Assessment of the survival rate of patients with malignant neoplasms of the choroid in the Orenburg region
https://doi.org/10.21516/2072-0076-2025-18-4-19-24
Abstract
The purpose of the work is to analyze the impact of various factors on the survival of patients with malignant neoplasms of the choroid.
Materials and methods. A retrospective analysis of the databases of the V.I. Voynov Orenburg State Clinical Eye Hospital for 2013–2022 was carried out. Among the cases of complaints about malignant neoplasms of the vascular membrane (ICD code C69.3), cases with uveal melanoma were selected. The survival rate of the patients was calculated.
Results. Among the completed cases, the most common cause of death was malignant neoplasm of the vascular membrane. The study showed that age and gender do not affect survival rates (p ˃ 0,05). However, among the examined cases, survival was higher among urban residents compared with rural residents (p = 0.019). Also, higher survival rates were demonstrated in the group of patients who underwent laser treatment (p = 0.017). In addition, survival is higher among patients treated at stage 1 of the disease than among patients treated at stage 4 of the disease (p = 0.00140).
Conclusions. The life prognosis of patients with malignant neoplasms of the choroid is favorably influenced by living in an urban area, treating the disease at an early stage using organ-preserving techniques.
About the Authors
A. E. Aprelev
Orenburg State Medical University
Russian Federation
Russian Federation
Alexander E. Aprelev — Dr. of Med. Sci., associate professor, head of chair of ophthalmology
6, Sovetskaya St., Orenburg, 460000
D. N. Begun
Orenburg State Medical University
Russian Federation
Russian Federation
Dmitry N. Begoun — Dr. of Med. Sci., associate professor, head of chair of nursing
6, Sovetskaya St., Orenburg, 460000
I. I. Zakirova
Orenburg State Medical University
Russian Federation
Russian Federation
Irina I. Zakirova — PhD student, ophthalmologist, chair of ophthalmology
6, Sovetskaya St., Orenburg, 460000
S. A. Shmitkova
Orenburg State Medical University
Russian Federation
Russian Federation
Sofya A. Shmitkova — student
6, Sovetskaya St., Orenburg, 460000
References
1. Myakoshina E.B., Sahakian S.V. Features of visual functions, their correlation with macular OCT angiography in patients with initial choroidal melanoma. Clinical ophthalmology. 2022; 22 (4): 216–23 (In Russ.). doi: 10.32364/2311-7729-2022-22-4-216-223
2. Gurko T.S. Clinic and differential diagnosis of choroid nevus. Modern problems of science and education. 2021; 4: 100 (In Russ.). https://doi.org/10.17513/spno.31018
3. Khodjaev N. S., Sobolev N.P., Shkondina Yu.V., Soboleva M.A. Modern possibilities of optical reconstructive surgery in patients after removal of an iridociliary tumor. Fyodorov journal of ophthalmic surgery. 2021; 2: 48–51 (In Russ.). https://doi.org/10.25276/0235-4160-2021-2-48-51
4. Brovkina A.F. Local treatment of choroid melanomas: possibilities and limitations. Vestnik oftal’mologii. 2018; 134 (4): 52–60 (In Russ.). doi: 10.17116/oftalma201813404152
5. Amiryan A.G., Sahakyan S.V. Prognostic factors of uveal melanoma. Vestnik oftal’mologii. 2015; 1 (1): 90–5 (In Russ.). doi: 10.17116/oftalma2015131190-94
6. СSahakian S.V., Myakoshina E.B., Zakharova G.P., Garry D.D. Survival rate of patients with uveal melanoma of small and medium size. Effective pharmacotherapy. 2020; 16 (21): 18–22 (In Russ.). doi: 10.33978/2307-3586-2020-16-21-18-22
7. Saakyan S.V., Amiryan A.G., Tsygankov A.Yu., Khlgatyan M.R. Long-term survival of uveal melanoma patients with respect to clinical, hemodynamic and morphological characteristics of the tumor. Russian ophthalmological journal. 2022; 15 (2): 85–91 (In Russ.). https://doi.org/10.21516/2072-0076-2022-15-2-85-91
8. Shields CL, Furuta M, Thangappan A, et al. Metastasis of uveal melanoma millimeter-by-millimeter in 8033 consecutive eyes. Arch Ophthalmol. 2009; 127 (8): 989–98. doi: 10.1001/archophthalmol.2009.208
9. Saakyan S.V., Zakharova G.P., Myakoshina E.B. Cellular microenvironment of uveal melanoma: clinical and morphological correlations and predictors of bad prognosis. Molecular medicine. 2020; 18 (3): 27–33 (In Russ.). https://doi.org/10.29296/24999490-2020-03-04
10. Schmittel A, Bechrakis NE, Martus P, et al. Independent prognostic factors for distant metastases and survival in patients with primary uveal melanoma. Eur J Cancer. 2004; 40 (16): 2389–95. doi: 10.1016/j.ejca.2004.06.028
11. Lane AM, Egan KM, Kim IK, Gragoudas ES. Mortality after diagnosis of small melanocytic lesions of the choroid. Arch Ophthalmol. 2010; 128 (8): 996–1000. doi: 10.1001/archophthalmol.2010.166
12. Isager P, Ehlers N, Overgaard J. Prognostic factors for survival after enucleation for choroidal and ciliary body melanomas. Acta Ophthalmol Scand. 2004; 82 (5): 517–25. doi: 10.1111/j.1600-0420.2004.00330.x
13. Kujala E, Mäkitie T, Kivelä T. Very long-term prognosis of patients with malignant uveal melanoma. Invest Ophthalmol Vis Sci. 2003; 44: 4651–9. doi: 10.1167/iovs.03-0538
14. Damato B. Does ocular treatment of uveal melanoma influence survival? Br J Cancer. 2010; 103: 285–90. doi: 10.1038/sj.bjc.6605765
Review
For citations:
Aprelev A.E., Begun D.N., Zakirova I.I., Shmitkova S.A. Assessment of the survival rate of patients with malignant neoplasms of the choroid in the Orenburg region. Russian Ophthalmological Journal. 2025;18(4):19-24. (In Russ.) https://doi.org/10.21516/2072-0076-2025-18-4-19-24
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