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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">helmholtzeyeinstitute</journal-id><journal-title-group><journal-title xml:lang="ru">Российский офтальмологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Ophthalmological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0076</issn><issn pub-type="epub">2587-5760</issn><publisher><publisher-name>Real time Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21516/2072-0076-2016-9-1-48-55</article-id><article-id custom-type="elpub" pub-id-type="custom">helmholtzeyeinstitute-8</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Вызванные потенциалы сетчатки и зрительной коры при длительном воздействии светодиодного излучения светильников с варьируемыми во времени спектрально-энергетическими характеристиками</article-title><trans-title-group xml:lang="en"><trans-title>Visual Evoked Potentials of the Retina and Visual Cortex after a Prolonged Exposure to the Radiation of LED Fixtures with Variable Spectral Energy Characteristics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нероев</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Neroev</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ушаков</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Ushakov</surname><given-names>I. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зуева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zueva</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Манько</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Manko</surname><given-names>O. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лантух</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Lantukh</surname><given-names>E. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цапенко</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsapenko</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смолеевский</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Smoleevsky</surname><given-names>A. E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Назарова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nazarova</surname><given-names>G. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Московский НИИ глазных болезней им. Гельмгольца» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Helmholtz Research Institute of Eye Diseases, Moscow, Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУН ГНЦ РФ «Институт медико-биологических проблем РАН»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Офтальмологический центр «Доктор Визус», Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Doctor Visus Ophthalmic Center, Moscow, Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2018</year></pub-date><volume>9</volume><issue>1</issue><fpage>48</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нероев В.В., Ушаков И.Б., Зуева М.В., Манько О.М., Лантух Е.П., Цапенко И.В., Смолеевский А.Е., Назарова Г.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Нероев В.В., Ушаков И.Б., Зуева М.В., Манько О.М., Лантух Е.П., Цапенко И.В., Смолеевский А.Е., Назарова Г.А.</copyright-holder><copyright-holder xml:lang="en">Neroev V.V., Ushakov I.B., Zueva M.V., Manko O.M., Lantukh E.P., Tsapenko I.V., Smoleevsky A.E., Nazarova G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://roj.igb.ru/jour/article/view/8">https://roj.igb.ru/jour/article/view/8</self-uri><abstract><p>Цель работы - определение характера изменений биоэлектрической активности сетчатки и зрительной коры при длительном нахождении человека в замкнутом пространстве с искусственным освещением, создаваемым светодиодными (СД) лампами с изменяемыми спектрально-энергетическими характеристиками. Кроме комплекса стандартных офтальмологических исследований, регистрировали электроретинограмму (ЭРГ) на диффузные вспышки, паттерн-реверсирующие и мультифокальные стимулы, а также зрительные вызванные корковые потенциалы (ЗВП) с помощью диагностической системы RETI port/scan 21. Исследования проведены у четырех практически здоровых добровольцев до и после 11-суточного гермокамерного эксперимента, имитирующего условия космических летательных аппаратов. Показано, что длительное нахождение человека в условиях замкнутого СД освещения, создаваемого источниками с высокой коррелированной цветовой температурой (КЦТ), не оказывает выраженного негативного воздействия на функцию сетчатки. Изменения амплитуды ЭРГ и ЗВП были незначительными, но имели специфику, ассоциированную с историей предыдущих травм или функциональных нарушений. По данным ЗВП на реверсирующий шахматный паттерн, характерным признаком изменения активности зрительной системы у всех участников было раздвоение пика Р100, возможно, связанное с темпоральным разобщением активности зрительных каналов. Таким образом, искусственное освещение СД светом с высокой КЦТ может оказывать влияние на функциональную активность сетчатки и зрительной коры, характер которого, по-видимому, зависит от исходного функционального состояния зрительной системы // Российский офтальмологический журнал, 2016; 1: 48-55.</p></abstract><trans-abstract xml:lang="en"><p>The paper’s objective was to determine the nature of changes in the bioelectric activity of the retina and the visual cortex in conditions of long-term staying of man in an enclosed space with artificial light generated by light-emitting diode (LED) lamps with variable spectral and power characteristics. In addition to a set of standard ophthalmic examinations, we recorded electroretinograms (ERG) to diffuse flashes, pattern-reversing and multifocal stimuli, and visual evoked cortical potentials (VEP) using the diagnostic system RETIport/scan21. The examinations were carried out in four healthy volunteers before and after an 11-day hermetic-chamber experiment simulating conditions of the spacecraft. Prolonged exposure to closed LED lighting created by sources with a high correlated color temperature (CCT), was shown to have no pronounced negative impact on the function of the retina. Changes in the amplitude of the ERG and VEP were minor, but displayed certain features specified by the history of previous injuries or functional disorders. Also, according to VEP waveforms to reversing checkerboard pattern, a characteristic sign of changes in the activity of the visual system in all participants was a splitting of the P100 peak, possibly related to temporal uncoupling of the activity of various visual channels. Thus, artificial LED lighting with high CCT can have both positive and adverse effects on the functional activity of the retina and the visual cortex, the nature of which, apparently, depends on the initial functional state of the visual system // Russian Ophthalmological Journal, 2016; 1: 48-55.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>искусственное освещение</kwd><kwd>светодиодные светильники</kwd><kwd>электрофизиологические исследования</kwd><kwd>сетчатка</kwd><kwd>зрительная кора</kwd><kwd>artificial lighting</kwd><kwd>LED light sources</kwd><kwd>electrophysiological studies</kwd><kwd>retina</kwd><kwd>visual cortex</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Островский М.А. Молекулярные механизмы повреждающего действия света на структуры глаза и системы защиты от такого повреждения. Успехи биологической химии. 2005; 45: 173-204.</mixed-citation><mixed-citation xml:lang="en">Островский М.А. Молекулярные механизмы повреждающего действия света на структуры глаза и системы защиты от такого повреждения. Успехи биологической химии. 2005; 45: 173-204.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Brainard G.C., Hanifin J.P., Greeson J.M., et al. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J. Neurosci. 2001; 21(16): 6405-12.</mixed-citation><mixed-citation xml:lang="en">Brainard G.C., Hanifin J.P., Greeson J.M., et al. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J. Neurosci. 2001; 21(16): 6405-12.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Arnault E., Barrau C., Nanteau C., et al. Phototoxic action spectrum on a retinal pigment epithelium model of age-related macular degeneration exposed to sunlight normalized conditions. PLoS ONE. 2013; 8(8): e71398.</mixed-citation><mixed-citation xml:lang="en">Arnault E., Barrau C., Nanteau C., et al. Phototoxic action spectrum on a retinal pigment epithelium model of age-related macular degeneration exposed to sunlight normalized conditions. PLoS ONE. 2013; 8(8): e71398.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hood D.C., Bach M., Brigell M., et al. ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc. Ophthalmol. 2012; 124: 1-13.</mixed-citation><mixed-citation xml:lang="en">Hood D.C., Bach M., Brigell M., et al. ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc. Ophthalmol. 2012; 124: 1-13.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">McCulloch D.L., Marmor M.F., Brigell M.G., et al. ISCEV Standard for full-field clinical electroretinography (2015 update). Doc. Ophthalmol. 2015; 130: 1-12.</mixed-citation><mixed-citation xml:lang="en">McCulloch D.L., Marmor M.F., Brigell M.G., et al. ISCEV Standard for full-field clinical electroretinography (2015 update). Doc. Ophthalmol. 2015; 130: 1-12.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bach M., Brigell M.G., Hawlina M., et al. ISCEV standard for clinical pattern electroretinography (PERG) - 2012 update. Doc. Ophthalmol. 2013; 124: 1-13.</mixed-citation><mixed-citation xml:lang="en">Bach M., Brigell M.G., Hawlina M., et al. ISCEV standard for clinical pattern electroretinography (PERG) - 2012 update. Doc. Ophthalmol. 2013; 124: 1-13.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Odom J.V., Bach M., Brigell M., et al. ISCEV standard for clinical visual evoked potentials (2009 update). Doc. Ophthalmol. 2010; 120: 111-9.</mixed-citation><mixed-citation xml:lang="en">Odom J.V., Bach M., Brigell M., et al. ISCEV standard for clinical visual evoked potentials (2009 update). Doc. Ophthalmol. 2010; 120: 111-9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Chiappa K.H., Jayakar J. Evoked potentials in clinical medicine. In: Baker A.B., Baker L.H., eds. Clinical neurology. New York, NY; Harper&amp;Row, 1989; 7: 148.</mixed-citation><mixed-citation xml:lang="en">Chiappa K.H., Jayakar J. Evoked potentials in clinical medicine. In: Baker A.B., Baker L.H., eds. Clinical neurology. New York, NY; Harper&amp;Row, 1989; 7: 148.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Misra U.K., Kalita J., eds. Visual Evoked Potential, Clinical Neurophysiology. Churchill Livingstone, New Delhi. 2011; 309-27.</mixed-citation><mixed-citation xml:lang="en">Misra U.K., Kalita J., eds. Visual Evoked Potential, Clinical Neurophysiology. Churchill Livingstone, New Delhi. 2011; 309-27.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Blumhardt L.D. Visual field defects and pathological alterations in topography: factors complicating the estimation of visual evoked response “delay” in multiple sclerosis. In: Cracco R.Q., Bodis-Wollner I., eds. Evoked Potentials. N.Y.: Alan R. Liss; 1986; 354-65.</mixed-citation><mixed-citation xml:lang="en">Blumhardt L.D. Visual field defects and pathological alterations in topography: factors complicating the estimation of visual evoked response “delay” in multiple sclerosis. In: Cracco R.Q., Bodis-Wollner I., eds. Evoked Potentials. N.Y.: Alan R. Liss; 1986; 354-65.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bynke H., Olsson J.E., Rosen I. Diagnostic value of visual evoked responses, clinical eye examination and CSF analysis in chronic myelopathy. Acta Neurol. Scand. 1977; 56: 55-69.</mixed-citation><mixed-citation xml:lang="en">Bynke H., Olsson J.E., Rosen I. Diagnostic value of visual evoked responses, clinical eye examination and CSF analysis in chronic myelopathy. Acta Neurol. Scand. 1977; 56: 55-69.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hoepper T., Lolas F. Visual evoked responses and visual symptoms in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1978; 41: 493-8.</mixed-citation><mixed-citation xml:lang="en">Hoepper T., Lolas F. Visual evoked responses and visual symptoms in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1978; 41: 493-8.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Carrol W.M., Halliday A.M., Kriss A. Improvement in the accuracy of pattern visual evoked potentials in the diagnosis of visual pathway disease. Neuroophthalmology. 1982; 2: 237-53.</mixed-citation><mixed-citation xml:lang="en">Carrol W.M., Halliday A.M., Kriss A. Improvement in the accuracy of pattern visual evoked potentials in the diagnosis of visual pathway disease. Neuroophthalmology. 1982; 2: 237-53.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mortimer M.J., Good P.A., Marsters J.B., Addy D.P. Visual evoked responses in children with migraine: a diagnostic test. Lancet. 1990; 335: 75-7.</mixed-citation><mixed-citation xml:lang="en">Mortimer M.J., Good P.A., Marsters J.B., Addy D.P. Visual evoked responses in children with migraine: a diagnostic test. Lancet. 1990; 335: 75-7.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sannita W.G., Lopez L., Piras C., Di Bon G. Scalprecorded oscillatory potentials evoked by transient pattern-reversal stimulation in man. Electroenceph. Clin. Neurophysiol. 1995; 96: 206-18.</mixed-citation><mixed-citation xml:lang="en">Sannita W.G., Lopez L., Piras C., Di Bon G. Scalprecorded oscillatory potentials evoked by transient pattern-reversal stimulation in man. Electroenceph. Clin. Neurophysiol. 1995; 96: 206-18.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kothari R., Singh R., Singh S., Bokariya P. Occurrence of “W” pattern in visual evoked potentials of primary open angle glaucomatous patients. Curr. Neurobiol. 2012; 3: 123-8.</mixed-citation><mixed-citation xml:lang="en">Kothari R., Singh R., Singh S., Bokariya P. Occurrence of “W” pattern in visual evoked potentials of primary open angle glaucomatous patients. Curr. Neurobiol. 2012; 3: 123-8.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Narici L., Carozzo S., Lopez L., Ogliastro C., Sannita W.G. Phaselocked oscillatory 15-30 Hz response to transient visual contrast stimulation: neuromagnetic evidence for cortical origin in humans. Neuroimage. 2003; 19: 950-58.</mixed-citation><mixed-citation xml:lang="en">Narici L., Carozzo S., Lopez L., Ogliastro C., Sannita W.G. Phaselocked oscillatory 15-30 Hz response to transient visual contrast stimulation: neuromagnetic evidence for cortical origin in humans. Neuroimage. 2003; 19: 950-58.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sannita W.G. Oscillatory responses and gamma activity. In: Celesia G.G., ed. Disorders of visual processing. Handbook of clinical neurophysiology. Elsevier Publishing Company; 2005.</mixed-citation><mixed-citation xml:lang="en">Sannita W.G. Oscillatory responses and gamma activity. In: Celesia G.G., ed. Disorders of visual processing. Handbook of clinical neurophysiology. Elsevier Publishing Company; 2005.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sannita W.G. Stimulus-specific oscillatory responses of the brain: a time/frequency-related coding process (review). Clin. Neurophysiol. 2000; 111: 565-83.</mixed-citation><mixed-citation xml:lang="en">Sannita W.G. Stimulus-specific oscillatory responses of the brain: a time/frequency-related coding process (review). Clin. Neurophysiol. 2000; 111: 565-83.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Sannita W.G., Carozzo S., Fioretto M., Garbarino S., Martinoli C. Abnormal waveform of the human pattern VEP: contribution from gamma oscillatory components. Invest. Ophthalmol. Vis. Sci. 2007; 48(10): 4534-41.</mixed-citation><mixed-citation xml:lang="en">Sannita W.G., Carozzo S., Fioretto M., Garbarino S., Martinoli C. Abnormal waveform of the human pattern VEP: contribution from gamma oscillatory components. Invest. Ophthalmol. Vis. Sci. 2007; 48(10): 4534-41.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Maunsell J.H.R. Functional visual streams. Curr. Opin. Neurobiol. 1992; 2: 506-10.</mixed-citation><mixed-citation xml:lang="en">Maunsell J.H.R. Functional visual streams. Curr. Opin. Neurobiol. 1992; 2: 506-10.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Vandewalle G., Gais S., Schabus M., et al. Wavelength-dependent modulation of brain responses to a working memory task by daytime light exposure. Cereb. Cortex. 2007; 17: 2788-95.</mixed-citation><mixed-citation xml:lang="en">Vandewalle G., Gais S., Schabus M., et al. Wavelength-dependent modulation of brain responses to a working memory task by daytime light exposure. Cereb. Cortex. 2007; 17: 2788-95.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Vandewalle G., Schmidt C., Albouy G., et al. Brain responses to violet, blue, and green monochromatic light exposures in humans: prominent role of blue light and the brainstem. PLoS ONE. 2007; 2:e1247.</mixed-citation><mixed-citation xml:lang="en">Vandewalle G., Schmidt C., Albouy G., et al. Brain responses to violet, blue, and green monochromatic light exposures in humans: prominent role of blue light and the brainstem. PLoS ONE. 2007; 2:e1247.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J. Photochem. Photobiol. B. 1999; 49: 1-17.</mixed-citation><mixed-citation xml:lang="en">Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J. Photochem. Photobiol. B. 1999; 49: 1-17.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Karu T.I., Kolyakov S.F. Exact action spectra for cellular responses relevant to phototherapy. Photomed. Laser Surg. 2005; 23(4): 355-61.</mixed-citation><mixed-citation xml:lang="en">Karu T.I., Kolyakov S.F. Exact action spectra for cellular responses relevant to phototherapy. Photomed. Laser Surg. 2005; 23(4): 355-61.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sutherland J.C. Biological effects of polychromatic light. Photochem. Photobiol. 2002; 76: 164-70.</mixed-citation><mixed-citation xml:lang="en">Sutherland J.C. Biological effects of polychromatic light. Photochem. Photobiol. 2002; 76: 164-70.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Whelan H.T., Wong-Riley M.T.T., Eells J.T., et al. DARPA Soldier Self Care: Rapid Healing of Laser Eye Injuries with Light Emitting Diode Technology. In: The RTO HFM Symposium on “Combat Casualty Care in Ground Based Tactical Situations: Trauma Technology and Emergency Medical Procedures”. St. Pete Beach, USA, 2004; RTO-MP-HFM-109: P19-1 - P19-18.</mixed-citation><mixed-citation xml:lang="en">Whelan H.T., Wong-Riley M.T.T., Eells J.T., et al. DARPA Soldier Self Care: Rapid Healing of Laser Eye Injuries with Light Emitting Diode Technology. In: The RTO HFM Symposium on “Combat Casualty Care in Ground Based Tactical Situations: Trauma Technology and Emergency Medical Procedures”. St. Pete Beach, USA, 2004; RTO-MP-HFM-109: P19-1 - P19-18.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Albarracin R., Eells J., Valter K. Photobiomodulation Protects the Retina from Light-Induced Photoreceptor Degeneration. Invest Ophthalmol Vis Sci. 2011; 52: 3582-92.</mixed-citation><mixed-citation xml:lang="en">Albarracin R., Eells J., Valter K. Photobiomodulation Protects the Retina from Light-Induced Photoreceptor Degeneration. Invest Ophthalmol Vis Sci. 2011; 52: 3582-92.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Зуева M.В., Иванина Т.А. Повреждающее действие видимого света на сетчатку в эксперименте (электрофизиологические и электронно-микроскопические исследования). Вестник офтальмологии. 1980; 4: 48-51.</mixed-citation><mixed-citation xml:lang="en">Зуева M.В., Иванина Т.А. Повреждающее действие видимого света на сетчатку в эксперименте (электрофизиологические и электронно-микроскопические исследования). Вестник офтальмологии. 1980; 4: 48-51.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Аладов А.В., Закгейм А.Л., Мизеров М.Н., Черняков А.Е. О биологическом эквиваленте излучения светодиодных и традиционных источников света с цветовой температурой 1800-10000 K. Светотехника. 2012; 3: 7-10.</mixed-citation><mixed-citation xml:lang="en">Аладов А.В., Закгейм А.Л., Мизеров М.Н., Черняков А.Е. О биологическом эквиваленте излучения светодиодных и традиционных источников света с цветовой температурой 1800-10000 K. Светотехника. 2012; 3: 7-10.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Корсакова Е.А., Слезин В.Б., Шульц Е.В. и др. Воздействие белого света с варьируемой цветовой температурой на электроэнцефалограмму человека. Вестник новых медицинских технологий. 2012; 9(4): 30-3.</mixed-citation><mixed-citation xml:lang="en">Корсакова Е.А., Слезин В.Б., Шульц Е.В. и др. Воздействие белого света с варьируемой цветовой температурой на электроэнцефалограмму человека. Вестник новых медицинских технологий. 2012; 9(4): 30-3.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">CEI/IEC 62471/2006. Photobiological safety of lamps and lamp systems. International Standard. 2006.</mixed-citation><mixed-citation xml:lang="en">CEI/IEC 62471/2006. Photobiological safety of lamps and lamp systems. International Standard. 2006.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Dorfman A.L., Joly S., Hardy P., Chemtob S., Lachapelle P. The effect of oxygen and light on the structure and function of the neonatal rat retina. Doc. Ophthalmol. 2009; 118: 37-54.</mixed-citation><mixed-citation xml:lang="en">Dorfman A.L., Joly S., Hardy P., Chemtob S., Lachapelle P. The effect of oxygen and light on the structure and function of the neonatal rat retina. Doc. Ophthalmol. 2009; 118: 37-54.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Huang Y.Y., Chen A.C., Carroll J.D., Hamblin M.R. Biphasic dose response in low level light therapy. Dose Response. 2009; 7(4): 358-83.</mixed-citation><mixed-citation xml:lang="en">Huang Y.Y., Chen A.C., Carroll J.D., Hamblin M.R. Biphasic dose response in low level light therapy. Dose Response. 2009; 7(4): 358-83.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Mather L. FDA approves LED light therapy device from BioPhotas. Available at http://www.bioopticsworld.com/articles/2013/01/fda-approves-led-light-therapy-device-from-biophotas.html</mixed-citation><mixed-citation xml:lang="en">Mather L. FDA approves LED light therapy device from BioPhotas. Available at http://www.bioopticsworld.com/articles/2013/01/fda-approves-led-light-therapy-device-from-biophotas.html</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">SCENIHR (Scientific Committee on Emerging and Newly Identified Health Risks). «Health Effects of Artificial Light». 2013. Available at http://ec.europa.eu/health/scientific_committees/ emerging/docs/scenihr_o_033.pdf</mixed-citation><mixed-citation xml:lang="en">SCENIHR (Scientific Committee on Emerging and Newly Identified Health Risks). «Health Effects of Artificial Light». 2013. Available at http://ec.europa.eu/health/scientific_committees/ emerging/docs/scenihr_o_033.pdf</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Зак П.П., Островский М.А. Потенциальная опасность освещения светодиодами для глаз детей и подростков. Светотехника. 2012; 3: 39-42. Zakh P.P., Ostrovsky M.A. The potential danger of LED lighting for the eyes of children and adolescents. Svetotehnika. 2012; 3: 39-42 (in Russian).</mixed-citation><mixed-citation xml:lang="en">Зак П.П., Островский М.А. Потенциальная опасность освещения светодиодами для глаз детей и подростков. Светотехника. 2012; 3: 39-42. Zakh P.P., Ostrovsky M.A. The potential danger of LED lighting for the eyes of children and adolescents. Svetotehnika. 2012; 3: 39-42 (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ham W.T., Mueller H.A., Sliney D.H. Retinal sensitivity to damage from short wavelength light. Nature. 1976; 260(5547): 153-5.</mixed-citation><mixed-citation xml:lang="en">Ham W.T., Mueller H.A., Sliney D.H. Retinal sensitivity to damage from short wavelength light. Nature. 1976; 260(5547): 153-5.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Kitchel E. The Effects of Blue Light on Ocular Health. J. Vis. Impair. Blind. 2000; 94(6): 357-61.</mixed-citation><mixed-citation xml:lang="en">Kitchel E. The Effects of Blue Light on Ocular Health. J. Vis. Impair. Blind. 2000; 94(6): 357-61.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Роспотребнадзор. Об организации санитарного надзора за ис- пользованием энергосберегающих источников света. Письмо № 01/11157-32 от 01.10.2012.</mixed-citation><mixed-citation xml:lang="en">Роспотребнадзор. Об организации санитарного надзора за ис- пользованием энергосберегающих источников света. Письмо № 01/11157-32 от 01.10.2012.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
