Effect of cycloplegia on keratometric and biometric parameters in keratoconus and controls
https://doi.org/10.21516/2072-0076-2025-18-4-68-73
Abstract
Purpose. This study aimed to evaluate and compare the effect of cycloplegia on keratometric and biometric parameters in keratoconus patients and controls.
Materials and methods. A preand post-interventional study was performed on 48 keratoconus (KC) patients diagnosed per Collaborative Longitudinal Evaluation of Keratoconus (CLEK’s) Classification and 41 age-matched controls. Full ophthalmological evaluations included refractive, keratometric, and biometric measurements with an auto kerato-refractometer (Topcon KR-800) and IOL MASTER 700, using 1% cyclopentolate hydrochloride for cycloplegia.
Results. The study compared ocular measurements in KC patients and a control group before and after cycloplegia. KC patients exhibited significant changes in flat keratometry K1 (47.52 to 47.34), steep keratometry K2 (52.67 to 52.13), spherical equivalent (SE) (-6.35 to -5.5), lens thickness (LT) (3.49 to 3.44), anterior chamber depth (ACD) (3.75 to 3.84), and central corneal thickness (CCT) (446.78 to 450.72), all significant (p< 0.01), while axial length (AL) remained unchanged (23.5). The control group showed no significant differences in K1, K2, or AL, but SE, LT, ACD, and CCT exhibited significant changes.
Conclusion. KC patients have a greater susceptibility to changes in corneal parameters post-cycloplegia compared to controls. These findings highlight the importance of careful evaluation in KC patients due to their distinct ocular responses to cycloplegia.
About the Authors
F. Kanwal
Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital Rawalpindi
Pakistan
Pakistan
Faiza Kanwal — B.Sc. Honor Optometry and Orthoptics, Optometrist
Punjab 4600
I. Nasim
Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital Rawalpindi
Pakistan
Pakistan
Iffat Nasim — B.Sc. Honor Optometry and Orthoptics, Optometrist
Punjab 4600
R. Ali
Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital Rawalpindi
Pakistan
Pakistan
Raza Ali — FCPS, DOMS, MBBS, ophthalmologist
Punjab 4600
S. Ullah
Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital Rawalpindi
Pakistan
Pakistan
Saif Ullah — PHD scholar, Mphil Optometry, MPH, B.Sc., Honor Optometry and Orthoptics, Assistant Professor, Head of Department
Punjab 4600
S. Qayyum
Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital Rawalpindi
Pakistan
Pakistan
Sadaf Qayyum — PHD scholar, Mphil Optometry, B.Sc. Honor Optometry and Orthoptics, Senior Lecturer
Punjab 4600
R. Faheem
Pakistan Institute of Ophthalmology, Al-Shifa Trust Eye Hospital Rawalpindi
Pakistan
Pakistan
Rabia Faheem — B.Sc. Honor Optometry and Orthoptics, Optometrist
Punjab 4600
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Review
For citations:
Kanwal F., Nasim I., Ali R., Ullah S., Qayyum S., Faheem R. Effect of cycloplegia on keratometric and biometric parameters in keratoconus and controls. Russian Ophthalmological Journal. 2025;18(4):68-73. https://doi.org/10.21516/2072-0076-2025-18-4-68-73
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