Mathematical modeling of fluid movement inside the eyeball during intravitreal injection
https://doi.org/10.21516/2072-0076-2022-15-2-37-41
Abstract
Intravitreal injections show an avalanche-like growth the world over.
Purposes: 1) create a mathematical model of the eyeball and fluid movement inside the eye, assuming the simplified structure of the vitreous body (without tanks); 2) estimate the time span when the drug substance remains in the cavity of the vitreous body until it is completely washed out, depending on the injection site; 3) observe and evaluate the path of drug movement in the vitreous body cavity; 4) evaluate the variation of time when the drug is located in the vitreous body cavity, depending on the presence or absence of complete detachment of the vitreous body.
Results. If the drug is injected closer to the center of the eyeball, the time when it is located in the vitreous is increased as compared to parietal injection. With full vitreous body detachment, the location time of the drug increases as compared to its normal location, which favorably affects the prolongation of the therapeutic effect.
Conclusion. As this is a pilot study, many parameters are approximate, so the results obtained cannot be mechanically extrapolated to the live human eye subjected to intravitreal injections, due to the complexity of the processes occurring in eyeball.
Supporting agencies: No author has a financial or property interest in any material or method mentioned
About the Authors
D. V. Lipatov
National Endocrinology Research center
Russian Federation
Russian Federation
Dmitry V. Lipatov, Dr. of Med. Sci., professor, head of the department
department of diabetic retinopathy and ophthalmic surgery
117036
11, Dmitry Ulyanov St.
Moscow
S. A. Skladchikov
Lomonosov Moscow State University
Russian Federation
Russian Federation
Sergey A. Skladchikov, Cand. of Phys.-Math. Sci., research associate
chair of computational mathematics and cybernetics
119991
1, Bldg. 52, Leninskie Gory, GSP-1
Moscow
N. P. Savenkova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Nadezhda P. Savenkova, Dr. of Phys.-Math. Sci., principal researcher
faculty of computational mathematics and cybernetics
119991
1, Bldg. 52, Leninskie Gory, GSP-1
Moscow
V. V. Novoderezkin
City clinical hospital No.15
Russian Federation
Russian Federation
Vladimir V. Novoderezkin, Cand. of Med. Sci., ophthalmologist
111539
23, Veshnyakovskaya St.
Moscow
Ph. I. Vysikailo
Moscow Regional State University
Russian Federation
Russian Federation
Philip I. Vysikailo, Dr. of Phys.-Math. Sci., professor
chair of theoretical physics
141014
24, Vera Voloshina St.
Moscow region
Mytishchi
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Review
For citations:
Lipatov D.V., Skladchikov S.A., Savenkova N.P., Novoderezkin V.V., Vysikailo P.I. Mathematical modeling of fluid movement inside the eyeball during intravitreal injection. Russian Ophthalmological Journal. 2022;15(2):37-41. (In Russ.) https://doi.org/10.21516/2072-0076-2022-15-2-37-41
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