Comparative characteristics of gonioscopy and anterior segment optical coherence tomography in visualizing the iridotrabecular contact
https://doi.org/10.21516/2072-0076-2026-19-1-79-84
Abstract
Purpose: to compare iridotrabecular contact (ITC) imaging findings of gonioscopy and anterior segment optical coherence tomography (AS-OCT) in patients with primary angle closure disease (PACD).
Material and methods. Retrospective analysis of the data from 20 patients with primary angle closure and 23 with early stage primary angle-closure glaucoma aged 49 to 82 years was performed. All participants along with gonioscopy underwent AS-OCT on CASIA2 (Tomey Corporation, Nayoga, Japan) including assessment of the ITC Index and ITC Area.
Results. According to gonioscopy, the average value of the number of sectors of the anterior chamber angle (ACA) of a closed and narrow profile (with a degree of opening from 0 to 2 according to Schaffer) was significantly higher than according to AS-OCT data (3.56 ± 0.65 and 2.04 ± 0.81 respectively, p = 0.02). The degree of opening of the ACA according to Shaffer differed significantly between the superior and inferior (0.06 ± 0.25 and 1.30 ± 1.22, respectively, p = 0.00), superior and nasal (0.06 ± 0.25 and 0.72 ± 1.00, respectively, p = 0.01), temporal and inferior (0.20 ± 0.51 and 1.30 ± 1.22, respectively, p = 0.04) sectors. No significant differences were found between the superior and temporal, nasal and inferior, as well as temporal and nasal sectors (all p > 0.05). According to AS-OCT data, the ITC parameters were: ITC Index = 45.4 ± 21.8% and ITC Area = 5.81 ± 3.90 mm2. Conclusion. In PACD, gonioscopic closure of the ACA (absence of visualization of the trabecular meshwork at least 180°) does not mean the presence of an ITC, as detected by AS-OCT. The superior sector of the ACA is the most vulnerable to angle closure in patients with this pathology.
About the Authors
N. I. KuryshevaRussian Federation
Natalia I. Kurysheva — Dr. of Med. Sci., professor, head of the ophthalmology department, Medical Biological University of Innovations and Continuing Education of the A.I. Burnazyan Federal Biophysical Center; head of the consultative and diagnostic department, Ophthalmological Center of A.I. Burnazyan Federal Medical-Biological Agency, Federal Biophysical Center
8, Zhivopisnaya St., Moscow, 123098,
15, Gamalei St., Moscow, 123098
G. A. Sharova
Russian Federation
Galina A. Sharova — Cand. of Med. Sci., assistant professor at the ophthalmology department, Medical Biological University of Innovations and Continuing Education of the A.I. Burnazyan Federal Biophysical Center; head of the diagnostic ophthalmology department, Ophthalmology Clinic of Dr. Belikova
8, Zhivopisnaya St., Moscow, 123098,
26/2, Budenny Ave, Moscow, 105118
References
1. Foster PJ, Buhrmann R, Quigley HA, Johnson GJ. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002 Feb; 86 (2): 238–42. doi: 10.1136/bjo.86.2.238
2. Clinical guidelines for primary angle-closure glaucoma. Moscow: Ministry of Health of the Russian Federation. 2024 (In Russ.).
3. Kurysheva N.I., Sharova G.A. Primary anterior chamber angle closure: progression from suspect to glaucoma. Part 1. Frequency and rate of transition from suspected primary angle closure to true angle closure and primary angle closure glaucoma. Vestnik oftalmologii. 2022; 138 (4): 101–7 (In Russ.). doi: 10.17116/oftalma2022138041101
4. Thomas R, George R, Parikh R, Muliyil J, Jacob A. Five year risk of progression of primary angle closure suspects to primary angle closure: a population based study. Br J Ophthalmol. 2003; 87 (4): 450–4. https://doi.org/10.1136/bjo.87.4.450
5. Alsbirk PH. Anatomical risk factors in primary angle-closure glaucoma. A ten year follow up survey based on limbal and axial anterior chamber depths in a high risk population. Int Ophthalmol. 1992; 16 (4–5): 265–72. https://doi.org/10.1007/BF00917973
6. Kurysheva N.I., Sharova G.A. Anatomical and topographical characteristics of the eye in the early stages of primary angle closure disease. National Journal glaucoma. 2023; 22 (1): 42–53 (In Russ.). doi: 10.53432/2078-4104-2023-22-1-42-53
7. Chansangpetch S, Rojanapongpun P, Lin SC. Anterior segment imaging for angle closure. Am J Ophthalmol. 2018; 188: xvi-xxix. doi: 10.1016/j.ajo.2018.01.006
8. Kurysheva N.I., Sharova G.A. The role of optical coherence tomography in the diagnosis of angle closed diseases of the anterior chamber. Part 1: Visualization of the anterior segment of the eye. Ophthalmology in Russia. 2021; 18 (2): 208–15 (In Russ.). doi: 10.18008/1816-5095-2021-2-208-215
9. Zhang X, Guo PY, Lin C, et al. Assessment of iris trabecular contact in eyes with gonioscopic angle-closure. Ophthalmology. 2023; 130 (1): 111–9. doi: 10.1016/j.ophtha.2022.08.017
10. Esporcatte BL, Vessani RM, Melo LA Jr, et al. Diagnostic performance of optical coherence tomography and nonspecialist gonioscopy to detect angle closure. J Curr Glaucoma Pract. 2022; 16 (1): 53–8. doi: 10.5005/jp-journals-10078-1354
11. Kurysheva NI, Rodionova OY, Pomerantsev AL, Sharova G.A. Personalized management of physiologic/ophthalmologic particularities for predictive approach and targeted prevention of primary angle closure glaucoma applied to persons at risk. In: Wang W. (ed.). All around suboptimal health. Advances in Predictive, Preventive and Personalised Medicine. 2024; 18: 171–92. doi: 10.1007/978-3-031-46891-9_13
12. Dai Y, Zhang S, Shen M, et al. Modeling of gonioscopic anterior chamber angle grades based on anterior segment optical coherence tomography. Eye Vis (Lond). 2020; 7: 30. doi: 10.1186/s40662-020-00196-1
13. Guo PY, Zhang X, Li F, et al. Diagnostic criteria of anterior segment sweptsource optical coherence tomography to detect gonioscopic angle closure. Br J Ophthalmol. 2024; 108: 1130–6. doi: 10.1136/bjo-2023-323860
14. Young SL, Cheng KKW, O’ Connell N, Sanders R, Agarwal PK. PACS plus criteria: a retrospective cohort review of 612 consecutive patients treated with bilateral YAG peripheral iridotomies. Eye (Lond). 2023; 37 (18): 3834–8. doi: 10.1038/s41433-023-02626-5
15. Yang F, Wu H. Treatment preferences and factors influencing the management of primary angle-closure suspect in China: A national survey study. Ophthalmol Ther. 2024; 13 (1): 11325. doi: 10.1007/s40123-023-00828-4
16. Yuan Y, Wang W, Xiong R, et al. 14-year outcome of angle-closure prevention with laser iridotomy in the Zhongshan Angle Closure Prevention Study: Extended follow-up of a randomized controlled trial. Ophthalmology. 2023; 130 (8): 786–94. doi: 10.1016/j.ophtha.2023.03.024
17. Yu B, Wang K, Zhang X, Xing X. Biometric indicators of anterior segment parameters before and after laser peripheral iridotomy by swept-source optical coherent tomography. BMC Ophthalmol. 2022; 22 (1): 222. doi: 10.1186/s12886-022-02448-1
18. Kurysheva NI, Pomerantsev AL, Rodionova OY, Sharova GA. Comparison of lens extraction versus laser iridotomy on anterior segment, choroid, and intraocular pressure in primary angle closure using machine learning. J Glaucoma. 2023; 32 (6): e43-e55. doi: 10.1097/IJG.0000000000002145
19. Bayraktar S, Yıldırım Erdal BD, Altaş FB, Türkay M, Şen E. The effects of lens extraction surgery on intraocular pressure and anterior segment parameters in primary angle-closure glaucoma. Turk J Ophthalmol. 2024; 54 (1): 32–7. doi: 10.4274/tjo.galenos.2023.82453
20. Chylack LT Jr, Wolfe JK, Singer DM, et al. The lens opacities classification system III. The longitudinal study of Cataract Study Group. Arch Ophthalmol. 1993; 111 (6): 831–6. doi: 10.1001/archopht.1993.01090060119035
21. Xu BY, Pardeshi AA, Burkemper B, et al. Differences in anterior chamber angle assessments between gonioscopy, EyeCam, and anterior segment OCT: The Chinese American Eye Study. Transl Vis Sci Technol. 2019; 8 (2): 5. doi: 10.1167/tvst.8.2
22. Tun TA, Baskaran M, Perera SA, et al. Sectoral variations of iridocorneal angle width and iris volume in Chinese singaporeans: a swept-source optical coherence tomography study. Graefes Arch Clin Exp Ophthalmol. 2014; 252 (7): 1127–32. doi: 10.1007/s00417-014-2636-0
23. He M, Foster PJ, Ge J, et al. Gonioscopy in adult Chinese: the Liwan Eye Study. Invest Ophthalmol Vis Sci. 2006; 47 (11): 4772–9. doi: 10.1167/iovs.06-0309
24. Razeghinejad MR, Myers JS. Contemporary approach to the diagnosis and management of primary angle-closure disease. Surv Ophthalmol. 2018 Nov-Dec; 63 (6): 754–68. doi: 10.1016/j.survophthal.2018.05.001
25. Arkhipova A.N., Turkina K.I. Objective anterior chamber angle evaluation of healthy eyes with optical coherence tomography. Ophthalmology journal. 2017; 10 (3): 18–21 (In Russ.). doi: 10.17816/OV10318-21
26. Sakata LM, Lavanya R, Friedman DS, et al. Comparison of gonioscopy and anterior segment ocular coherence tomography in detecting angle closure in different quadrants of the anterior chamber angle. Ophthalmology. 2008 May; 115 (5): 769–774. doi: 10.1016/j.ophtha.2007.06.030
27. Varma DK, Simpson SM, Rai AS, Ahmed IIK. Undetected angle closure in patients with a diagnosis of open-angle glaucoma. Can J Ophthalmol. 2017 Aug; 52 (4): 373–8. doi: 10.1016/j.jcjo.2016.12.010
28. Varma DK, Kletke SN, Rai AS, Ahmed IIK. Proportion of undetected narrow angles or angle closure in cataract surgery referrals. Can J Ophthalmol. 2017 Aug; 52 (4): 366–72. doi: 10.1016/j.jcjo.2017.01.008
29. Li F, Yang Y, Sun X, et al. Digital gonioscopy based on three-dimensional anterior-segment OCT: An International Multicenter Study. Ophthalmology. 2022; 129 (1): 45–53. doi: 10.1016/j.ophtha.2021.09.018
30. Kurysheva N.I., Pomerantsev A.L., Rodionova O.E., Sharova G.A. Application of artificial intelligence methods in the diagnosis and treatment of primary angle closure disease. Vestnik oftal’mologii. 2024; 140 (5): 130–6 (In Russ.). https://doi.org/10.17116/oftalma2024140051130
31. Yang Y, Wu Y, Guo C, et al. Diagnostic performance of deep learning classifiers in measuring peripheral anterior synechia based on swept source Optical Coherence Tomography Images. Front Med (Lausanne). 2022; 8: 775711. doi: 10.3389/fmed.2021.775711
32. Hao J, Li F, Hao H, et al. Hybrid variation-aware network for angle-closure assessment in AS-OCT. IEEE Trans Med Imaging. 2022; 41 (2): 254–65. doi: 10.1109/TMI.2021.3110602
33. Shan J, Li Z, Ma P, et al. Deep learning classification of angle closure based on anterior segment OCT. Ophthalmol Glaucoma. 2024 Jan-Feb; 7 (1): 8–15. doi: 10.1016/j.ogla.2023.06.011
Review
For citations:
Kurysheva N.I., Sharova G.A. Comparative characteristics of gonioscopy and anterior segment optical coherence tomography in visualizing the iridotrabecular contact. Russian Ophthalmological Journal. 2026;19(1):79-84. (In Russ.) https://doi.org/10.21516/2072-0076-2026-19-1-79-84
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