Eye damage in a patient with syphilis/HIV coinfection. A clinical case
https://doi.org/10.21516/2072-0076-2023-16-4-133-140
Abstract
In recent years, the literature has been discussing the issues of diagnosis and managing damaged eye patients who suffer from syphilis/HIV coinfection. We present a clinical case of syphilitic uveitis in the patient’s third reinfection of syphilis, which occurred during a long-term HIV infection. The causes for insufficient treatment effectiveness are analyzed.
About the Authors
O. K. Loseva
Russian Biotechnological University (ROSBIOTECH); Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology
Russian Federation
Russian Federation
Olga K. Loseva — Dr. of Med. Sci., professor1, dermatovenereologist
11, Volokolamsk Hgwy, Moscow, 125080, Russia
17, Leninsky Prospect, Moscow, 119071, Russia
R. G. Tuaeva
Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology
Russian Federation
Russian Federation
Renata G. Tuaeva — dermatovenereologist
17, Leninsky Prospect, Moscow, 119071, Russia
O. V. Zhukova
Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology
Russian Federation
Russian Federation
Olga V. Zhukova — Dr. of Med. Sci., professor, chief medical officer
17, Leninsky Prospect, Moscow, 119071, Russia
T. P. Bessarab
Moscow City Center for the Prevention and Control of AIDS
Russian Federation
Russian Federation
Timur P. Bessarab — Cand. of Med. Sci., head of department of the prevention of AIDS
15, Bldg. 5, 8th Sokolinyaya Gora St., Moscow, 105275, Russia
E. A. Kleshcheva
Russian Medical Academy of Continuous Professional Education; S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
Elena A. Klescheva — Cand. of Med. Sci., associate professor department of ophthalmology; ophthalmologist5
2/1, Barrikadnaya St., Moscow, 125993, Russia
5, 2nd Botkinsky Drive., Moscow, 125284, Russia
G. Sh. Safina
S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
Gul'nara Sh. Safina — ophthalmologist
5, 2nd Botkinsky Drive., Moscow, 125284, Russia
References
1. Okhotsimskaya S.A., Sogreeva E.N., Lavrov A.Yu., Taktamysheva E.Sh. Syphilitic uveitis. Vestnik oftalmologii. 1998; 114 (3): 52–4 (In Russ.).
2. Dutta Majumder P, Chen EJ, Shah J, et al. Ocular Syphilis: An Update. Ocul Immunol Inflamm. 2019; 27 (1): 117–25. https://doi.org/10.1080/09273948.2017.1371765
3. Oliver S, Sahi Sh, Tantalo BS. Molecular typing of Treponema pallidum in ocular syphilis. Sex Trans. Dis. 2016; 8 (43): 524–7. https://doi.org/10.1097/OLQ.0000000000000478
4. Parc CE, Chahed S, Patel SV, Salmon-Ceron D. Manifestations and treatment of ocular syphilis during an epidemic in France. Sex. Transm. Dis. 2007; 34 (8): 553–6. https://doi.org/10.1097/01.olq.0000253385.49373.1a
5. Wons J, Kempen J, Garweg JG. HIV-induced retinitis. Ocul Immunol Inflamm. 2020; 28 (8): 1259–68. https://doi.org/10.1080/09273948.2020.1808225
6. Orlova I.A., Telichko S.I., Smirnova I.О., et al. Diagnostic significance of otorhinolaryngological and ophthalmic pathology in patients suffering from neurosyphilis infected with human immunodeficiency virus. Bulletin of the Russian Military Medical Academy. 2020; 2 (70): 23–6 (In Russ.). https://doi.org/10.17816/brmma50040
7. Balba GP, Kumar PN, James AN, et al. Ocular syphilis in HIV-positive patients receiving highly active antiretroviral therapy. Am J Med. 2006; 119 (5): 448. e21–448.e25. https://doi.org/10.1016/j.amjmed.2005.11.016
8. Browning DJ. Posterior segment manifestations of active ocular syphilis, their response to a neurosyphilis regimen of penicillin therapy, and the influence of human immunodeficiency virus status on response. Ophthalmology. 2000; 107 (11): 2015–23. https://doi.org/10.1016/s0161-6420(00)00457-7
9. McLeish WM, Pulido JS, Holland S, Gulbertson WW, Winward K. The ocular manifestations of syphilis in the human immunodeficiency virus type 1-infected host. Ophthalmology. 1990; 97 (2): 196–203. https://doi.org/10.1016/s0161-6420(90)32605-2
10. Thami GP, Kaur S, Gupta R, Kanwar AJ, Sood S. Syphilitic panuveitis and asymptomatic neurosyphilis: a marker of HIV-infection. Int J STD AIDS. 2001; 12 (11): 754–6. https://doi.org/10.1258/0956462011924146
11. Krasnoselskikh T.V., Manasheva E.B., Gezei M.A., et al. Neurosyphilis in patients with HIV infection: difficulties in diagnostics. Klinicheskaya dermatologiya i venerologiya. 2019; 18 (1): 64–70 (In Russ.). https://doi.org/10.17116/klinderma20191801164
12. Torshina I.E., Mogilevtsev V.V., Lugovaya A.A. On a problem of syphilitic damage of the eye. Vestnik oftal'mologii. 2011; 127 (1): 52–6 (In Russ.).
13. Krasnoselskikh T.V., Sokolovskiy E.V. Current standards for diagnosis of syphilis: comparing the russian and foreign guidelines (part I). Vestnik dermatologii i venerologii. 2015; 91 (2): 11–22 (In Russ.). https://doi.org/10.25208/0042-4609-2015-91-2-11-22
14. Al Hanaineh AT, Hassanein DH, Abdelbaky SH, El Zawahry OM. Steroidinduced ocular hypertension in the pediatric age group. Eur J Ophthalmol. 2018; 28 (4): 372–7. https://doi.org/10.1177/1120672118757434
15. Taniguchi J, Sharma A. Fluorometholone modulates gene expression of ocular surface mucins. Acta Ophthalmol. 2019; 97 (8): e1082–e1088. https://doi.org/10.1111/aos.14113
16. Saade JS, Istambouli R, AbdulAal M, Antonios R, Hamam RN. Bromfenac 0.09% for the treatment of macular edema secondary to noninfectious uveitis. Middle East Afr J Ophthalmol. 2021; 25; 28 (2): 98–103. https://doi.org/10.4103/meajo.meajo_134_21
17. Sventitskaya A.L., Veselova E.I., Kaminskii G.D. Immune reconstitution inflammatory syndrome in persons with hiv: searching for biomarkers for prognosis, prevention, and treatment. Lechebnoe delo. 2022; (3–4): 103–6 (In Russ.). https://doi.org/10.24412/2071-5315-2022-12924
Review
For citations:
Loseva O.K., Tuaeva R.G., Zhukova O.V., Bessarab T.P., Kleshcheva E.A., Safina G.Sh. Eye damage in a patient with syphilis/HIV coinfection. A clinical case. Russian Ophthalmological Journal. 2023;16(4):133-140. (In Russ.) https://doi.org/10.21516/2072-0076-2023-16-4-133-140
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