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Molluscum contagiosum: a literature review and a clinical case of contagiosum localization on the conjunctiva

https://doi.org/10.21516/2072-0076-2026-19-3-107-110

Abstract

Molluscum contagiosum is a benign skin and mucous membrane disease caused by a virus of the Poxviridae family, prone to spontaneous regression at varying times after infection. This review examines the etiology, prevalence, routes of infection, lesion location, pathological presentation, and treatment methods for molluscum contagiosum. The article also presents a case of its extremely rare conjunctival localization.

About the Authors

A. F. Makhneva
National Research Center of Phthisiopulmonology
Kazakhstan

Anna F. Makhneva — Cand. of Med. Sci., pathologist.

1/1, Botakoz St., Almaty, 050014



D. B. Abdrakhimova
Kazakh Research Institute of Eye Diseases
Kazakhstan

Dariga B. Abdrakhimova — Dr. of Med. Sci., head of the laboratory of pathological research and tissue preservation.

95a, Tole Bi St., Almaty, 050012



A. N. Bekisheva
National Research Center of Phthisiopulmonology
Kazakhstan

Aigul N. Bekisheva — Cand. of Med. Sci., pathologist.

1/1, Botakoz St., Almaty, 050014



References

1. Bateman T. Delineations of Skin Diseases, London, 1817.

2. Paterson R. Cases and observations on the molluscum contagiosum of Bateman, with an account of the minute structure of the tumours. Edinb Med Surg J. 1841 Jul 1; 56 (148): 279–88. PMID: 30331147.

3. Juliusberg M. Zur Kenntnis des virus des Molluscum contagiosum. Dtsch Med Wochenschr. 1905; 31 (40): 1598–9. doi: 10.1055/s-0029-1188377

4. Yakobzon L.Ya. Brockhaus and Efron Encyclopedic Dictionary. V. 86 (82 t. and 4 dop.). SPb; 1890–1907 (In Russ.).

5. Korsunskaya I.M., Mazankova L.N., Tamrazova O.B. Viral dermatoses in children. Praktika pediatra. 2005 (September); 28–9 (In Russ.).

6. Leung AKC, Barankin B, Hon KLE. Molluscum Contagiosum: An update. Recent Pat Inflamm Allergy Drug Discov. 2017; 11 (1): 22–31. doi: 10.2174/1872213X11666170518114456

7. Talel Badri, Grishma R Gandhi. Molluscum Contagiosum. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Mar 27. https://www.ncbi.nlm.nih.gov/pubmed/28722927

8. Ruby KN, Perry AE, Linos K. Expanding the morphologic heterogeneity of stromal changes in Molluscum Contagiosum infection. Am J Dermatopathol. 2018 Dec; 40 (12): 941–3. doi: 10.1097/DAD.0000000000001015

9. Peterson AR, Nash E, Anderson BJ. Infectious disease in contact sports. Sports Health. 2019 Jan/Feb; 11 (1): 47–58. doi: 10.1177/1941738118789954

10. Rosner M, Zloto O. Periocular molluscum contagiosum: six different clinical presentations. Acta Ophthalmol. 2018 Aug; 96 (5): e600–e605. doi: 10.1111/aos.13717

11. Plotnikova Yu.A., Belykh L.V., Kudryavtseva Yu.V. A clinical case of corneal ulcer associated with viral eyelid infection in a patient in the post-COVID period. Vyatskiy meditsinskiy vestnik. 2024; 1 (81): 100–4 (In Russ.). doi: 10.24412/2220-7880-2024-1-100-104

12. Bhatia N, Hebert A, Del Rosso J. Comprehensive management of molluscum contagiosum: assessment of clinical associations, comorbidities, and management principles. J Clin Aesthet Dermatol. 2023 Aug; 16 (8 Suppl 1): S12-S17. PMID: 37636015.

13. Kaufman WS, Ahn CS, Huang WW. Molluscum contagiosum in immunocompromised patients: AIDS presenting as molluscum contagiosum in a patient with psoriasis on biologic therapy. Cutis. 2018 Feb; 101 (2): 136–40. PMID: 29554156.

14. Chaurasia S, Rastogi V, Maddheshiya N, Dhungel D, Ramalingam K. Eyelid Lesion of Molluscum contagiosum: A Case Report and Literature Review. Cureus. 2024 Jan 14; 16 (1): e52272. doi: 10.7759/cureus.52272

15. Pakhirko I.N., Konovalova N.A., Zdanovich V.V. A rare case of molluscum contagiosum of the conjunctiva of the eyeball. Tochka zreniya. Vostok — Zapad. 2015; 2: 62–3 (In Russ.).

16. Serin Ş, Ofl az AB, Karabağlı P, et al. Eyelid Molluscum Contagiosum lesions in two patients with unilateral chronic conjunctivitis. Turk J Ophthalmol. 2017 Aug; 47 (4): 226–30. doi: 10.4274/tjo.52138

17. Murray R. Conjunctival molluscum contagiosum. Eye. 2004; 18: 740. doi: 10.1038/sj.eye.6700741

18. Ringeisen AL, Raven ML, Barney NP. Bulbar conjunctival Molluscum Contagiosum. Ophthalmology. 2016 Feb; 123 (2): 294. doi: 10.1016/j.ophtha.2015.11.022

19. Murashkin N.N., Materikin A.I., Ambarchyan E.T., Epishev R.V. Molluscum Contagiosum in children: Peculiarities of course and modern approaches to therapy. Pediatricheskaya farmakologiya. 2016; 13 (6): 597–600 (In Russ.). doi: 10.15690/pf.v13i6.1675

20. Rayala BZ, Morrell DS. Common skin conditions in children: Skin infections. FP Essent. 2017 Feb; 453: 26–32. PMID: 28196318.

21. Federal Clinical Guidelines for the Management of Patients with Molluscum Contagiosum. Moscow-2015 (In Russ.). https://diseases.medelement.com/disease/контагиозныймоллюск-рекомендации-рф/15229

22. Van der Wouden JC, van der Sande R, Kruithof EJ, et al. Interventions for cutaneous molluscum contagiosum. Cochrane Database Syst Rev. 2017 May 17; 5 (5): CD004767.

23. Potekaev N.S., Potekaev S.N., Potekaev N.N., Zhukova O.V. Molluscum contagiosum in HIV-negative individuals and those suffering from HIV disease. Klinicheskaya dermatologiya i venerologiya. 2017; 16 (3): 103–9 (In Russ.). doi: 10.17116/klinderma2017163103-107

24. Konya J, Thompson CH. Molluscum contagiosum virus: antibody responses in persons with clinical lesions and seroepidemiology in a representative Australian population. J Infect Dis. 1999 Mar; 179 (3): 701–4. doi: 10.1086/314620

25. Konya J, Thompson CH, De Zwart-Steffe RT. Enzyme-linked immunosorbent assay for measurement of IgG antibody to molluscum contagiosum virus and investigation of the serological relationship of the molecular types. J Virol Methods. 1992 Nov; 40 (2): 183–94. doi: 10.1016/0166-0934(92)90067-n

26. Silverberg N. Pediatric molluscum: an update. Cutis. 2019 Nov; 104 (5): 301–5; E1; E2. PMID: 31886783.

27. Meza-Romero R, Navarrete-Dechent C, Downey C. Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment. Clin Cosmet Investig Dermatol. 2019 May 30; 12: 373–81. doi: 10.2147/CCID.S187224

28. Hanson D, Diven DG. Molluscum contagiosum. Dermatol Online J. 2003; 9: 2. https://doi.org/10.5070/D36z11d13p

29. Lacarrubba F, Verzì AE, Dinotta F, Scavo S, Micali G. Dermatoscopy in inflammatory and infectious skin disorders. G Ital Dermatol Venereol. 2015 Oct; 150 (5): 521–31. PMID: 26333553.

30. Gofur NRP, Gofur ARP, Soesilaningtyas, et al. Molluscum contagiosum diagnosis, manifestation and management: a review article. Jap J Clin & Med Res. 2022; 2: 1–3. doi: 10.47363/JJCMR/2022(2)12

31. Eichenfield L, Hebert A, Mancini A, Rosen T, Weiss J. Therapeutic approaches and special considerations for treating molluscum contagiosum. Drugs Dermatol. 2021; 20: 1185–90. doi: 10.36849/jdd.6383

32. De Clercq E. Cidofovir for the treatment of molluscum contagiosum virus. Viruses. 2022; 14 (11): 2484. doi: 10.3390/v14112484


Review

For citations:


Makhneva A.F., Abdrakhimova D.B., Bekisheva A.N. Molluscum contagiosum: a literature review and a clinical case of contagiosum localization on the conjunctiva. Russian Ophthalmological Journal. 2026;19(3):107-110. (In Russ.) https://doi.org/10.21516/2072-0076-2026-19-3-107-110

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ISSN 2072-0076 (Print)
ISSN 2587-5760 (Online)