Sub-tenon’s injection of recombinant prourokinase (Hemase) combined with intravitreal injection of a neoangiogenesis inhibitor (Eylea) in the treatment of massive subretinal hemorrhage in neovascular age-related macular degeneration. A clinical case
https://doi.org/10.21516/2072-0076-2025-18-4-132-138
Abstract
This paper describes a clinical case of neovascular age-related macular degeneration complicated by subretinal hemorrhage and analyzes the effectiveness of minimally invasive combination treatment, which included a sub-Tenon injection of recombinant prourokinase (Hemase) simultaneously with an intravitreal injection of a neoangiogenesis inhibitor (Eylea). This treatment resulted in significant positive results within a short period of time (1 month), including complete hemorrhage resorption and improved visual acuity, which made it possible to postpone or completely avoid open surgery.
About the Authors
M. T. Mikailova
Dagestan Center for Eye Microsurgery
Russian Federation
Russian Federation
Maysarat T. Mikailova — ophthalmologist, department of retinal pathology and laser surgery
12/2, M. Khalilova St., Kaspiysk, Republic of Dagestan, 368300
S. I. Zakieva
Dagestan Center for Eye Microsurgery;
Dagestan State Medical University
Russian Federation
Russian Federation
Savat I. Zakieva — Cand. of Med. Sci., head of the department of retinal pathology and laser surgery, Dagestan Center for Eye Microsurgery, associate professor of chair of eye diseases, Dagestan State Medical University
12/2, M. Khalilova St., Kaspiysk, Republic of Dagestan, 368300,
1 Lenin Square, Makhachkala, Republic of Dagestan, 367000
M. M. Magomedova
Dagestan Center for Eye Microsurgery;
Dagestan State Medical University
Russian Federation
Russian Federation
Maryam M. Magomedova — PhD student, Dagestan Center for Eye Microsurgery, assistant of the chair of eye diseases, Dagestan State Medical University
12/2, M. Khalilova St., Kaspiysk, Republic of Dagestan, 368300,
1 Lenin Square, Makhachkala, Republic of Dagestan, 367000
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Review
For citations:
Mikailova M.T., Zakieva S.I., Magomedova M.M. Sub-tenon’s injection of recombinant prourokinase (Hemase) combined with intravitreal injection of a neoangiogenesis inhibitor (Eylea) in the treatment of massive subretinal hemorrhage in neovascular age-related macular degeneration. A clinical case. Russian Ophthalmological Journal. 2025;18(4):132-138. (In Russ.) https://doi.org/10.21516/2072-0076-2025-18-4-132-138
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