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Sonography of the lacrimal gland: historical aspects and possibilities of modern technologies

https://doi.org/10.21516/2072-0076-2025-18-3-133-138

Abstract

The review summarizes the data of domestic and foreign studies of the lacrimal gland (LG) using various echography techniques (A-scan, B-mode, color Doppler mapping (CDM), three-dimensional echography). Despite the generally accepted standards of using computed tomography and magnetic resonance imaging to visualize orbital structures, the presence of absolute and relative contraindications limits their use. Ultrasound methods are accessible, non-invasive, and highly informative for obtaining objective parameters necessary for diagnosis and evaluation of the effectiveness of treatment of LG pathology. Modern echography methods provide important information on the anatomical, topographic and structural characteristics, biometric indicators of the LG in various pathological changes. CDM is used to determine not only the features of the LG blood supply and the state of blood flow in the retrobulbar vessels, but also the presence or absence of vascularization of LG neoplasms. A comprehensive ultrasound examination, including B-mode, color Doppler imaging, and echodensitometry, is becoming a necessary diagnostic method for LG diseases, allowing for optimization of patient treatment tactics and, when planning surgical intervention, determining the size and structure of the pathological lesion. However, questions about the standard LG sizes in individuals of different age groups and their changes in various systemic diseases and pathologies of the visual organ remain controversial. Further study of the comparability of LG measurement results by various visualization methods is required.

About the Authors

T. N. Kiseleva
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation

Tatiana N. Kiseleva — Dr. of Med. Sci., professor, head of ultrasound department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062



M. S. Zaitsev
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation

Maxim S. Zaitsev — Cand. of Med. Sci., researcher of ultrasound department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062



K. V. Lugovkina
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation

Ksenija V. Lugovkina — Cand. of Med. Sci., researcher of ultrasound department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062



A. A. Zaitseva
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation

Alina A. Zaitseva — ophthalmologist of the adult advisory polyclinic department

14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062



References

1. Mustafaev A.S. Clinical anatomy of the lacrimal apparatus. Mezhdunarodnyi studencheskii nauchnyi vestnik. 2019; 1: 46–58 (In Russ.).

2. Takahashi Y, Watanabe A, Matsuda H, et al. Anatomy of secretory glands in the eyelid and conjunctiva: a photographic review. Ophthalmic Plast Reconstr Surg. 2013; 29 (3): 215–9. doi: 10.1097/IOP.0b013e3182833dee

3. Mircheff AK. Lacrimal fluid and electrolyte secretion: a review. Curr Eye Res. 1989; 8 (6): 607–17. doi: 10.3109/02713688908995761

4. Dartt DA. Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res. 2009; 28 (3): 155–77. doi:10.1016/j.preteyeres.2009.04.003

5. Walcott B. The lacrimal gland and its veil of tears. News Physiol Sci. 1998; 13: 97–103. doi: 10.1152/physiologyonline.1998.13.2.97

6. Garg A, Zhang X. Lacrimal gland development: From signaling interactions to regenerative medicine. Dev Dyn. 2017; 246 (12): 970–80. doi: 10.1002/dvdy.24551

7. Kopaeva V.G. Eye diseases. Fundamentals of ophthalmology: textbook Moskva: Meditsina; 2012 (In Russ.).

8. Reese AB. The treatment of lesions of the lacrimal gland. Trans Am Acad Ophthalmol Otolaryngol. 1958 Sep-Oct; 62 (5): 679–83. PMID: 13603478.

9. Shields CL, Shields JA, Eagle RC, et al. Clinicopathologic review of 142 cases of lacrimal gland lesions. Ophthalmology. 1989 Apr; 96 (4): 431–5. doi: 10.1016/s0161-6420(89)32873-9

10. Andreoli MT, Aakalu V, Setabutr P. Epidemiological trends in malignant lacrimal gland tumors. Otolaryngol Head Neck Surg. 2015 Feb; 152 (2): 279–83. doi: 10.1177/0194599814556624

11. Yatsenko O.Yu., Tyurin I.E. Possibilities of computed tomography in the diagnosis of epithelial formations of the lacrimal gland. Vestnik rentgenologii i radiologii. 2018; 99 (3): 134–40 (In Russ.).

12. Chepurina A.A., Sviridenko N. Yu., Remizov O.V., et al. Imaging research methods in the diagnosis of endocrine ophthalmopathy. Meditsinskaya vizualizatsiya. 2012; 1: 36–44 (In Russ.).

13. Hughes GK, Miszkiel KA. Imaging of the lacrimal gland. Semin Ultrasound CT MR. 2006; 27 (6): 476–91. doi: 10.1053/j.sult.2006.09.002

14. Nawaz S, Lal S, Butt R, et al. Computed tomography evaluation of normal lacrimal gland dimensions in the adult Pakistani population. Cureus. 2020; 24: 12: 3: 7393. doi: 10.7759/cureus.7393

15. Fletcher JG, Kofler JM, Coburn JA, et al. Perspective on radiation risk in CT imaging. Abdom Imaging. 2013 Feb; 38 (1): 22–31. doi: 10.1007/s00261-012-9933-z

16. Lyubavska V., Beldovskaya N.Yu., Novikov S.A., et al. Radiation methods for diagnosing the pathology of the lacrimal ducts. Oftal’mologicheskie vedomosti. 2017; 10 (3): 35–45 (In Russ.). doi: 10.17816/OV10335-45

17. Hughes GK, Miszkiel KA. Imaging of the lacrimal gland. Semin Ultrasound CT MR. 2006; 27 (6): 476–91. doi: 10.1053/j.sult.2006.09.002

18. Gunduz K, Shields CL, Gunalp I, et al. Magnetic resonance imaging of unilateral lacrimal gland lesions. Graefes Arch Clin Exp Ophthalmol. 2003 Nov; 241 (11): 907–13. doi: 10.1007/s00417-003-0748-z

19. Nair JR, Syed R, Chan IYM, et al. The forgotten lacrimal gland and lacrimal drainage apparatus: pictorial review of CT and MRI findings and differential diagnosis. Br J Radiol. 2022; 95 (1135): 333. doi: 10.1259/bjr.20211333

20. Byrne SF. Standardized echography of the eye and orbit. Neuroradiology. 1986; 28 (5–6): 618–40. doi: 10.1007/BF00344110

21. Ossoinig K. Die Ultraschalldiagnostik der Tumoren in der Augenhöhle. Albrecht von Graefes Arch Klin Ophthalmol. 1967; 172: 364–82. https://doi.org/10.1007/BF02384796

22. Giovagnorio F, Pace F, Giorgi A. Sonography of lacrimal glands in Sjögren syndrome. J Ultrasound Med. 2000; 19: 8: 505–9. doi: 10.7863/jum.2000.19.8.505

23. Ahuja AT, Metreweli C. Ultrasound features of Sjögren’s syndrome. Australas Radiol. 1996 Feb; 40 (1):10–4. doi: 10.1111/j.1440-1673.1996.tb00336.x

24. Yang T, Delli K, Coumou AD, et al. The lacrimal gland in Sjögren’s syndrome: can we unravel its mystery using ultrasound? Clin Exp Rheumatol. 2022; 40 (12): 2428–33. doi: 10.55563/clinexprheumatol/z1lzb1

25. Kharlap S.I. Vascular architectonics of the eye and orbital space in color display of Doppler spectrum energy. Vestnik oftal’mologii. 1999; 115 (4): 30–3 (In Russ.).

26. Avetisov S.E., Kharlap S.I., Markosyan A.G. Ultrasound spatial clinical analysis of the orbital part of the lacrimal gland in the norm. Vestnik oftal’mologii. 2006; 122 (6): 14–6 (In Russ.).

27. Kharlap S.I., Nasnikova I.Yu., Markosyan A.G., et al. Structural features of the lacrimal gland in normal and pathological conditions according to the results of spatial ultrasound digital examination. Vestnik oftal’mologii. 2011; 127 (4): 16–24 (In Russ.).

28. Eksarenko O. V., Kharlap S. I., Safonova T. N., et al. Changes in the lacrimal gland in sarcoidosis according to the results of spatial ultrasound digital examination. Vestnik oftal’mologii. 2013; 129 (1): 10–5 (In Russ.).

29. Safonova T.N., Kharlap S.I., Eksarenko O.V., et al. Changes in the lacrimal glands and tissues of the orbit in IgGA-related disease according to ultrasound. Tochka zreniya. Vostok — Zapad. 2017: 3: 86–9 (In Russ.).

30. Guidance for Industry and FDA staff/ Information for Manufacturers Seeking Marketing Clearance of Diagnostic Ultrasound Systems and Transducers (Appendix от 30.09.97 E). Silver Spring; 2008. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/marketing-clearance-diagnostic-ultrasound-systems-and-transducers

31. Kiseleva T.N., Lugovkina K.V., Zaitsev M.S. The method of ultrasound examination of the lacrimal gland. Patent RF N 2759385, 2021 (In Russ.).

32. Yılmaz H, Güneş İB. Evaluation of main lacrimal gland through shear-wave ultrasound elastography in patients with low Schirmer value. Curr Med Imaging. 2023: 8. doi: 10.2174/1573405620666230608091854

33. Świecka M, Paluch Ł, Pietruski P, et al. Applicability of shear wave elastography for lacrimal gland evaluation in primary Sjögren syndrome. Pol Arch Intern Med. 2023; 133 (2): 16397. doi: 10.20452/pamw.16397


Review

For citations:


Kiseleva T.N., Zaitsev M.S., Lugovkina K.V., Zaitseva A.A. Sonography of the lacrimal gland: historical aspects and possibilities of modern technologies. Russian Ophthalmological Journal. 2025;18(3):133-138. (In Russ.) https://doi.org/10.21516/2072-0076-2025-18-3-133-138

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ISSN 2072-0076 (Print)
ISSN 2587-5760 (Online)