helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2019-12-1-103-111helmholtzeyeinstitute-231Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSЛимбальная недостаточность: этиология, патогенез, принципы и перспективы хирургического леченияLimbal stem cell deficiency: etiology, pathogenesis, priniciples and prospects of surgical treatmentДубовиковА. С.DubovikovA. S.

 клинический ординатор

194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

 

resident

6, Akademika Lebedeva St., St. Petersburg, 194044, Russia

dubovikovanatolyi@gmail.comГаврилюкИ. О.GavrilyukI. O.

врач-офтальмолог

 194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

ophthalmologist

6, Akademika Lebedeva St., St. Petersburg, 194044, Russia

КуликовА. Н.KulikovA. N.

д-р мед. наук, начальник кафедры офтальмологии

194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

 

Dr. Med. Sci., head of the chair of ophthalmology

6, Akademika Lebedeva St., St. Petersburg, 194044, Russia

ЧурашовС. В.ChurashovS. V.

д-р мед. наук, доцент, профессор кафедры

194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

Dr. Med. Sci., assistant professor of the chair of ophthalmology

6, Akademika Lebedeva St., St. Petersburg, 194044, Russia

ЧернышВ. Ф.ChernyshV. F.

канд. мед. наук, доцент, доцент кафедры

194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

Cand. Med. Sci., assistant professor of the chair of ophthalmology

6, Akademika Lebedeva St., St. Petersburg, 194044, Russia

БезушкоА. В.BezushkoA. V.

врач-офтальмолог

194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

ophthalmologist

6, Akademika Lebedeva St., St. Petersburg, 194044, Russia

ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Министерства обороныРоссияS.M. Kirov Military Medical AcademyRussian Federation201915032019121103111Copyright © Дубовиков А.С., Гаврилюк И.О., Куликов А.Н., Чурашов С.В., Черныш В.Ф., Безушко А.В., 20192019Дубовиков А.С., Гаврилюк И.О., Куликов А.Н., Чурашов С.В., Черныш В.Ф., Безушко А.В.Dubovikov A.S., Gavrilyuk I.O., Kulikov A.N., Churashov S.V., Chernysh V.F., Bezushko A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/231

Обзор посвящен современному представлению об этиологии и патогенезе лимбальной недостаточности, рассмотрена история развития тканевой и клеточной трансплантации лимбальных эпителиальных стволовых клеток, а также обсуждены некоторые перспективные направления лечения пациентов с лимбальной недостаточностью.

The review is focused on the modern view of the etiology and pathogenesis of limbal stem cells deficiency. The history of development of tissue and ex-vivo transplantation of limbal epithelial stem cells is presented. Certain promising directions of the treatment of patients with limbal stem cells deficiency are presented.

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The authors declare that there are no conflicts of interest present.