Glaucoma and Arterial Hypertension
https://doi.org/10.21516/2072-0076-2016-9-1-105-111
Abstract
Arterial hypertension occurs in 48-65 % patients with primary open-angle glaucoma. It is the most frequent systemic disease among these patients. On the other hand, it is an independent risk factor for primary open-angle glaucoma which must be taken into consideration in the development of the glaucoma treatment strategy. The low influence on the intraocular pressure and the significant perfusion disturbances cause damages to the whole visual system, which in its turn exacerbates the detrimental effects of the intraocular pressure elevation on the glaucomatous optic neuropathy. It is necessary to keep blood pressure at a normal level and to avoid the absence of night-time blood pressure dipping or extreme dipping, as the hypotensive phases impair the autoregulation of papillary blood flow, which finally leads to the emergence of ischemic areas. Intraocular pressure reduction is only one of the aspects of the antiglaucomatous therapy, since it does not prevent the progression of glaucomatous optic neuropathy. In this case, intensive interaction of various medical disciplines is required for the long-term stabilization of the glaucoma process // Russian Ophthalmological Journal, 2016; 1: 105-111.
About the Author
Carl Erb
Private Institute of Applied Ophthalmology, Berlin, Federal Republic of Germany
Russian Federation
Russian Federation
References
1. Leske M.C., Heijl A., Hyman L., et al. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology. 2007; 114: 1965-72.
2. Grieshaber M.C., Mozaffarieh M., Flammer J. What is the link between vascular dysregulation and glaucoma ? Surv Ophthalmol. 2007; 52: 144-154.
3. Erb C., Heinke M. Oxidative stress in primary open-angle glaucoma. Front Biosci. 2011; 3: 1524-33.
4. Rivera J.L., Bell N.P., Feldman R.M. Risk factors for primary open angle glaucoma progression: what we know and what we need to know. Curr Opin Ophthalmol. 2008; 19: 102-6.
5. Schröder A., Falk S., Wollstein J., Meyer M., Erb C. Morphologie der Papille bei Patienten mit einer arteriellen Hypertonie. Z prakt Augenheilkd. 2003; 24: 376-8.
6. Schröder A., Erb C., Falk S., et al. Farbsinnstörungen bei Patienten mit einer arteriellen Hypertonie. Ophthalmologe. 2002; 99: 375-9.
7. Mitchell P., Lee A.J., Rochtchina E., Wang J.J. Open-angle glaucoma and systemic hypertension: the blue mountains eye study. J. Glaucoma. 2004; 13: 319-26.
8. Isakova L.S., Danilov G.E., Egorkina S.B., Butolin E.G. Hormonal homeostasis and intraocular pressure in chronic emotional stress caused by influences acting on the amygdala. Fiziol Zh SSSR im I.M. Sechenova. 1989; 75: 124-30.
9. Fuchsjager-Mayrl G., Wally B., Georgopoulos M., et al. Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci. 2004; 45: 834-9.
10. Leske M.C., Wu S.Y., Hennis A., Honkanen R., Nemesure B. BESs Study Group. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology. 2008; 115: 85-93.
11. Burgoyne C.F., Downs J.C., Bellezza A.J., Suh J.K.F., Hart R.T. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog Ret Eye Res. 2005; 24: 39-73.
12. Topouzis F., Coleman A.L., Harris A., et al. Association of blood pressure status with the optic disk structure in non-glaucoma subjects: the Thessaloniki eye study. Am J Ophthalmol. 2006; 142: 60-7.
13. German Hypertension League DHL®. Guidelines for the treatment of arterial hypertension. AWMF register no. 046/001.
Review
For citations:
Erb C. Glaucoma and Arterial Hypertension. Russian Ophthalmological Journal. 2016;9(1):105-111. (In Russ.) https://doi.org/10.21516/2072-0076-2016-9-1-105-111
Views:
13324
Email this article 