The infectious status of patients with optic neuritis of inflammatory and demyelinating etiologies
https://doi.org/10.21516/2072-0076-2023-16-3-54-59
Abstract
Purpose: to study the prevalence of various chronic infections, the frequency of their reactivation and characteristic associations of microorganisms in patients with optic neuritis of various etiologies.
Material and methods. 13 patients with optic neuritis (ON) and 12 patients with ON and multiple sclerosis were tested for a broad range of infectious agents in their blood serum.
Results. All patients were shown to have mixed infections; 64 % of them had an association of 4 or more infectious agents. The patients of both groups were infected with Epstein-Barr virus (100 %), Cytomegalovirus (92 %) and Herpex simplex viruses (92 %) types 1 and/or 2 with serological signs of their reactivation. The combination of Herpes virus reactivation, Toxoplasma and urogenital infection was more often detected in patients with demyelinating ON. In patients with multiple sclerosis, a mutual correlation was detected: the higher the degree of infection (combination of 5 or more pathogens), the lower the visual acuity at the onset of the disease (p < 0.05) and the less favourable the vision prognosis.
Conclusion. Possibly, mixed infection may play an important role in the pathogenesis of ON, including that of demyelinating etiology, as a trigger or an aggravating factor.
About the Authors
V. V. Neroev
Helmholtz National Medical Research Center of Eye Diseases; Moscow Evdokimov State Medical Stomatological University
Russian Federation
Russian Federation
Vladimir V. Neroev - Academician of the RAS, Dr. of Med. Sci., professor, director, head of chair of eye diseases
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
20, Bldg. 1, Delegatskaya St., Moscow, 127473
E. K. Eliseeva
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Elena K. Eliseeva - Cand. of Med. Sci., researcher of ultrasound diagnostic department
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
G. I. Krichevskaya
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Galina I. Krichevskaya - Cand. of Med. Sci., doctor of clinical laboratory diagnostics, department of immunology and virusology
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
G. A. Davydova
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Galina A. Davydova - Cand. of Med. Sci., researcher, department of pathology of the retina and optic nerve
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
M. N. Zakharova
Research Center of Neurology
Russian Federation
Russian Federation
Maria N. Zakharova - Dr. of Med. Sci., head of 6th department
80, Volokolamskoye Hgwy, 125367, Moscow
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For citations:
Neroev V.V., Eliseeva E.K., Krichevskaya G.I., Davydova G.A., Zakharova M.N. The infectious status of patients with optic neuritis of inflammatory and demyelinating etiologies. Russian Ophthalmological Journal. 2023;16(3):54-59. (In Russ.) https://doi.org/10.21516/2072-0076-2023-16-3-54-59
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