Preview

Russian Ophthalmological Journal

Advanced search

Criteria for choosing the energy of micropulse transscleral cyclophotocoagulation

https://doi.org/10.21516/2072-0076-2023-16-4-18-23

Abstract

For a long time, the main parameter of micropulse cyclophotocoagulation (mTS-CPC) operation planning has been the calculated total energy. However, this indicator alone is not enough to determine more accurate correlations between exposure parameters and treatment outcomes.

Purpose: to determine the criteria for choosing energy parameters to be used in mTS-CPC in refractory glaucoma patients.

Material and methods. We propose a more reliable indicator of mTS-CPC clinical results, the energy flow, which is calculated from the speed of the probe movement. We developed and used a new strategy for conducting mTS-CPC: dividing the hemispheres of the ocular surface into 4 quadrants for a better control of the light guide movement while maintaining the selected speed. The standardized protocol for conducting the procedure has been modified so that the calculated energy flow is 121.8 J/cm2.

Results. The evaluation of the treatment results of 140 patients according to the Kaplan Meier criteria showed the success of the treatment. IOP fell by 30 %, as compared with the baseline in the advanced stage, and by 20 % in the terminal stage, causing no complications. 12 months after the follow-up start, IOP compensation was noted in 81.3 % of cases.

Conclusion. The presented modification of mTS-CPC using the energy flow parameters makes it possible to unify the technology of laser treatment, and the results obtained demonstrate a good and uncomplicated hypotensive effect. The availability of standardized energy indicators allows for a selective treatment tactics, depending on the individual characteristics of glaucomatous patients.

About the Authors

I. E. Ioshin
Clinical Hospital
Russian Federation

Igor E. Ioshin — Dr. of Med. Sci., professor, head of the ophthalmological center

45, Losinoostrovskaya St., Moscow, 107143, Russia



A. I. Tolchinskaya
Clinical Hospital
Russian Federation

Anna I. Tolchinskaya — Dr. of Med. Sci., ophthalmologist of the ophthalmological center

45, Losinoostrovskaya St., Moscow, 107143, Russia



I. V. Maksimov
Clinical Hospital
Russian Federation

Ivan V. Maksimov — ophthalmologist of the ophthalmological center

45, Losinoostrovskaya St., Moscow, 107143, Russia



References

1. Tan AM, Chockalingam M, Aquino MC, et al. Micropulse transscleral diode laser cyclophotocoagulation in the treatment of refractory glaucoma. Clin Experiment Ophthalmol. 2010; 38 (3): 266–72. doi: 10.1111/j.1442-9071.2010.02238.x

2. Al Habash A, AlAhmadi AS. Outcome of MicroPulse(®) transscleral photocoagulation in different types of glaucoma. Clin Ophthalmol Auckl NZ. 2019; 13: 2353–60. doi: 10.2147/OPTH.S226554

3. Nguyen AT, Maslin J, Noecker RJ. Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma. Eur J Ophthalmol. 2020; 30 (4): 700–5. doi: 10.1177/112067211 9839303

4. Sarrafpour S, Saleh D, Ayoub S, et al. Micropulse transscleral cyclophotocoagulation: a look at long-term effectiveness and outcomes. Ophthalmol Glaucoma. 2019; 2 (3): 167–71. doi: 10.1016/j. ogla.2019.02.002

5. Keilani C, Benhatchi N, Bensmail D, et al. Comparative effectiveness and tolerance of subliminal subthreshold transscleral cyclophotocoagulation with a duty factor of 25 % versus 31.3 % for advanced glaucoma. J Glaucoma. 2020; 29 (2): 97–103. doi: 10.1097/ IJG.0000000000001409

6. Grippo TM, Sanchez FG, Stauffer J, Marcellino G. MicroPulse® Transscleral Laser Therapy — fluence may explain variability in clinical outcomes: A literature review and analysis. Clinical ophthalmology (Auckland, N.Z.). 2021; 15: 2411–9. doi: 10.2147/OPTH.S313875

7. Johnstone M, Murray J. Transcleral Laser Induces Aqueous Outflow Pathway Motion & Reorganization. AGS 2017; Coronado, CA2017. https://www.iridex.com/portals/0/pdf/Transcleral-induces-aqueous-outflow-pathway-motionand-reorganization-Dr.pdf

8. Sanchez FG, Lerner F, Sampaolesi J, et al. Efficacy and safety of Micropulse® transscleral cyclophotocoagulation in glaucoma. Arch Soc Espanola Oftalmol. 2018; 93 (12): 573–9. doi: 10.1016/j. oftal.2018.08.003

9. Aquino MCD, Barton K, Tan AM, et al. Micropulse versus continuous wave transscleral diode cyclophotocoagulation in refractory glaucoma: a randomized exploratory study. Clin Experiment Ophthalmol. 2015; 43 (1): 40–6. doi: 10.1111/ceo.12360

10. Lee JH, Shi Y, Amoozgar B, et al. Outcome of Micropulse laser transscleral cyclophotocoagulation on pediatric versus adult glaucoma patients. J Glaucoma. 2017; 26 (10): 936–9. doi: 10.1097/ IJG.0000000000000757

11. Sanchez FG, Peirano-Bonomi JC, Grippo TM. Micropulse transscleral cyclophotocoagulation: A hypothesis for the ideal parameters. Med Hypothesis Discov Innov Ophthalmol. 2018, Fall; 7 (3): 94–100. PMID: 30386797

12. Souissi S, Baudouin C, Labbé A, et al. Micropulse transscleral cyclophotocoagulation using a standard protocol in patients with refractory glaucoma naive of cyclodestruction. Eur J Ophthalmol. 2019; 31 (1): 112–9. doi: 10.1177/1120672119877586

13. Barac R, Vuzitas M, Balta F. Choroidal thickness increase after micropulse transscleral cyclophotocoagulation. Romanian J Ophthalmol. 2018; 62 (2): 144–8. doi: 10.22336/rjo.2018.21

14. Magacho L, Lima FE, Ávila MP. Double-session micropulse transscleral laser (CYCLO G6) for the treatment of glaucoma. Lasers Med Sci. 2020 Sep; 35 (7): 1469–75. doi: 10.1007/s10103-019-02922-1

15. Preda MA, Karancsi OL, Munteanu M, Stanca HT. Clinical outcomes of micropulse transscleral cyclophotocoagulation in refractory glaucoma-18 months follow-up. Lasers Med Sci. 2020 Sep; 35 (7): 1487–91. doi: 10.1007/s10103-019-02934-x

16. Subramaniam K, Price MO, Feng MT, et al. Micropulse transscleral cyclophotocoagulation in keratoplasty eyes. Cornea. 2019; 38 (5): 542–5. doi: 10.1097/ICO.0000000000001897

17. Yelenskiy A, Gillette TB, Arosemena A, et al. Patient outcomes following micropulse transscleral cyclophotocoagulation: intermediate-term results. J Glaucoma. 2018; 27 (10): 920–5. doi: 10.1097/IJG.0000000000001023

18. Zaarour K, Abdelmassih Y, Arej N, et al. Outcomes of micropulse transscleral cyclophotocoagulation in uncontrolled glaucoma patients. J Glaucoma. 2019; 28 (3): 270–5. doi: 10.1097/ IJG.0000000000001174

19. Magacho L, Lima FE, Ávila MP. Double-session micropulse transscleral laser (CYCLO G6) as a primary surgical procedure for glaucoma. J Glaucoma 2020; 29 (3): 205–10. doi: 10.1097/IJG.00000000 00001426

20. Emanuel ME, Grover DS, Fellman RL, et al. Micropulse cyclophotocoagulation: initial results in refractory glaucoma. J Glaucoma. 2017; 26 (8): 726–9. doi: 10.1097/IJG.00000000 00000715

21. Williams AL, Moster MR, Rahmatnejad K, et al. Clinical efficacy and safety profile of Micropulse transscleral cyclophotocoagulation in refractory glaucoma. J Glaucoma. 2018; 27 (5): 445–9. doi: 10.1097/IJG.0000000000000934

22. de Crom R, Slangen C, Kujovic-Aleksov, et al. Micropulse trans-scleral cyclophotocoagulation in patients with glaucoma: 1- and 2-year treatment outcomes. Journal of glaucoma. 2020; 29 (9): 794–8. doi: 10.1097/IJG.0000000000001552

23. Varikuti VNV, Shah P, Rai O, et al. Outcomes of micropulse transcleral cyclophotocoagulation in eyes with good central vision. J Glaucoma. 2019; 28 (10): 901–5. doi: 10.1097/IJG. 0000000000001339

24. Garcia GA, Nguyen CV, Yelenskiy A, et al. Micropulse transscleral diode laser cyclophotocoagulation in refractory glaucoma: Short-term efficacy, safety, and impact of surgical history on outcomes. Ophthalmol Glaucoma. 2019 Nov-Dec; 2 (6): 402–12. doi: 10.1016/j.ogla.2019.08.009

25. Ioshin I.E., Tolchinskaya A.I., Maksimov I.V., Rakova A.V. Method of micropulse transscleral cyclophotocoagulation for refractory glaucoma. Patent for invention No. 2780277 dated December 17, 2021 (In Russ.).

26. IRIDEX. Available from: https://www.iridex.com/Products/GlaucomaDevices/micropulsep3.aspx. Accessed may 30, 2022.

27. Grippo TM, de Crom RMPC, Giovingo M, et al. Evidence-Based consensus guidelines series for micropulse transscleral laser therapy: Dosimetry and patient selection. Clin Ophthalmol. 2022 Jun 7; 16: 1837–46. doi: 10.2147/OPTH.S365647


Review

For citations:


Ioshin I.E., Tolchinskaya A.I., Maksimov I.V. Criteria for choosing the energy of micropulse transscleral cyclophotocoagulation. Russian Ophthalmological Journal. 2023;16(4):18-23. (In Russ.) https://doi.org/10.21516/2072-0076-2023-16-4-18-23

Views: 250


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-0076 (Print)
ISSN 2587-5760 (Online)