Preview

Russian Ophthalmological Journal

Advanced search

Repeated micropulse cyclophotocoagulation in the treatment of refractory glaucoma. A clinical experience

https://doi.org/10.21516/2072-0076-2022-15-3-18-25

Abstract

Purpose: to analyze the results of repeated micropulse transscleral cyclophotocoagulation (mTSCPC) in the treatment of refractory glaucoma (RG).

Material and methods. We examined 74 patients aged 73.2 ± 6.3 years with developed (13), advanced (48) and terminal (13) stages of refractory glaucoma before and within 15 months after the first mTSCPC (SUPRA 810, Quantel Medical, France) using standard laser parameters — 100 J. According to indications, the repeated mTSCPC was performed for 17 patients. Of these, 4 patients had the second procedure three months after the first procedure, 10 patients — 6 months after it, and 3 patients, 9 months after the first procedure. The repeated mTSCPC was performed with an impact energy higher than the first one — 125 J.

Results. After the first procedure, the hypotensive effect was held in 57 patients with RG (77.0 %) up to 15 months of the follow-up. The repeated mTSCPC given to 17 patients made it possible to reduce intraocular pressure (IOP) by 38.5 % for the developed RG stage, by 33.9 % for the advanced stage, and by 21.4 % at the terminal stage (p < 0.05) by 6–12 months of follow-up. The hypotensive effect was held in 13 out of 17 patients by the end of the follow-up.

Сonclusion. Single and repeated mTSCPC with laser energies of 100 J and 125 J are effective and safe techniques of RH treatment. Possibly, it is worth revising the basic parameters of the mTSCPC procedure from 100 to 125 J to achieve a longer and at the same time safe hypotensive effect in patients with RG.

About the Authors

I. E. Ioshin
Clinical Hospital
Russian Federation

Igor E. Ioshin — Dr. of Med. Sci., professor, head of the Center of Ophthalmology.

45, Losinoostrovskaya St., Moscow, 107143



A. I. Tolchinskay
Clinical Hospital
Russian Federation

Anna I. Tolchinskaya — Dr. of Med. Sci., ophthalmologist.

45, Losinoostrovskaya St., Moscow, 107143



I. V. Maksimov
Clinical Hospital
Russian Federation

Igor V. Maksimov — ophthalmologist.

45, Losinoostrovskaya St., Moscow, 107143



A. V. Rakova
Clinical Hospital
Russian Federation

Anna V. Rakova — Cand. of Med. Sci., ophthalmologist.

45, Losinoostrovskaya St., Moscow, 107143



References

1. Egorov E.A. National Guidelines for Glaucoma Practitioners. Moscow: GEOTAR-Media; 2011 (in Russian).

2. Astakhov Yu.S., Egorov E.A., Astakhov S.Yu., Brezel Y.A. Surgical treatment of refractory glaucoma. RMJ. Clinical Ophthalmology. 2006; 7 (1): 25–7 (in Russian).

3. Erichev V.P. Refractory glaucoma: treatment features. Vestnik oftal’mologii. 2000; 116 (5): 8–10 (in Russian).

4. Bessmertny A.M., Chervyakov A.Yu. The use of implants in the treatment of refractory glaucoma. Glaucoma. 2001; 1: 4–7 (in Russian).

5. Bessmertny A.M. On the issue of differentiated surgical treatment of the main forms of refractory glaucoma. RMJ. Clinical Ophthalmology. 2002; 3 (2): 59–60 (in Russian).

6. Krasnov M.M., Naumidi L.P. Transscleral contact laser cyclophotocoagulation for glaucoma. Vestnik oftal`mologii. 1988; 104 (4): 35–9 (in Russian).

7. Boyko E.V., Kulikov A.N., Skvortsov V.Y. Comparative evaluation of diode laser thermotherapy and laser coagulation as methods of cyclodestruction (experimental study). Practical medicine. 2012; 59 (4–1): 175–9 (in Russian).

8. Zaarour K., Abdelmassih Y., Arej N., et al. Outcomes of Micropulse Transscleral Cyclophotocoagulation in uncontrolled glaucoma patients. J. Glaucoma. 2019; 28 (3): 270–5. https://doi:10.1097/IJG.0000000000001174

9. Maslin J.S., Chen P.P., Sinard J., Nguyen A.T., Noecker R. Histopathologic changes in cadaver eyes after MicroPulse and continuous wave transscleral cyclophotocoagulation. Canadian Journal of Ophthalmology. 2020; 55 (4): 330–5. https://doi:10.1016/j.jcjo.2020.03.010

10. Aquino M.C., Barton K., Tan A.M., et al. Micropulse versus continuous wave transscleral diode cyclophotocoagulation in refractory glaucoma: a randomized exploratory study. Clin. Exp. Ophthalmol. 2015; 4 3(1): 40–6. https://doi: 10.1111/ceo.12360pmid:24811050

11. Williams A.L., Moster M.R., Rahmatnejad K., et al. Clinical efficacy and safety profile of Micropulse Transscleral Cyclophotocoagulation in refractory glaucoma. J. Glaucoma. 2018; 27 (5): 445–9. https://doi: 10.1097/IJG.0000000000000934pmid:29521718

12. Sanchez F.G., Lerner F., Sampaolesi J., Noecker R., et al. Efficacy and Safety of Micropulse(R) Transscleral Cyclophotocoagulation in Glaucoma. Arch. Soc. Esp. Oftalmol. 2018; 93 (12): 573–9. https://doi:10.1016/j.oftal.2018.08.003pmid:30290978

13. Tan A.M., Chockalingam M., Aquino M.C., et al. Micropulse transscleral cyclophotocoagulation in the treatment of refractory glaucoma. Clin. Exp. Ophtalmol. 2010; 38 (3): 266–72. doi: 10.1111/j.1442-9071.2010.02238.x

14. Aquino M.C., Lim D., Chew P.T. Micropulse P3™(MP3) Laser for Glaucoma: An Innovative Therapy. J. Cur. Glaucoma Pract. 2018; 12 (2): 51–2. https://doi:10.5005/jp-journals-10008-1244

15. Khodzhaev N.S., Sidorova A.V., Starostina A.V., Eliseeva M.A. Micropulse transscleral cyclophotocoagulation in combined surgical treatment of refractory glaucoma. Modern technologies in ophthalmology. 2019; 4: 95–8 (in Russian). https://doi.org/10.25276/2312-4911-2019-4-95-98

16. Emanuel M.E., Grover D.S., Fellman R.L., et al. Micropulse Cyclophotocoagulation: initial results in refractory glaucoma. J. Glaucoma. 2017; 26 (8): 726–9. https://doi.org/10.1097/IJG.0000000000000715

17. Souissi S., Baudouin C., Labbé A., Hamard P. Micropulse transscleral cyclophotocoagulation using a standard protocol in patients with refractory glaucoma naive of cyclodestruction. Eur. J. Ophthalmol. 2021; 31 (1): 112–9. https://doi:10.1177/1120672119877586

18. Schlote T., Greb M., Kynigopoulos M. Long-term results after transscleral diode laser cyclophotocoagulation in refractory posttraumatic glaucoma and glaucoma in aphakia. Graefes Arch. Clin. Exp. Ophthalmol. 2008; 246 (3): 405–10. https://doi:10.1007/s00417-007-0708-0

19. Tolchinskaya A.I., Ioshin I.E., Maksimov I.V. Application of microinvasive cyclophotocoagulation (MP-TSCPC) in patients with refractory glaucoma. Modern technologies in ophthalmology. 2020; 4 (35): 151–2 (in Russian). https://doi.org/10.25276/2312-4911-2020-4-151-152

20. Pantcheva M.B., Kahook M.Y., Schuman J.S., Noecker R.J. Comparison of acute structural and histopathological changes in human autopsy eyes after endoscopic cyclophotocoagulation and trans-scleral cyclophotocoagulation. Br. J. Ophthalmol. 2007; 91 (2): 248–52. https://doi:10.1136/bjo.2006.103580pmid:16987899

21. Masi M., Lin S.C., Babic K. Micropulse transscleral diode laser cyclophotocoagulation: Mid to long-term results. The 26th Annual AGS Meeting. Coronado: CA2017.

22. Kuchar S., Moster M.R., Reamer C.B., Waisbourd M. Treatment outcomes of micropulse transscleral cyclophotocoagulation in advanced glaucoma. Lasers Med. Sci. 2016; 31 (2): 393–6. doi: 10.1007/s10103-015-1856-9

23. Garcia G.A., Nguyen C.V., Yelenskiy A., et al. Micropulse transscleral diode laser cyclophotocoagulation in refractory glaucoma. Ophthalmology Glaucoma, 2019; 2 (6): 402–12. doi: 10.1016/j.ogla.2019.08.009

24. Nguyen M., Noecker M. Micropulse trans-scleral cyclophotocoagulation for the treatment of glaucoma. The 26th Annual AGS Meeting. Coronado: CA2017.

25. Shazly M., Tarek A. Outcomes of micropulse transscleral cyclophotocoagulation in medically uncontrolled glaucoma. The 26th Annual AGS Meeting. Coronado: CA2017.


Review

For citations:


Ioshin I.E., Tolchinskay A.I., Maksimov I.V., Rakova A.V. Repeated micropulse cyclophotocoagulation in the treatment of refractory glaucoma. A clinical experience. Russian Ophthalmological Journal. 2022;15(3):18-25. (In Russ.) https://doi.org/10.21516/2072-0076-2022-15-3-18-25

Views: 1150


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-0076 (Print)
ISSN 2587-5760 (Online)