Electroretinography and OCT angiography of the retina and optic nerve in retinitis pigmentosa

OCT angiography, an innovative noninvasive technique, allows a comprehensive assessment of eye vessels, separately for the choroidal and the retinal vasculature. Purpose: to assess microcirculation changes in the macular and peripapillary areas of the retina in retinitis pigmentosa (RP) by OCT angiography in comparison with electrogenesis parameters of the macular area of the retina and the cone system. Material and methods. The results of microcirculation studies of the fovea and the optic disk were analyzed for 14 patients with RP aged 5 to 76 (mean age 26.9 ± 17.6 years). OCT angiography was performed with Optovue RX Avanti (Optovue, USA). Рarafoveal vessel density, blood flow index, blood flow area, the size of the foveal avascular zone (FAZ) in the superficial and deep capillary plexuses and the flow area in retinal peripapillary capillaries (RPC) were assessed. All patients were tested by electroretinography using the MBN electroretinograph (Russia), including the general electroretingram (ERG), the maximal ERG, 30 Hz flicker ERG, and the macular ERG (MERG). Results. Blood flow deficit in superficial and deep capillary plexuses and in peripapillary capillaries (decreased parafoveal vessel density, vascular index, flow area) was associated with the reduction of a- and b-wave amplitudes of MERG and the increase of the implicit time. The enlargement of FAZ found in the deep capillary plexus (DCP) (p < 0.0001).and the normal size of FAZ in superficial capillary plexus (SCP) may be due to the difference in their structures. Conclusion. The blood flow deficit, which is more pronounced in DCP than in SCP in the macula of RP patients, is associated with the reduction of a- and b-wave amplitudes of MERG and the increase of the implicit time Russian ophthalmological journal. 2017; 10 (3): 22-28. doi: 10.21516/2072-0076-2017-10-3-22-28 // (in Russian). For citations: Zolnikova I.V., Levina D.V., Okhotsimskaya T.D., et al. Electroretinography and OCT angiography of the retina and optic nerve in retinitis pigmentosa. Russian ophthalmological journal. 2017; 10 (3): 22-28. doi: 10.21516/2072-0076-2017-10-3-22-28 (in Russian).

пигментный ретинит, электроретинограмма, макулярная ЭРГ, ОКТ-ангиография, глубокое капиллярное сплетение, поверхностное капиллярное сплетение, ретинальные перипапиллярные капилляры, плотность сосудистой сети в парафовеа, сосудистый индекс, площадь кровотока, фовеальная аваскулярная зона, retinitis pigmentosa, electroretinogram, macular ERG, OCT angiography, superficial capillary plexuses, deep capillary plexuses, retinal peripapillary capillaries, parafoveal vessel density, vascular index, flow area, foveal avascular zone

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