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Differential diagnosis of retinal capillary hemangiomas and vasoproliferative tumors

https://doi.org/10.21516/2072-0076-2019-12-2-39-47

Abstract

Purpose. To propose the major differential diagnostic criteria of retinal capillary hemangioma (RCH) and vasoproliferative tumor (VPT) aimed at increasing the efficiency of the diagnosis of these diseases.

Material and methods. A comprehensive ophthalmologic examination off 19 (26 eyes) patients, aged 19 to 66 (ave. 31.89 ± 11.30 yrs), with vascular neoplasms of peripheral localization included, beside the standard techniques, fundus photoregistration, fluorescent angiography (FAG), optical coherence tomography of the retina and a combined ultrasound testing using B scanning, echographic densitometry, colour Doppler imaging (CDI), and pulse Doppler imaging.

Results. Based on the analysis of the clinical picture and the results of the tests performed, the following differential diagnostic criteria were proposed: the age at which RCH and VPT developed, their localization in the eye fundus, and the value of the maximal systolic blood flow velocity in the central vein of the retina.

Conclusion. Differential diagnostics of RCH and VPT requires combined approaches and should take into account, in addition to case history and the clinical picture, also the results of instrumental testing techniques: FAG, echography and CDI.

About the Authors

V. V. Neroev
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation

Corresponding member of RAS, Dr. Med. Sci., Professor, director

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062





T. N. Kiseleva
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation

Dr. Med. Sci., Professor, head of ultrasound diagnostic department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062 



A. Yu. Novikova
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation

Ph. D. student, department of retinal and optic nerve pathology

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062 



M. V. Ryabina
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation

Cand. Med. Sci., Senior researcher, department of retinal and optic nerve pathology

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062 



P. A. Ilyukhin
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation

Cand. Med. Sci., Researcher, department of retinal and optic nerve pathology

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062 



K. A. Ramazanova
Moscow Helmholtz Research Institute of Eye Diseases
Russian Federation

Cand. Med. Sci., Researcher, ultrasound diagnostic department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062 





References

1. Chan C-C., Chew E.Y., Shen D., Hackett J., Zhuang Z. Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease. Mol Vis. 2005; 11: 697–704.

2. Vortmeyer A.O., Chan C-C., Chew E.Y., et al. Morphologic and genetic analysis of retinal angioma associated with massive gliosis in a patient with von Hippel — Lindau disease. Graefes Arch. Clin. Exp. Ophthalmol. 1999; 237: 513–7. https://doi.org/10.1007/s004170050

3. Neumann H.P., Eggert H.R., Weigel K., et al. Hemangioblastomas of the central nervous system. A 10-year study with special reference to von Hippel — Lindau syndrome. J. Neurosurg.1989; 70 (1): 24–30. doi: 10.3171/jns.1989.70.1.0024

4. Lonser R.R., Glenn G.M., Walther M., et al. von Hippel — Lindau disease. Lancet. 2003; 361 (9374): 2059–67. https://doi.org/10.1016/S0140-6736(03)13643-4

5. Webster A.R., Maher E.R., Moore A.T. Clinical characteristics of ocular angiomatosis in von Hippel — Lindau disease and correlation with germline mutation. Arch. Ophthalmol. 1999; 117 (3): 371–8. doi: 10.1001/archopht.117.3.371

6. Chan C.-C., Collins A.B., Chew E.Y. Molecular pathology of eyes with von Hippel — Lindau (VHL) disease: a review. Retina. 2007; 27 (1): 1–7. doi: 10.1097/01.iae.0000244659.62202.ee

7. Singh A.D., Shields C.L., Shields J.A. von Hippel — Lindau disease. Surv. Ophthalmol. 2001; 46 (2): 117–42. https://doi.org/10.1016/S0039-6257(01)00245-4

8. Maher E.R., Yates J.R., Harries R., et al.Clinical features and natural history of von Hippel — Lindau disease. QJ Med. 1990; 77 (283): 1151–63.

9. Huang C., Tian Z., Lai K., et al. Long-term therapeutic outcomes of photodynamic therapy-based or photocoagulation-based treatments on retinal capillary hemangioma. Photomed Laser Surg. 2018; 36 (1): 10–7. doi: 10.1089/pho.2017.4296

10. Koen S.-I., Kvintel' G. Fluorescence angiography in the diagnosis of fundus pathology. Neroev V.V., Ryabina M.V., eds. Moscow: Reytar; 2005 (in Russian).

11. Webster A.R., Maher E.R., Moore A.T. Clinical characteristics of ocular angiomatosis in von Hippel–Lindau disease and correlation with germline mutation. Arch. Ophthalmol. 1999; 117: 371–8. doi: 10.1001/archopht.117.3.371

12. Laatikainen L., Immonen I., Summanen P. Peripheral retinal angioma like lesion and macular pucker. Am. J. Ophthalmol. 1989; 108 (5): 563–6. https://doi.org/10.1016/0002-9394(89)90434-0

13. Gass J.D.M. Stereoscopic atlas of macular deseases. St. Louis etc.: CV Mosby Co.; 1977

14. Peyman G.A., Rednam K.R., Mottow-Lippa L., Flood T. Treatment of large von Hippel tumors by eye wall resection. Ophthalmology. 1983; 90: 840–7. https://doi.org/10.1016/S0161-6420(83)34481-X

15. Shields J.A., Shields C.L. Atlas of intraocular tumors. Philadelphia: Lippincott Williams and Wilkins; 1999.

16. Shields J.A., Joffe L., Guibor P. Choroidal melanoma clinically simulating a retinal angioma. Am. J. Ophthalmol. 1978; 85 (1): 67–71. https://doi.org/10.1016/S0002-9394(14)76667-X

17. Shields C.L., Shields J.A., Barrett J., De Potter P. Vasoproliferative tumors of the ocular fundus. Classification and clinical manifestations in 103 patients. Arch. Ophthalmol. 1995; 113: 615–23.

18. Lewis R.A., Cohemn M.H., Wise G.N. Cavernous hemangioma of the retina and optic disc: a report of three cases and review of the literature. Br. J. Ophthalmol. 1975; 59: 422–34.

19. Baines P., Hiscott P., McLeod D. Posterior non-vascularized proliferative extraretinopathy and peripheral nodular retinal telangiectasis. Trans. Ophthalmol. Soc. UK. 1982; 102: 487–91.

20. Hiscott P., Mudhar H.S. Is vasoproliferative (reactive retinal glioangiosis) part of the spectrum of proliferative vitreoretinopathy? Eye. 2009; 23: 1851–8. doi: 10.1038/eye.2008.351

21. Irvine F., O’Donnell N., Kemp E., Lee W.R. Retinal vasoproliferative tumors: surgical management and histological findings (comment). Arch. Ophthalmol. 2000; 118 (4): 563–9. doi: 10.1001/archopht.118.4.563

22. Barr C.C., Rice T.A., Michels R.G. Angioma-like mass in a patient with retrolental fibroplasia. Am. J. Ophthalmol. 1980; 89 (5): 647–50. https://doi.org/10.1016/0002-9394(80)90281-0

23. Shields J.A., Shields C.L., Honavar S.G., Demirci H. Clinical variations and complications of Coats disease in 150 cases: the 2000 Sanford Gifford Memorial Lecture. Am. J. Ophthalmol. 2001; 131 (5): 561–71. https://doi.org/10.1016/S0002-9394(00)00883-7

24. Rundle P., Shields J.A., Shields C.L., Singh A.D., Peairs R. Vasoproliferative tumour of the ocular fundus associated with Waardenburg’s syndrome. Eye. 2000; 14: 105–6. doi: 10.1038/eye.2000.27

25. Poole Perry L.J., Jakobiec F.A., Zakka F.R. Reactive retinal astrocytic tumors (so-called vasoproliferative tumors): histopathologic, immunohistochemical, and genetic studies of four cases. Am. J. Ophthalmol. 2013; 155 (3): 593–608. doi: 10.1016/j.ajo.2012.09.002

26. Shields C.L., Kaliki S., Al-Dahmash S., et al. Retinal vasoproliferative tumors: comparative clinical features of primary vs secondary tumors in 334 cases. JAMA Ophthalmol. 2013; 131 (3): 328–34. doi: 10.1001/2013.jamaophthalmol.524

27. Welch R.B. Von Hippel — Lindau disease: the recognition and treatment of early angiomatosis retinae and the use of cryosurgery as an adjunct to therapy. Trans. Am. Ophthalmol. Soc. 1970; 68: 367–424.

28. Schmidt D., Natt E., Neumann H.P. Long-term results of laser treatment for retinal angiomatosis in von Hippel — Lindau disease. Eur. J. Med. Res. 2000; 5 (2): 47–58.

29. Kat'kova E.A. Ultrasound diagnosis of bulk processes of the organ of sight. Moscow: Strom; 2011. (in Russian).

30. Neroev V.V., Kiseleva T.N., Sarygina O.I., Tolstik S.I. Features of hemodynamics of the eye in patients with rhegmatogenous retinal detachment in the early postoperative period. Ul'trazvukovaya i funkcional'naya diagnostika. 2011; 5: 112-4 (in Russian).

31. Gulani A.C., Morparia H., Bhatti S.S., Jehangir R.P. Colour Doppler sonography: a new investigative modality for intraocular spaceoccupying lesions. Eye. 1994; 8: 307–310. doi: 10.1038/eye.1994.62

32. Turell M.E., Singh A.D. Vascular tumors of the retina and choroid: diagnosis and treatment. Middle East Afr. J. Ophthalmol. 2010;17 (3): 191–200. doi: 10.4103/0974-9233.65486


Review

For citations:


Neroev V.V., Kiseleva T.N., Novikova A.Yu., Ryabina M.V., Ilyukhin P.A., Ramazanova K.A. Differential diagnosis of retinal capillary hemangiomas and vasoproliferative tumors. Russian Ophthalmological Journal. 2019;12(2):39-47. (In Russ.) https://doi.org/10.21516/2072-0076-2019-12-2-39-47

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ISSN 2072-0076 (Print)
ISSN 2587-5760 (Online)