helmholtzeyeinstituteРоссийский офтальмологический журналRussian Ophthalmological Journal2072-00762587-5760Real time Publishers10.21516/2072-0076-2021-14-2-69-75helmholtzeyeinstitute-662Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУFOR OPHTHALMOLOGY PRACTITIONERSСмешанный (комбинированный) фенотип поздней стадии возрастной макулярной дегенерацииMixed (combined) phenotype of the late stage of age-related macular degenerationНероеваН. В.NeroevaN. V.

Наталия Владимировна Нероева— канд. мед. наук, врач отдела патологии сетчатки и зрительного нерва

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Natalia V. Neroeva— Cand. of Med. Sci., ophthalmologist, department of retinal and optic nerve pathology

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

НероевВ. В.NeroevV. V.

Владимир Владимирович Нероев— академик РАН, д-р мед. наук, профессор, директор, заведующий кафедрой глазных болезней факультета дополнительного профессионального образования

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

 ул. Делегатская, д.20, стр.1, Москва, 127473

Vladimir V. Neroev— Academician of RAS, Dr. of Med. Sci., professor, director, head of eye diseases chair of the faculty of additional professional education

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

 20, Bldg.1, Delegatskaya St., Moscow, 127473

РябинаМ. В.RyabinaM. V.

Марина Владимировна Рябина — канд. мед. наук, старший научный сотрудник отдела патологии сетчатки и зрительного нерва

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Marina V. Ryabina — Cand. of Med. Sci., senior researcher, department of retinal and optic nerve pathology

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

КармоковаА. Г.KarmokovaA. G.

Асият Гисовна Кармокова— аспирант отдела патологии сетчатки и зрительного нерва

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Asiyat G. Karmokova — PhD, department of retinal and optic nerve pathology

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

ЛосановаО. А.LosanovaO. A.

Оксана Арсеновна Лосанова— аспирант отдела патологии сетчатки и зрительного нерва

ул. Садовая-Черногрязская, д. 14/19, Москва, 105062

Oksana A. Losanova— PhD, department of retinal and optic nerve pathology

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062

ФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииРоссияHelmholtz National Medical Research Center of Eye DiseasesRussian FederationФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава России; ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияHelmholtz National Medical Research Center of Eye Diseases; A.I. Evdokimov Moscow State University of Medicine and DentistryRussian Federation2021190620211426975Copyright © Нероева Н.В., Нероев В.В., Рябина М.В., Кармокова А.Г., Лосанова О.А., 20212021Нероева Н.В., Нероев В.В., Рябина М.В., Кармокова А.Г., Лосанова О.А.Neroeva N.V., Neroev V.V., Ryabina M.V., Karmokova A.G., Losanova O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://roj.igb.ru/jour/article/view/662

Применение мультимодальной визуализации структур хориоретинального комплекса позволило выделить смешанный, или комбинированный, фенотип поздней стадии возрастной макулярной дегенерации (ВМД). Своевременное распознавание данной формы ВМД имеет принципиальное значение для точной диагностики, выбора тактики лечения и прогнозирования его функционального результата. В статье представлены два клинических случая — два различных варианта развития смешанного фенотипа поздней стадии ВМД. В одном случае длительное существование «географической атрофии» (ГА) осложнилось развитием хориоидальной неоваскуляризации, в другом — ГА появилась на фоне лечения влажной ВМД.

With multimodal visualization of the chorioretinal complex structures using modern research methods, it was possible to isolatea mixed, or combined, phenotype of the late stage of age-related macular degeneration (AMD). Early detection of this AMD form is of vital importance not only for accurate diagnosis, but for choosing optimal management tactics for patients. The paper presents two clinical cases with different variants of the development of the mixed phenotype of the late AMD stage. In one case, the long-lasting “geographic atrophy” (GA) was complicated by the development of choroidal neovascularization, while in the other case GA appeared during the treatment of wetAMD.

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The authors declare that there are no conflicts of interest present.