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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2021-14-1-69-73</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-586</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНО-ЛАБОРАТОРНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERIMENTAL AND LABORATORY STUDIES</subject></subj-group></article-categories><title-group><article-title>Изменчивость микробиологического профиля при язвах роговицы</article-title><trans-title-group xml:lang="en"><trans-title>The variability of the microbial profile of corneal ulcers</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Магеррамов</surname><given-names>П. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Maharramov</surname><given-names>P. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Полад Магеррам оглы Магеррамов — кандидат медицинских наук, младший научный сотрудник научно-информационного и организационнометодического отдела.</p><p>Ул. Джавадхана, д. 32/15, Баку, AZ1114</p></bio><bio xml:lang="en"><p>Polad M. Maharramov — Cand. of Med. Sci., junior researcher of the scientific-informational and organizational-methodological department.</p><p>32/15, Javadkhan St., Baku, AZ 1114</p></bio><email xlink:type="simple">minaragamid@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гулиева</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Guliyeva</surname><given-names>M. H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минара Гамид гызы Гулиева — кандидат медицинских наук, руководитель научнообразовательного центра.</p><p>Ул. Джавадхана, д. 32/15, Баку, AZ1114</p></bio><bio xml:lang="en"><p>Minara H. Guliyeva — Cand. of Med. Sci., head of the scientific and educational center.</p><p>32/15, Javadkhan St., Baku, AZ 1114</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный центр офтальмологии им. акад. Зарифы Алиевой Минздрава Азербайджанской Республики</institution><country>Азербайджан</country></aff><aff xml:lang="en"><institution>National Centre of Ophthalmology named after Acad. Zarifa Aliyeva, Ministry of Health of Azerbaijan Republic</institution><country>Azerbaijan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>19</day><month>03</month><year>2021</year></pub-date><volume>14</volume><issue>1</issue><fpage>69</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Магеррамов П.М., Гулиева М.Г., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Магеррамов П.М., Гулиева М.Г.</copyright-holder><copyright-holder xml:lang="en">Maharramov P.M., Guliyeva M.H.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/586">https://roj.igb.ru/jour/article/view/586</self-uri><abstract><p>Цель работы — изучить особенности микробиологического профиля язвы роговицы в зависимости от демографической и клинической характеристики пациентов.</p><sec><title>Материал и методы</title><p>Материал и методы. Обследованы 97 пациентов (114 глаз), в том числе 65 мужчин и 32 женщины, в возрасте от 15 до 87 лет (24,7 % в возрасте 50–59 лет, 27,8 % в возрасте 60–69 лет и 19,7% в возрасте 70 лет и старше) с диагнозом «язва роговицы» (у 80 пациентов односторонняя, у 17 — двусторонняя). Для определения микрофлоры язвы роговицы проведен микробиологический анализ соскобов. Существенность половозрастных и клинических различий структуры микробиологического профиля оценивалась критерием χ².</p></sec><sec><title>Результаты</title><p>Результаты. Наиболее часто выявлялись грамположительные микроорганизмы: в 25,3 % случаев — Staphylococcus epidermidis, в 21,7 % — Streptococcus pneumoniae, в 16,3 % — Streptococcus viridians и в 7,8 % — Staphylococcus aureus. Грамнегативная микрофлора (Pseudomonas aeruginosa) выявлена в 22,3 % случаев. Грибки обнаружены в 6,6 % глаз.</p></sec><sec><title>Заключение</title><p>Заключение. Микробиологический профиль язвы роговицы зависит от возраста пациента, локализации, размера и глубины повреждения, а также от наличия осложнений. Тяжелые и осложненные формы язвы роговицы (размеры ˃ 5 мм, глубина — более 2/3 толщины роговицы) часто ассоциируются с выявлением более одного вида микроорганизмов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose. To study the microbiological profile of corneal ulcers depending on demographic and clinical characteristics of patients.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. 97 patients (114 eyes) (65 men and 32 women) diagnosed with corneal ulcer were tested. 80 patients had unilateral and 17 bilateral ulcers. The patients’ age varied from 15 to 87 years (24.7 % aged 50–59, 27.8 % aged 60–69, and 19.7 % aged 70 or older). All patients were examined for the microbiological profile of corneal scrapings to determine the microbial flora of the corneal ulcer. The significance of gender, age and clinical differences found in the structure of the microbiological profile was evaluated by the the χ² criterion.</p></sec><sec><title>Results</title><p>Results. Gram-positive microorganisms were among the most frequently detected: Staphylococcus epidermidis in 25.3 % of cases, Streptococcus pneumoniae in 21.7 % of cases, Streptococcus viridians in 16.3 % of cases, and Staphylococcus aureus in 7,8 % of cases. Gram-negative microbial flora (Pseudomonas aeruginosa) was revealed in 22.3 % of cases, while fungi were identified in 6.6 % of cases.</p></sec><sec><title>Conclusion</title><p>Conclusion. The microbiological profile of corneal ulcer depends on the patient’s age, localization, size and depth of the lesion, as well as the presence of complication. Severe and complicated forms of corneal ulcer (sized ˃5 mm, depth of the lesion exceeding two thirds of corneal thickness) are often associated with the detection of more than one type of microorganism.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>язва роговицы</kwd><kwd>микробиологический профиль</kwd><kwd>изменчивость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>corneal ulcer</kwd><kwd>microbiological profile</kwd><kwd>variability</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Турчин Н.В. Особенности цитокинового профиля слезной жидкости больных язвой роговицы при условии разных методов хирургической коррекции. Oftalmologiya. 2015; 2 (18): 47–52.</mixed-citation><mixed-citation xml:lang="en">Turchin N.V. Features of the cytokıne profıle of the tear lıquıd ın the patıents wıth ulcer of the cornea ın the case of dıfferent methods of surgıcal correctıon. 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