peters’ anomaly: long-term structural and functional outcome. Ophthalmology. 2004 Jan; 111 (1): 112–7. doi: 10.1016/j.ophtha.2003.02.002Yang LL, Lambert SR, Lynn MJ, Stulting RD. Surgical management of glaucoma in infants and children with Peters’ anomaly: long-term structural and functional outcome. Ophthalmology. 2004 Jan; 111 (1): 112–7. doi: 10.1016/j.ophtha.2003.02.002Najjar DM, Christiansen SP, Bothun ED, Summers CG. Strabismus and amblyopia in bilateral Peter’s anomaly. J AAPOS. 2006 Jun; 10 (3): 193–7. doi: 10.1016/j.jaapos.2006.01.006Najjar DM, Christiansen SP, Bothun ED, Summers CG. Strabismus and amblyopia in bilateral Peter’s anomaly. J AAPOS. 2006 Jun; 10 (3): 193–7. doi: 10.1016/j.jaapos.2006.01.006Elbaz U, Strungaru H, Mireskandari K, Stephens D, Ali A. Long-term visual outcomes and clinical course of patients with Peters Anomaly. Cornea. 2021 Jul 1; 40 (7): 822–30. doi: 10.1097/ICO.0000000000002577Elbaz U, Strungaru H, Mireskandari K, Stephens D, Ali A. Long-term visual outcomes and clinical course of patients with Peters Anomaly. Cornea. 2021 Jul 1; 40 (7): 822–30. doi: 10.1097/ICO.0000000000002577Dolezal KA, Besirli CG, Mian SI, et al. Glaucoma and cornea surgery outcomes in Peter’s Anomaly. Am J Ophthalmol. 2019 Dec; 208: 367–75. doi: 10.1016/j.ajo.2019.08.012Dolezal KA, Besirli CG, Mian SI, et al. Glaucoma and cornea surgery outcomes in Peter’s Anomaly. Am J Ophthalmol. 2019 Dec; 208: 367–75. doi: 10.1016/j.ajo.2019.08.012

The authors declare that there are no conflicts of interest present.