Retinopathy of prematurity: indicators of cellular immunity in patients with various stages of the disease
https://doi.org/10.21516/2072-0076-2019-12-2-5-11
Abstract
Purpose: to study the role of cellular immunity in the development of retinopathy of prematurity (ROP).
Material and methods. 87 children were tested, including 60 with III — V stage ROP and posterior aggressive retinopathy that had gestational age from 25 to 32 weeks at birth, aged 1 month to 1 year (study group) and 27 healthy children of the same age (control group).
Results. No statistically significant differences of immunological parameters were revealed within the groups of children aged 1 to 3 months, 3.5 to 6 months, and 6.5 to 12 months. The gestational age at birth had no effect on the parameters studied. With increasing severity of ROP amid reduced indicators of T-regulatory cells, the number of B-cells (CD19 +) grew, T-natural killer cells (CD3 -/CD16 +CD56 +) reduced significantly (p < 0.05), and the number of CD4+ T-cells reduced showing the significance of (p < 0.01–0.05).
Conclusion. The obtained data testify to the emergence of autoimmune reactions and a decrease in the level of regulatory T-cells in a premature child, more pronounced in severe stages of ROP.
About the Authors
L. M. Balashova
Pirogov Russian National Research Medical University; Morozov Children City Clinical Hospital; International theoretical and practical tissue proliferation center
Russian Federation
Russian Federation
Dr. Med. Sci., head of scientific laboratory of pediatric ophthalmology, ophthalmologist, director
1, Ostrovitianova St., 117997, Moscow1/9, 4th Dobryninsky per., Moscow, 119049
29/14, Prechistenka St., 119134, Moscow
Y. D. Kuznetsova
Pirogov Russian National Research Medical University; Russian Children Clinical; International theoretical and practical tissue proliferation center
Russian Federation
Russian Federation
researcher, ophthalmologist, head of ophthalmology department
1, Ostrovitianova St., 117997, Moscow
117, Leninsky prosp., 117997, Moscow
29/14, Prechistenka St., 119134, Moscow
L. S. Korobova
Pirogov Russian National Research Medical University; International theoretical and practical tissue proliferation center
Russian Federation
Russian Federation
anesthesiologist, head of pediatric anesthesiologic department
1, Ostrovitianova St., 117997, Moscow
29/14, Prechistenka St., 119134, Moscow
E. P. Kantarzhi
Pirogov Russian National Research Medical University; International theoretical and practical tissue proliferation center
Russian Federation
29/14, Prechistenka St., 119134, Moscow
Russian Federation
Cand. Biol. Sci., Professor, senior researcher of scientific laboratory of pediatric ophthalmology, council member
1, Ostrovitianova St., 117997, Moscow29/14, Prechistenka St., 119134, Moscow
V. E. Mukhin
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
researcher of the department of cell technologies and regenerative medicine
1, Ostrovitianova St., 117997, Moscow
E. A. Cherkashina
Pirogov Russian National Research Medical University; International theoretical and practical tissue proliferation center
Russian Federation
senior laboratory assistant1, deputy director
1, Ostrovitianova St., 117997, Moscow
29/14, Prechistenka St., 119134, Moscow
Russian Federation
senior laboratory assistant1, deputy director
1, Ostrovitianova St., 117997, Moscow
29/14, Prechistenka St., 119134, Moscow
S. N. Bykovskaya
Pirogov Russian National Research Medical University
Russian Federation
Dr. Med. Sci., Professor, head of the department of cell technologies and regenerative medicine
1, Ostrovitianova St., 117997, Moscow
Russian Federation
Dr. Med. Sci., Professor, head of the department of cell technologies and regenerative medicine
1, Ostrovitianova St., 117997, Moscow
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Review
For citations:
Balashova L.M., Kuznetsova Y.D., Korobova L.S., Kantarzhi E.P., Mukhin V.E., Cherkashina E.A., Bykovskaya S.N. Retinopathy of prematurity: indicators of cellular immunity in patients with various stages of the disease. Russian Ophthalmological Journal. 2019;12(2):5-11. (In Russ.) https://doi.org/10.21516/2072-0076-2019-12-2-5-11
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