helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2020-13-2-71-77helmholtzeyeinstitute-435Research ArticleЭКСПЕРИМЕНТАЛЬНО-ЛАБОРАТОРНЫЕ ИССЛЕДОВАНИЯEXPERIMENTAL AND LABORATORY STUDIESОценка схем консервативного лечения бактериальных язв роговицы с применением глюкокортикостероидного препарата в экспериментеExperimental evaluation of bacterial corneal ulcer treatment plans using glucocorticosteroidНероевВ. В.NeroevV. V.

Владимир Владимирович Нероев – академик РАН, д-р мед. наук, профессор, директор

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Vladimir V. Neroev – Academician of RAS, Dr. of Med. Sci., Professor, director

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

ЯниЕ. В.YaniE. V.

Елена Владимировна Яни – канд. мед. наук, руководитель отдела инфекционных и аллергических заболеваний глаз

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Elena V. Yani – Cand. of Med. Sci., department of infectious and allergic eye diseases, head

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

ГоликоваВ. А.GolikovaV. A.

Виктория Алексеевна Голикова – аспирант отдела инфекционных и аллергических заболеваний глаз

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Viktorija A. Golikova – PhD student, department of infectious and allergic eye diseases

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

viktorydeva@gmail.comПоздняковаВ. В.PozdnyakovaV. V.

Виктория Викторовна Позднякова – канд. мед. наук, старший научный сотрудник отдела инфекционных и аллергических заболеваний глаз

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Viktorija V. Pozdnyakova – Cand. of Med. Sci., senior researcher department of infectious and allergic eye diseases

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

ФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииРоссияHelmholtz National Medical Research Center of Eye DiseasesRussian Federation2020270520201327177Copyright © Нероев В.В., Яни Е.В., Голикова В.А., Позднякова В.В., 20202020Нероев В.В., Яни Е.В., Голикова В.А., Позднякова В.В.Neroev V.V., Yani E.V., Golikova V.A., Pozdnyakova V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/435бактериальная язва роговицыкортикостероидные препаратыэкспериментbacterial corneal ulcercorticosteroid therapyexperimentReferencesКаспарова Е.А. Гнойные язвы роговицы: этиология, патогенез, классификация Вестник офтальмологии. 2015; 131 (5): 87–97.Kasparova E.A. Purulent corneal ulcers: etiology, pathogenesis, classification. Vestnik Oftal’mologii. 2015 Sep-Oct; 131 (5): 87–97 (in Russian).Leibovitch I., Lai T.F., Senarath L., Hsuan J., Selva D. Infectious keratitis in South Australia: emerging resistance to cephazolin. Eur. J. Ophthalmol. 2005; Jan-Feb; 15 (1): 23–6.Leibovitch I., Lai T.F., Senarath L., Hsuan J., Selva D. Infectious keratitis in South Australia: emerging resistance to cephazolin. Eur. J. Ophthalmol. 2005; Jan-Feb; 15 (1): 23–6.Acharya N.R., Srinivasan M., Mascarenhas J., et al. The steroid controversy in bacterial keratitis. Arch. Ophthalmol. 2009 Sep; 127 (9): 10.1001/archophthalmol.2009.221. doi:10.1001/archophthalmol.2009.221Acharya N.R., Srinivasan M., Mascarenhas J., et al. The steroid controversy in bacterial keratitis. Arch. Ophthalmol. 2009 Sep; 127 (9): 10.1001/archophthalmol.2009.221. doi:10.1001/archophthalmol.2009.221Cohen E.J. The case against the use of steroids in the treatment of bacterial keratitis. Arch. Ophthalmol. 2009 Jan; 127 (1): 103–4. doi: 10.1001/archophthalmol.2008.503Cohen E.J. The case against the use of steroids in the treatment of bacterial keratitis. Arch. Ophthalmol. 2009 Jan; 127 (1): 103–4. doi: 10.1001/archophthalmol.2008.503Hindman H.B., Patel S.B., Jun A.S. Rationale for adjunctive topical corticosteroids in bacterial keratitis. Arch. Ophthalmol. 2009; 127: 97–102. doi: 10.1001/archophthalmol.2008.504Hindman H.B., Patel S.B., Jun A.S. Rationale for adjunctive topical corticosteroids in bacterial keratitis. Arch. Ophthalmol. 2009; 127: 97–102. doi: 10.1001/archophthalmol.2008.504Den S., Sotozono C., Kinoshita S., Ikeda T. Efficacy of early systemic betamethasone or cyclosporin A after corneal alkali injury via inflammatory cytokine reduction. Acta Ophthalmol. Scand. 2004; 82: 195–9.Den S., Sotozono C., Kinoshita S., Ikeda T. Efficacy of early systemic betamethasone or cyclosporin A after corneal alkali injury via inflammatory cytokine reduction. Acta Ophthalmol. Scand. 2004; 82: 195–9.Yi K., Chung T.Y., Hyon J.Y., et al. Combined treatment with antioxidants and immunosuppressants on cytokine release by human peripheral blood mononuclear cells — chemically injured keratocyte reaction. Mol. Vis. 2011; 17: 2665–71. PMID:22065919Yi K., Chung T.Y., Hyon J.Y., et al. Combined treatment with antioxidants and immunosuppressants on cytokine release by human peripheral blood mononuclear cells — chemically injured keratocyte reaction. Mol. Vis. 2011; 17: 2665–71. PMID:22065919Williams R.N., Paterson C.A. The influence of topical corticosteroid therapy upon polymorphonuclear leukocyte distribution, vascular integrity and ascorbate levels in endotoxin-induced inflammation of the rabbit eye. Exp. Eye Res. 1987 1987 Feb; 44 (2): 191–8. doi:10.1016/s0014-4835(87)80003-9Williams R.N., Paterson C.A. The influence of topical corticosteroid therapy upon polymorphonuclear leukocyte distribution, vascular integrity and ascorbate levels in endotoxin-induced inflammation of the rabbit eye. Exp. Eye Res. 1987 1987 Feb; 44 (2): 191–8. doi:10.1016/s0014-4835(87)80003-9Chung J.H., Kang Y.G., Kim H.J. Effect of 0.1% dexamethasone on epithelial healing in experimental corneal alkali wounds: morphological changes during the repair process. Graefes Arch. Clin. Exp. Ophthalmol. 1998; 236: 537–45. doi:10.1007/s004170050118Chung J.H., Kang Y.G., Kim H.J. Effect of 0.1% dexamethasone on epithelial healing in experimental corneal alkali wounds: morphological changes during the repair process. Graefes Arch. Clin. Exp. Ophthalmol. 1998; 236: 537–45. doi:10.1007/s004170050118Tomas-Barberan S., Fagerholm P. Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy. Acta Ophthalmol. Scand. 1999; 77: 135–8. doi:10.1034/j.1600-0420.1999.770203.xTomas-Barberan S., Fagerholm P. Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy. Acta Ophthalmol. Scand. 1999; 77: 135–8. doi:10.1034/j.1600-0420.1999.770203.xGritz D.C., Kwitko S., Trousdale M.D., Gonzalez V.H., McDonnell P.J. Recurrence of microbial keratitis concomitant with antiinflammatory treatment in an animal model. Cornea. 1992; 11: 404–8. doi:10.1097/00003226-199209000-00008Gritz D.C., Kwitko S., Trousdale M.D., Gonzalez V.H., McDonnell P.J. Recurrence of microbial keratitis concomitant with antiinflammatory treatment in an animal model. Cornea. 1992; 11: 404–8. doi:10.1097/00003226-199209000-00008Gritz D.C., Lee T.Y., Kwitko S., McDonnell P.J. Topical anti-inflammatory agents in an animal model of microbial keratitis. Arch. Ophthalmol. 1990; 108: 1001–5. doi:10.1001/archopht.1990.01070090103049Gritz D.C., Lee T.Y., Kwitko S., McDonnell P.J. Topical anti-inflammatory agents in an animal model of microbial keratitis. Arch. Ophthalmol. 1990; 108: 1001–5. doi:10.1001/archopht.1990.01070090103049Herretes S., Wang X., Reyes J.M. Topical corticosteroids as adjunctive therapy for bacterial keratitis. Cochrane Database Syst. Rev. 2014 Oct. doi: 10.1002/14651858.CD005430.pub3Herretes S., Wang X., Reyes J.M. Topical corticosteroids as adjunctive therapy for bacterial keratitis. Cochrane Database Syst. Rev. 2014 Oct. doi: 10.1002/14651858.CD005430.pub3Blair J., Hodge W., Al-Ghamdi S., et al. Comparison of antibioticonly and antibiotic-steroid combination treatment in corneal ulcer patients: double-blinded randomized clinical trial. Can. J. Ophthalmol. 2011; 46: 40–5. doi: 10.3129/i10-054Blair J., Hodge W., Al-Ghamdi S., et al. Comparison of antibioticonly and antibiotic-steroid combination treatment in corneal ulcer patients: double-blinded randomized clinical trial. Can. J. Ophthalmol. 2011; 46: 40–5. doi: 10.3129/i10-054Carmichael T.R., Gelfand Y., Welsh N.H. Topical steroids in the treatment of central and paracentral corneal ulcers. Br. J. Ophthalmol. 1990; 74: 528–31. doi:10.1136/bjo.74.9.528Carmichael T.R., Gelfand Y., Welsh N.H. Topical steroids in the treatment of central and paracentral corneal ulcers. Br. J. Ophthalmol. 1990; 74: 528–31. doi:10.1136/bjo.74.9.528Srinivasan M., Lalitha P., Mahalakshmi R., et al. Corticosteroids for bacterial corneal ulcers. Br. J. Ophthalmol. 2009; 93: 198–202. doi:10.1136/bjo.2008.147298Srinivasan M., Lalitha P., Mahalakshmi R., et al. Corticosteroids for bacterial corneal ulcers. Br. J. Ophthalmol. 2009; 93: 198–202. doi:10.1136/bjo.2008.147298Srinivasan M., Mascarenhas J., Rajaraman R., et al. Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). Arch. Ophthalmol. 2012; 130: 143–50. doi:10.1001/archophthalmol.2011.315Srinivasan M., Mascarenhas J., Rajaraman R., et al. Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). Arch. Ophthalmol. 2012; 130: 143–50. doi:10.1001/archophthalmol.2011.315Бикбов М.М., Никитин Н.А., Суркова В.К., Зайнуллина Н.Б. Способ моделирования бактериального кератита. Патент РФ на изобретение № 248084.Bikbov M.M., Nikitin N.A., Surkova V.K., Zaynullina N.B. Method of modeling bacterial keratitis. Patent RF, N 248084 (in Russian).

The authors declare that there are no conflicts of interest present.