helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2016-9-3-34-41helmholtzeyeinstitute-40Research ArticleКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯCLINICAL STUDIESСНИЖЕНИЕ ПЕРИПАПИЛЛЯРНОГО КРОВОТОКА КАК ФАКТОР РАЗВИТИЯ И ПРОГРЕССИРОВАНИЯ ПЕРВИЧНОЙ ОТКРЫТОУГОЛЬНОЙ ГЛАУКОМЫA reduced peripapillary blood flow as a factor of primary open angle glaucoma development and progressionКурышеваН. И.KuryshevaN. I.noemail@neicon.ruМасловаЕ. В.MaslovaE. V.noemail@neicon.ruТрубилинаА. В.TrubilinaA. V.noemail@neicon.ruЦентр офтальмологии ФМБА РоссииРоссияOphthalmological Center of the Federal Medical and Biological AgencyRussian Federation201603102018933441Copyright © Курышева Н.И., Маслова Е.В., Трубилина А.В., 20182018Курышева Н.И., Маслова Е.В., Трубилина А.В.Kurysheva N.I., Maslova E.V., Trubilina A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/40

Цель работы - оценить состояние гемоперфузии перипапиллярной зоны сетчатки у больных первичной открытоугольной глаукомой (ПОУГ) с использованием оптической когерентной томографии с функцией декорреляционной амплитудной ангиографии (ОКТ-А). Исследование проведено на 65 глазах больных ПОУГ разных стадий. Группу контроля составили 22 глаза здоровых обследуемых аналогичного возраста без офтальмопатологии. Методом спектральной оптической когерентной томографии (SD-ОСТ) с функцией AngioVue ОКТ-А определяли усреднённое значение величины декорреляции амплитуды (Peripapillary Flow Index), плотность микрососудистой сети (Peripapillary Vessel Density), параметры комплекса ганглиозных клеток (GCC), в том числе объем фокальных (FLV) и глобальных (GLV) потерь, толщина слоя нервных волокон сетчатки (RNFL). Результаты показали, что снижение кровотока в перипапиллярной сетчатке, выявляемое методом ОКТ-А, опережает не только функциональные, но и структурные потери, определяемые методами ОКТ и периметрии // Российский офтальмологический журнал, 2016; 3: 34-41.

To assess the blood supply to the peripapillary area in patients with primary open-angle glaucoma (POAG) using optical coherence tomography with the function of amplitude decorrelation angiography (OCT-A). Material and Methods. 65 eyes of POAG patients (the main group) and 22 eyes of age-matched healthy subjects (the control group) were examined. Spectral OCT (SD-OCT) technique with AngioVue OCT function was used to measure the average value of amplitude decorrelation (Peripapillary Flow Index), peripapillary vessel density, the parameters of the ganglion cell complex (GCC), including the focal loss volume (FLV) and the global loss volume (GLV), and the retinal nerve fiber layer (RNFL). Results. We revealed that blood flow reduction in the peripapillary retina, detected by OCT-A, precedes not only the functional but also the structural loss, determined by OCT and SAP. Conclusions. The new noninvasive technique for the examination of retinal blood flow, OCT-A, determines the reduction of hemoperfusion in peripapillary retina even at an early POAG stage and can serve as an important diagnostic method for early glaucoma detection // Russian Ophthalmological Journal, 2016; 3: 34-41. doi: 10.21516/2072-0076-2016-9-3-34-41.

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The authors declare that there are no conflicts of interest present.