helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2016-9-2-55-60helmholtzeyeinstitute-27Research ArticleКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯCLINICAL STUDIESЛокальные и системные уровни эритропоэтина при осложненной пролиферативной диабетической ретинопатииLocal and systemic erythropoietin levels in complicated proliferative diabetic retinopathyНероевВ. В.NeroevV. V.noemail@neicon.ruЗайцеваО. В.ZaitsevaO. V.noemail@neicon.ruКурчаеваЗ. В.KurchaevaZ. V.noemail@neicon.ruСлеповаО. С.SlepovaO. S.noemail@neicon.ruФГБУ «Московский НИИ глазных болезней им. Гельмгольца» Минздрава РоссииРоссияHelmholtz Research Institute of Eye Diseases, Moscow, RussiaRussian Federation201603102018925560Copyright © Нероев В.В., Зайцева О.В., Курчаева З.В., Слепова О.С., 20182018Нероев В.В., Зайцева О.В., Курчаева З.В., Слепова О.С.Neroev V.V., Zaitseva O.V., Kurchaeva Z.V., Slepova O.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/27

Изучено содержание эритропоэтина (ЭПО) в биологических жидкостях 43 больных сахарным диабетом 1-го и 2-го типа при различных клинических вариантах осложненной пролиферативной диабетической ретинопатии (ПДР), в том числе стабильном течении ПДР, а также 12 пациентов с регматогенной отслойкой сетчатки и у 15 здоровых лиц. Корреляции уровней ЭПО с особенностями клинической картины осложненной ПДР отмечены только на локальном уровне (в стекловидном теле). Максимальные интраокулярные уровни ЭПО ассоциировались с тяжелой клинической картиной заболевания, обильной васкуляризацией фиброглиальной ткани и развитием интраоперационных геморрагических осложнений, что подтверждает концепцию об активном участии локально секретируемого ЭПО в глазном неоангиогенезе, в том числе при прогрессировании ПДР // Российский офтальмологический журнал, 2016; 2: 55-60.

The levels of erythropoietin (EPO) in biological fluids were studied on 43 patients with diabetes mellitus type I and II who suffered from a variety of clinical manifestations of heavy proliferative diabetic retinopathy (PDR) which incuded stable PDR, 12 patients with rhegmatogenous retinal detachment and 15 healthy individuals The correlation of EPO levels with the clinical features of heavy PDR was noted only at the local level (intravitreally). The highest intraocular levels of EPO were associated with severe features of the disease, abundant vascularizarion of fibroglial tissue, and intraoperative hemorrhagic complications, which corroborates the theory of active participation of locally secreted EPO in ocular neoangiogenesis, including the progression of PDR // Russian Ophthalmological Journal, 2016; 2: 55-60. doi: 10.21516/2072-0076-2016-9-2-55-60 .

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The authors declare that there are no conflicts of interest present.