helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2019-12-3-95-100helmholtzeyeinstitute-306Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSПерсонализированная медицина в решении проблемы глаукомыPersonalized medicine in glaucoma managementЖуравлеваА. Н.ZhuravlevaA. N.

канд. мед. наук, научный сотрудник отдела глаукомы 

105062, г. Москва, ул. Садовая-Черногрязская, д. 14/19

 Cand. Med. Sci., researcher, glaucoma department 

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

zh.eye@mail.ruКиселеваО. А.KiselevaO. A.

д-р мед. наук, начальник отдела глаукомы

105062, г. Москва, ул. Садовая-Черногрязская, д. 14/19

Dr. Med. Sci., head, glaucoma department 

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

КирилловаМ. О.KirillovaM. O.

аспирант отдела глаукомы

105062, г. Москва, ул. Садовая-Черногрязская, д. 14/19

Ph.D. student, glaucoma department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

ФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииРоссияHelmholtz National Medical Research Center of Eye DiseasesRussian Federation20193108201912395100Copyright © Журавлева А.Н., Киселева О.А., Кириллова М.О., 20192019Журавлева А.Н., Киселева О.А., Кириллова М.О.Zhuravleva A.N., Kiseleva O.A., Kirillova M.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/306

В обзоре рассмотрена проблема первичной глаукомы как социально значимого многофакторного заболевания. Обозначены основные причины, препятствующие своевременной диагностике и лечению больных глаукомой: «размытость границ», условность нормативов, недостаточно индивидуальный подход к лечению. Выделены основные факторы риска развития глаукомы, особое внимание уделено наследственной предрасположенности, отмечена роль «медицины будущего» в решении проблемы глаукомы. Описаны четыре основополагающих принципа: персонализация, предикция, превентивность и партисипативность (4П-медицина). Показано, что расширение научных представлений о ключевых факторах риска развития и прогрессирования глаукомы вместе с современным персонализированным и персонифицированным подходом позволят в дальнейшем разрабатывать точные индивидуальные стратегии профилактики и лечения данного заболевания.

The review addresses the management of primary glaucoma as a socially significant multifactorial disease. The main reasons that impede the timely diagnosis and treatment of patients with glaucoma are indicated: blurring of boundaries, conventionality of standards, and lack of individualized approach to treatment. The main risk factors for the development of glaucoma are highlighted, with special attention to hereditary predisposition and the role of “medicine of the future” in managing glaucoma. Four fundamental principles are described: personalization, prediction, prevention and participative attitude (P4 medicine). Advanced scientific understanding of the key risk factors for the development and progression of glaucoma, together with a modern personalized and personified approach will further develop precise individual strategies for the prevention and treatment of the disease.

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The authors declare that there are no conflicts of interest present.