Role of densitometry and combination therapy in ultrasound-free femtosecond laser lens surgery in patients with refractive disorders

Purpose the study — to evaluate the effectiveness of a personalized approach to femtosecond laser fragmentation of the lens nucleus based on densitometry, as well as to analyze the effect of a combination drug (ketorolac + levofloxacin) on perioperative patient management. Material and methods. The study included 64 patients (64 eyes) aged 52 ± 10 with ametropia of various degrees and types, as well as with cataracts of I–III degrees of lens nucleus density according to the PNS and Buratto classification. Preoperative densitometry was performed on Pentacam and Galilei G6. The data were used for personalized selection of femtosecond laser energy and nuclear fragmentation pattern. Patients of group 1 (n = 33) received a combination drug (non-steroidal anti-inflammatory drug (NSAID) and antibiotic), in group 2 (n = 31) — NSAID and antibiotic separately. Results. Personalized femtolaser parameters provided effective fragmentation of the nucleus in all cases. Combined therapy showed advantages over separate therapy in terms of mydriasis stability, inflammation prevention, and treatment adherence. Conclusion. The study confirms the importance of densitometric assessment of lens density and combined drug therapy to improve the efficacy and safety of femtolaser-assisted refractive lens surgery.

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