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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2021-14-2-85-89</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-665</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Побочные эффекты аналогов простагландинов,  используемых в офтальмологической практике</article-title><trans-title-group xml:lang="en"><trans-title>Adverse effects of prostaglandin analogues used in  ophthalmological practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казанова</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kazanova</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлана Юрьевна Казанова — канд. мед. наук, заведующая офтальмологическим консультативно-диагностическим отделением № 1 (глаукомное отделение)</p></bio><bio xml:lang="en"><p>Svetlana Yu. Kazanova — Cand. of Med. Sci., head of the ophthalmological department of consultative and diagnostic No.1 (glaucoma department)</p><p>52, Ave. Oktyabrya, Yaroslavl, 150040</p></bio><email xlink:type="simple">kazanova3112@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБКУЗ ЯО «Центральная городская больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central City Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2021</year></pub-date><volume>14</volume><issue>2</issue><fpage>85</fpage><lpage>89</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Казанова С.Ю., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Казанова С.Ю.</copyright-holder><copyright-holder xml:lang="en">Kazanova S.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/665">https://roj.igb.ru/jour/article/view/665</self-uri><abstract><p>Аналоги простагландинов — класс эффективных гипотензивных препаратов для лечения глаукомы — обладают хорошим профилем безопасности в плане системного воздействия, но достаточно большим количеством местных побочных эффектов. Они могут ухудшать качество жизни пациентов с глаукомой, а также снижать приверженность лечению вследствие физического и психологического дискомфорта. В обзоре представлены литературные данные и клинические примеры из личной практики.</p></abstract><trans-abstract xml:lang="en"><p>Prostaglandin analogues are a class of antihypertensive drugs for glaucoma treatment which are systematically safe but have a sufficiently large number of local side effects. These effects may worsen the quality of life of patients with glaucoma and reducetheir adherence to treatment routines due to physical and psychological discomfort. The review presents literature data and clinical cases fromthe author’s own medical practice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гиперемия конъюнктивы</kwd><kwd>рост ресниц</kwd><kwd>изменение цвета радужки</kwd><kwd>простагландин-ассоциированная  периорбитопатия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>conjunctival hyperemia</kwd><kwd>eyelash growth</kwd><kwd>iris color change</kwd><kwd>prostaglandin-associated periorbitopathy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">European Glaucoma Society. Terminology and guidelines for glaucoma. 4th ed. Savona: Italy PubliComm; 2014.</mixed-citation><mixed-citation xml:lang="en">European Glaucoma Society. Terminology and guidelines for glaucoma. 4th ed. Savona: Italy PubliComm; 2014.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Егоров Е.А., Еричев В.П. Медикаментозное гипотензивное лечение глаукомы. В кн.: Егоров Е.А., ред. Глаукома. Национальное руководство. Москва: ГЭОТАР-Медиа; 2013: 427–67.</mixed-citation><mixed-citation xml:lang="en">Egorov E.A., Erichev V.P.Medicamental antihypertensive treatment of glaucoma. In: Egorov E.A., ed. Glauсoma. Nacional Guidelines. Moscow: GEOTAR-Media; 2013: 427–67 (in Russian)].</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Weinreb R.N., Kashiwagi K., Kashiwagi F., Tsukahara S., Lindsey J.D. Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells. Invest. Ophthalmol. Vis. Sci. 1997; 38 (13): 2772–80.</mixed-citation><mixed-citation xml:lang="en">Weinreb R.N., Kashiwagi K., Kashiwagi F., Tsukahara S., Lindsey J.D. Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells. Invest. Ophthalmol. Vis. Sci. 1997; 38 (13): 2772–80.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sharif N.A., Kelly C.R., Crider J.Y. Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and ot her prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor. J. Ocul. Pharmacol. Ther. 2002; 18 (4): 313–24. doi: 10.1089/10807680260218489</mixed-citation><mixed-citation xml:lang="en">Sharif N.A., Kelly C.R., Crider J.Y. Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and ot her prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor. J. Ocul. Pharmacol. Ther. 2002; 18 (4): 313–24. doi: 10.1089/10807680260218489</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sharif N.A., Kelly C.R., Crider J.Y. Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues. Invest. Ophthalmol. Vis. Sci. 2003; 44 (2): 715–21. doi: 10.1167/iovs.02-0323</mixed-citation><mixed-citation xml:lang="en">Sharif N.A., Kelly C.R., Crider J.Y. Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues. Invest. Ophthalmol. Vis. Sci. 2003; 44 (2): 715–21. doi: 10.1167/iovs.02-0323</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ota T., Aihara M., Narumiya S., Araie M.The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice. Invest. Ophthalmol. Vis. Sci. 2005; 46 (11): 4159–63. doi: 10.1167/iovs.05-0494</mixed-citation><mixed-citation xml:lang="en">Ota T., Aihara M., Narumiya S., Araie M.The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice. Invest. Ophthalmol. Vis. Sci. 2005; 46 (11): 4159–63. doi: 10.1167/iovs.05-0494</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Toris C.B., Gabelt B.T., Kaufman P.L. Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction. Surv. Ophthalmol. 2008; 53 (Suppl 1): S107–20. doi: 10.1016/j.survophthal.2008.08.010</mixed-citation><mixed-citation xml:lang="en">Toris C.B., Gabelt B.T., Kaufman P.L. Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction. Surv. Ophthalmol. 2008; 53 (Suppl 1): S107–20. doi: 10.1016/j.survophthal.2008.08.010</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lim K.S., Nau C.B., O'Byrne M.M., et al. Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study. Ophthalmology. 2008; 115 (5): 790-5.e4. doi: 10.1016/j.ophtha.2007.07.002</mixed-citation><mixed-citation xml:lang="en">Lim K.S., Nau C.B., O'Byrne M.M., et al. Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study. Ophthalmology. 2008; 115 (5): 790-5.e4. doi: 10.1016/j.ophtha.2007.07.002</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Neacsu A.M. Receptors involved in the mechanism of action of topical prostaglandins. [Article in Romanian]. Oftalmologia. 2009; 53 (2): 3–7.</mixed-citation><mixed-citation xml:lang="en">Neacsu A.M. Receptors involved in the mechanism of action of topical prostaglandins. [Article in Romanian]. Oftalmologia. 2009; 53 (2): 3–7.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Shah M., Lee G., Lefebvre D.R., et al.A cross-sectional survey of the association between bilateral topical prostaglandin analogue use and ocular adnexal features. PLoS One. 2013 ; 8 (5):e61638. doi: 10.1371/journal.pone.0061638</mixed-citation><mixed-citation xml:lang="en">Shah M., Lee G., Lefebvre D.R., et al.A cross-sectional survey of the association between bilateral topical prostaglandin analogue use and ocular adnexal features. PLoS One. 2013 ; 8 (5):e61638. doi: 10.1371/journal.pone.0061638</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Alm A., Grierson I., Shields M.B. Side effects associated with prostaglandin analog therapy. Surv. Ophthalmol. 2008; 53 (Suppl 1): S93–105. doi: 10.1016/j.survophthal.2008.08.004</mixed-citation><mixed-citation xml:lang="en">Alm A., Grierson I., Shields M.B. Side effects associated with prostaglandin analog therapy. Surv. Ophthalmol. 2008; 53 (Suppl 1): S93–105. doi: 10.1016/j.survophthal.2008.08.004</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Варфоломеев С.Д. Простагландины — новый тип биологических регулято-ров. Соросовский образовательный журнал. 1996; 1: 40–7.</mixed-citation><mixed-citation xml:lang="en">Varfolomeev S.D.Prostaglandins - a new type of biological regulators. Sorosovskij obrazovatel'nyj zhurnal. 1996; 1: 40–7 (in Russian)].</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Егорова Т.Е. Простагландины в лечении глаукомы. РМЖ. Клиническая офтальмология. 2004; 5 (3): 127–31.</mixed-citation><mixed-citation xml:lang="en">Egorova T.E. Prostaglandins in glaucoma treatment. RMZh. Klinicheskaja oftal'mologija. 2004; 5 (3): 127–31 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Еричев В.П., Зинина В.С. Латанопрост в гипотензивной терапии глау-комы. Вестник офтальмологии. 2018; 4: 91–9.</mixed-citation><mixed-citation xml:lang="en">Erichev V.P., Zinina V.S. Latanoprost in hypotensive therapy of glaucoma. Vestnik oftal'mologii. 2018; 4: 91–9 (in Russian). doi: 10.17116/oftalma201813404191]</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">European Glaucoma Society. Terminology and guidelines for glaucoma. 2th ed. Savona: Italy DOGMA; 2003.</mixed-citation><mixed-citation xml:lang="en">European Glaucoma Society. Terminology and guidelines for glaucoma. 2th ed. Savona: Italy DOGMA; 2003.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Honrubia F., Garc a-S nchez J., Polo V., de la Casa J.M., Soto J. Conjunctival hyperaemia with the use of latanoprost versus other prostaglandin analogues in patients with ocular hypertension or glaucoma: a meta-analysis of randomised clinical trials. Br. J. Ophthalmol. 2009; 93 (3): 316–21. doi: 10.1136/bjo.2007.135111</mixed-citation><mixed-citation xml:lang="en">Honrubia F., Garc a-S nchez J., Polo V., de la Casa J.M., Soto J. Conjunctival hyperaemia with the use of latanoprost versus other prostaglandin analogues in patients with ocular hypertension or glaucoma: a meta-analysis of randomised clinical trials. Br. J. Ophthalmol. 2009; 93 (3): 316–21. doi: 10.1136/bjo.2007.135111</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hommer A., Kimmich F. Switching patients from preserved prostaglandin-analog monotherapy to preservative-free tafluprost. Clinical Ophthalmology. 2011; 5: 623–31. doi: 10.2147/opth.s17876</mixed-citation><mixed-citation xml:lang="en">Hommer A., Kimmich F. Switching patients from preserved prostaglandin-analog monotherapy to preservative-free tafluprost. Clinical Ophthalmology. 2011; 5: 623–31. doi: 10.2147/opth.s17876</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Law S.K.Bimatoprost in the treatment of eyelash hypotrichosis. Clin. Ophthalmol. 2010; 26 (4): 349–58. doi: 10.2147/opth.s6480</mixed-citation><mixed-citation xml:lang="en">Law S.K.Bimatoprost in the treatment of eyelash hypotrichosis. Clin. Ophthalmol. 2010; 26 (4): 349–58. doi: 10.2147/opth.s6480</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Johnstone M.A., Albert D.M.Prostaglandin-induced hair growth. Surv. Ophthalmol. 2002; 47 (Suppl 1): S185–202. doi: 10.1016/s0039-6257(02)00307-7</mixed-citation><mixed-citation xml:lang="en">Johnstone M.A., Albert D.M.Prostaglandin-induced hair growth. Surv. Ophthalmol. 2002; 47 (Suppl 1): S185–202. doi: 10.1016/s0039-6257(02)00307-7</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Blume-Peytavi U., Lönnfors S., Hillmann K., Garcia Bartels N. A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1 % on hair growth and pigmentation in healthy volunteers with androgenetic alopecia. J. Am. Acad. Dermatol. 2012; 66 (5): 794–800. doi: 10.1016/j.jaad.2011.05.026</mixed-citation><mixed-citation xml:lang="en">Blume-Peytavi U., Lönnfors S., Hillmann K., Garcia Bartels N. A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1 % on hair growth and pigmentation in healthy volunteers with androgenetic alopecia. J. Am. Acad. Dermatol. 2012; 66 (5): 794–800. doi: 10.1016/j.jaad.2011.05.026</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Jones D. Enhanced eyelashes: prescription and over-the-counter options. Aesthetic Plast. Surg. 2011; 35 (1): 116–21. doi: 10.1007/s00266-010-9561-3</mixed-citation><mixed-citation xml:lang="en">Jones D. Enhanced eyelashes: prescription and over-the-counter options. Aesthetic Plast. Surg. 2011; 35 (1): 116–21. doi: 10.1007/s00266-010-9561-3</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Barrón-Hernández Y.L., Tosti A.Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia. Expert. Opin. Investig. Drugs. 2017; 26 (4): 515–22. doi: 10.1080/13543784.2017.1303480</mixed-citation><mixed-citation xml:lang="en">Barrón-Hernández Y.L., Tosti A.Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia. Expert. Opin. Investig. Drugs. 2017; 26 (4): 515–22. doi: 10.1080/13543784.2017.1303480</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Grierson I., Jonsson M., Cracknell K. Latanoprost and pigmentation. Jpn. J. Ophthalmol. 2004; 48 (6): 602–12. doi: 10.1007/s10384-004-0110-y</mixed-citation><mixed-citation xml:lang="en">Grierson I., Jonsson M., Cracknell K. Latanoprost and pigmentation. Jpn. J. Ophthalmol. 2004; 48 (6): 602–12. doi: 10.1007/s10384-004-0110-y</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеев И.Б., Страхов В.В., Мельникова Н.В., Попова А.А.Изменения фиброзной оболочки глаза у пациентов с впервые выявленной первичной открытоугольной глаукомой. Национальный журнал глаукома. 2016; 15 (1): 13–24.</mixed-citation><mixed-citation xml:lang="en">Alekseev I.B., Strakhov V.V., Mel'nikova N.V., Popova A.A. Changes in the fibrous tunic of the eye in patients with newly diagnosed primary open-angle glaucoma. Nacional'nyj zhurnal glaukoma. 2016; 15 (1): 13–24 (in Russian)].</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Nordmann J.P., Auzanneau N., Ricard S., Berdeaux G. Vision related quality of life and topical glaucoma treatment side effects. Health Qual Life Outcomes. 2003; 10 (1):75. doi: 10.1186/1477-7525-1-75</mixed-citation><mixed-citation xml:lang="en">Nordmann J.P., Auzanneau N., Ricard S., Berdeaux G. Vision related quality of life and topical glaucoma treatment side effects. Health Qual Life Outcomes. 2003; 10 (1):75. doi: 10.1186/1477-7525-1-75</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Белогурова А.В., Эскина Э.Н., Оганезова Ж.Г. Гипотензивный эффект и переносимость аналогов простагландинов у пациентов с первичной открытоугольной глаукомой и офтальмогипертензией как факторы риска прогрессирования глаукомы. РМЖ. Клиническая офтальмология. 2019; 19 (1): 21–6.</mixed-citation><mixed-citation xml:lang="en">Belogurova A.V., Eskina E.N., Oganezova Zh.G.IOP-lowering effect and tolerability of prostaglandin analogues in primary open angleglaucoma and ocular hypertension as risk factors for glaucoma progression. RMZh. Klinicheskaja oftal'mologija. 2019; 19 (1): 21–6 (in Russian). doi: 10.21689/2311-7729-2019-19-1-21-26]</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Астахов Ю.С., Нечипоренко П.А. Аналоги простагландинов: прошлое, настоящее и будущее. Офтальмологические ведомости. 2017; 10 (1): 40–52.</mixed-citation><mixed-citation xml:lang="en">Astakhov Yu.S., Nechiporenko P.A.Prostaglandin analogues: past, present, and future. Oftal'mologicheskie vedomosti. 2017; 10 (1): 40–52 (in Russian). doi: 10.17816/OV10140-52]</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Chiba T., Kashiwagi K., Kogure S., et al. Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients. J. Glaucoma. 2001; 10 (5): 406–10. doi: 10.1097/00061198-200110000-00008</mixed-citation><mixed-citation xml:lang="en">Chiba T., Kashiwagi K., Kogure S., et al. Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients. J. Glaucoma. 2001; 10 (5): 406–10. doi: 10.1097/00061198-200110000-00008</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Азаматова Г.А., Арсланова А.И., Абоимова Е.В. Гиперпигментация радужки на фоне лечения аналогами простагландинов. Медицинский вестник Башкортостана. 2016; 11 (1): 143–5.</mixed-citation><mixed-citation xml:lang="en">Azamatova G.A., Arslanova A.I., Aboimova E.V. Iris hyperpigmentation during treatment with prostaglandin analogues. Medicinskij vestnik Bashkortostana. 2016; 11 (1): 143–5 (in Russian)].</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Camras C.B., Neely D.G., Weiss E.L., et al. Latanoprost-induced iris color darkening: a case report with long-term follow-up. J. Glaucoma. 2000; 9 (1): 95–8. doi: 10.1097/00061198-200002000-00016</mixed-citation><mixed-citation xml:lang="en">Camras C.B., Neely D.G., Weiss E.L., et al. Latanoprost-induced iris color darkening: a case report with long-term follow-up. J. Glaucoma. 2000; 9 (1): 95–8. doi: 10.1097/00061198-200002000-00016</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Еричев В.П., Якубова Л.В. Клиническая оценка безопасности долгосрочного применения ксалатана (обзор литературы). Глаукома. 2004; 1: 74–81.</mixed-citation><mixed-citation xml:lang="en">Erichev V.P., Jakubova L.V. Clinical safety assessment of the long-term use of xalatan (literature review). Glaukoma. 2004; 1: 74–81 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Wistrand P.J., Stjernschantz J., Olsson K. at al. The incidence and time-course of latanoprost-induced iridial pigmentation as a function of eye color. Surv. Opthtalmol. 1997; 41 (Suppl. 2): S129–38. doi: 10.1016/s0039-6257(97)80020-3</mixed-citation><mixed-citation xml:lang="en">Wistrand P.J., Stjernschantz J., Olsson K. at al. The incidence and time-course of latanoprost-induced iridial pigmentation as a function of eye color. Surv. Opthtalmol. 1997; 41 (Suppl. 2): S129–38. doi: 10.1016/s0039-6257(97)80020-3</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Tsai J.C., Sivak-Callcott J.A., Haik B.G., et al. Latanoprost-induced iris heterochromia and open-angle glaucoma: a clinicopathologic report. J. Glaucoma. 2001; 10 (5): 411–3. doi: 10.1097/00061198-200110000-00009</mixed-citation><mixed-citation xml:lang="en">Tsai J.C., Sivak-Callcott J.A., Haik B.G., et al. Latanoprost-induced iris heterochromia and open-angle glaucoma: a clinicopathologic report. J. Glaucoma. 2001; 10 (5): 411–3. doi: 10.1097/00061198-200110000-00009</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Zhan G., Toris C., Camras C., et al. Prostaglandin-induced iris color darkening: an experimental model. Arch. Opthtalmol. 1998; 116 (8): 1065–8. doi:10.1001/archopht.116.8.1065</mixed-citation><mixed-citation xml:lang="en">Zhan G., Toris C., Camras C., et al. Prostaglandin-induced iris color darkening: an experimental model. Arch. Opthtalmol. 1998; 116 (8): 1065–8. doi:10.1001/archopht.116.8.1065</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Mancino R., Di Carlo E., Napoli D., еt al.Anterior segment Optical Coherence Tomography Analysis of iris morphometric changes induced by prostaglandin analogues treatment in patients with primary open angle glaucoma or ocular hypertension. Open Ophthalmol. J. 2018; 29 (12): 110–20. doi: 10.2174/1874364101812010110</mixed-citation><mixed-citation xml:lang="en">Mancino R., Di Carlo E., Napoli D., еt al.Anterior segment Optical Coherence Tomography Analysis of iris morphometric changes induced by prostaglandin analogues treatment in patients with primary open angle glaucoma or ocular hypertension. Open Ophthalmol. J. 2018; 29 (12): 110–20. doi: 10.2174/1874364101812010110</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Коротких С.А., Жиборкин Г.В., Князева Е.С., Русакова Л.В.Эффективность монотерапии пациентов с первичной открытоугольной глаукомой препаратом Биматопрост 0,03 % (Бимоптик). Российский офтальмологический журнал. 2018; 11 (4): 75–9.</mixed-citation><mixed-citation xml:lang="en">Korotkih S.A., Zhiborkin G.V., Knjazeva E.S., Rusakova L.V. The efficiency of monotherapy of patients with primary open-angle glaucoma with Bimatoprost 0.03 % (Bimoptic). Russian ophthalmological journal. 2018; 11 (4): 75–9 (in Russian). doi: 10.21516/2072-0076-2018-11-4-75-79]</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Yam J.C., Yuen N.S., Chan C.W.Bilateral deepening of upper lid sulcus from topical bimatoprost therapy. J. Ocul. Pharmacol. Ther. 2009; 25 (5): 471–2. doi: 10.1089/jop.2009.0019</mixed-citation><mixed-citation xml:lang="en">Yam J.C., Yuen N.S., Chan C.W.Bilateral deepening of upper lid sulcus from topical bimatoprost therapy. J. Ocul. Pharmacol. Ther. 2009; 25 (5): 471–2. doi: 10.1089/jop.2009.0019</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Peplinski L.S., Albiani Smith K.Deepening of lid sulcus from topical bimatoprost therapy. Optom. Vis. Sci. 2004; 81 (8): 574–7. doi: 10.1097/01.opx.0000141791.16683.4a</mixed-citation><mixed-citation xml:lang="en">Peplinski L.S., Albiani Smith K.Deepening of lid sulcus from topical bimatoprost therapy. Optom. Vis. Sci. 2004; 81 (8): 574–7. doi: 10.1097/01.opx.0000141791.16683.4a</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Накакура S., Tabuchi Н., Kiuchi Y. Latanoprost therapy after sunken eyes caused by travoprost or bimatoprost. Optom. Vis. Sci. 2011; 88 (9): 1140–4. doi: 10.1097/OPX.0b013e3182231202</mixed-citation><mixed-citation xml:lang="en">Накакура S., Tabuchi Н., Kiuchi Y. Latanoprost therapy after sunken eyes caused by travoprost or bimatoprost. Optom. Vis. Sci. 2011; 88 (9): 1140–4. doi: 10.1097/OPX.0b013e3182231202</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Tappeiner C., Perren B., Iliev M.E., Frueh B.E., Goldblum D. Orbital fat atrophy in glaucoma patients treated with topical bimatoprost - can bimatoprost cause enophthalmos? [in German]. Klin. Monbl. Augenheilkd. 2008; 225 (5): 443–5. doi: 10.1055/s-2008-1027362</mixed-citation><mixed-citation xml:lang="en">Tappeiner C., Perren B., Iliev M.E., Frueh B.E., Goldblum D. Orbital fat atrophy in glaucoma patients treated with topical bimatoprost - can bimatoprost cause enophthalmos? [in German]. Klin. Monbl. Augenheilkd. 2008; 225 (5): 443–5. doi: 10.1055/s-2008-1027362</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Filippopoulos T., Paula J.S., Torun N., et al. Periorbital changes associated with topical bimatoprost. Ophthalmic. Plast. Reconstr. Surg. 2008; 24 (4): 302–7. doi: 10.1097/IOP.0b013e31817d81df</mixed-citation><mixed-citation xml:lang="en">Filippopoulos T., Paula J.S., Torun N., et al. Periorbital changes associated with topical bimatoprost. Ophthalmic. Plast. Reconstr. Surg. 2008; 24 (4): 302–7. doi: 10.1097/IOP.0b013e31817d81df</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Jayaprakasam A., Ghazi-Nouri S. Periorbital fat atrophy – an unfamiliar side effect of prostaglandin analogues. Orbit. 2010; 29 (6): 357–9. doi: 10.3109/01676830.2010.527028</mixed-citation><mixed-citation xml:lang="en">Jayaprakasam A., Ghazi-Nouri S. Periorbital fat atrophy – an unfamiliar side effect of prostaglandin analogues. Orbit. 2010; 29 (6): 357–9. doi: 10.3109/01676830.2010.527028</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Aihara M., Shirato S., Sakata R. Incidence of deepening of the upper eyelid sulcus after switching from latanoprost to bimatoprost. Jpn. J. Ophthalmol. 2011; 55 (6): 600–4. doi: 10.1007/s10384-011-0075-6</mixed-citation><mixed-citation xml:lang="en">Aihara M., Shirato S., Sakata R. Incidence of deepening of the upper eyelid sulcus after switching from latanoprost to bimatoprost. Jpn. J. Ophthalmol. 2011; 55 (6): 600–4. doi: 10.1007/s10384-011-0075-6</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Rabinowitz M.P., Katz L.J., Moster M.R., et al. Unilateral prostaglandinassociated periorbitopathy: a syndrome involving upper eyelid retraction distinguishable from the aging sunken eyelid. Ophthal. Plast. Reconstr. Surg. 2015; 31 (5): 373–8. doi: 10.1097/IOP.0000000000000351</mixed-citation><mixed-citation xml:lang="en">Rabinowitz M.P., Katz L.J., Moster M.R., et al. Unilateral prostaglandinassociated periorbitopathy: a syndrome involving upper eyelid retraction distinguishable from the aging sunken eyelid. Ophthal. Plast. Reconstr. Surg. 2015; 31 (5): 373–8. doi: 10.1097/IOP.0000000000000351</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Kim H.W., Choi Y.J., Lee K.W., Lee M.J. Periorbital changes associated with prostaglandin analogs in Korean patients. BMC Ophthalmol. 2017; 17 (1): 126. doi: 10.1186/s12886-017-0521-4</mixed-citation><mixed-citation xml:lang="en">Kim H.W., Choi Y.J., Lee K.W., Lee M.J. Periorbital changes associated with prostaglandin analogs in Korean patients. BMC Ophthalmol. 2017; 17 (1): 126. doi: 10.1186/s12886-017-0521-4</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Kucukevcilioglu M., Bayer A., Uysal Y., Altinsoy H.I. Prostaglandin associated periorbitopathy in patients using bimatoprost, latanoprost and travoprost. Clin. Exp. Ophthalmol. 2014; 42 (2): 126–31. doi: 10.1111/ceo.12163</mixed-citation><mixed-citation xml:lang="en">Kucukevcilioglu M., Bayer A., Uysal Y., Altinsoy H.I. Prostaglandin associated periorbitopathy in patients using bimatoprost, latanoprost and travoprost. Clin. Exp. Ophthalmol. 2014; 42 (2): 126–31. doi: 10.1111/ceo.12163</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue K., Shiokawa M., Wakakura M., Tomita G.Deepening of the upper eyelid sulcus caused by 5 types of prostaglandin analogs. J. Glaucoma. 2013; 22 (8): 626–31. doi: 10.1097/IJG.0b013e31824d8d7c</mixed-citation><mixed-citation xml:lang="en">Inoue K., Shiokawa M., Wakakura M., Tomita G.Deepening of the upper eyelid sulcus caused by 5 types of prostaglandin analogs. J. Glaucoma. 2013; 22 (8): 626–31. doi: 10.1097/IJG.0b013e31824d8d7c</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Park J., Cho H.K., Moon J.I.Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn. J. Ophthalmol. 2011; 55 (1): 22–7. doi: 10.1007/s10384-010-0904-z</mixed-citation><mixed-citation xml:lang="en">Park J., Cho H.K., Moon J.I.Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn. J. Ophthalmol. 2011; 55 (1): 22–7. doi: 10.1007/s10384-010-0904-z</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Ung T., Currie Z.I. Periocular changes following long-term administration of latanoprost 0.005%. Ophthalmic. Plast. Reconstr. Surg. 2012; 28 (2): e42-4. doi: 10.1097/IOP.0b013e31821d86a5</mixed-citation><mixed-citation xml:lang="en">Ung T., Currie Z.I. Periocular changes following long-term administration of latanoprost 0.005%. Ophthalmic. Plast. Reconstr. Surg. 2012; 28 (2): e42-4. doi: 10.1097/IOP.0b013e31821d86a5</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Kim J.W.Topical prostaglandin analogue drugs inhibit adipocyte differentiation. Korean J. Ophthalmol. 2014; 28 (3): 257–64. doi: 10.3341/kjo.2014.28.3.257</mixed-citation><mixed-citation xml:lang="en">Kim J.W.Topical prostaglandin analogue drugs inhibit adipocyte differentiation. Korean J. Ophthalmol. 2014; 28 (3): 257–64. doi: 10.3341/kjo.2014.28.3.257</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Higashiyama T., Ohji M.Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy. Clin. Ophthalmol. 2018; 12: 2415–21. doi: 10.2147/OPTH.S187164</mixed-citation><mixed-citation xml:lang="en">Higashiyama T., Ohji M.Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy. Clin. Ophthalmol. 2018; 12: 2415–21. doi: 10.2147/OPTH.S187164</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Aydin S., Işikligil I., Tekşen Y.A., Kir E. Recovery of orbital fat pad prolapsus and deepening of the lid sulcus from topical bimatoprost therapy: 2 case reports and review of the literature. Cutan. Ocul. Toxicol. 2010; 29 (3): 212–6. doi: 10.3109/15569521003796860</mixed-citation><mixed-citation xml:lang="en">Aydin S., Işikligil I., Tekşen Y.A., Kir E. Recovery of orbital fat pad prolapsus and deepening of the lid sulcus from topical bimatoprost therapy: 2 case reports and review of the literature. Cutan. Ocul. Toxicol. 2010; 29 (3): 212–6. doi: 10.3109/15569521003796860</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
