Assessment of retinal nonperfusion zones dynamics in pregnant women with diabetes mellitus according to optical coherence tomography — angiography
https://doi.org/10.21516/2072-0076-2026-19-1-115-123
Abstract
Purpose of the study was to investigate the possibility of assessing the dynamics of retinal non-perfusion zones in pregnant women with diabetes mellitus (DM) using a standard and the proposed objective method.
Material and methods. Fifty-seven pregnant women (114 eyes) were examined: 28 with DM, including 17 with diabetic retinopathy (DR), and 29 without concomitant somatic pathology. Using optical coherence tomography angiography (OCTA), the total area of non-perfusion zones was assessed using the device software. In addition, an objective assessment of changes in the proportion of retinal non-perfusion zones was performed using the proposed method with a graphic editor.
Results. Throughout pregnancy and 3 months after delivery, patients with DR progression showed a significant increase in the total area of non-perfusion zones. In the third trimester, the proportion of non-perfusion zones in both plexuses was higher in the DM group than in the control. An increase in the proportion of nonperfused zones in both plexuses and a dynamic increase in the total area of retinal nonperfused zones from the first trimester to the third trimester and at 3 months postpartum were found in the subgroup with progressive DR.
Conclusion. OCTA allows for the assessment of changes in nonperfused retina in pregnant women with DM. This method of objectively assessing the dynamics of retinal nonperfusion zones enables quantitative assessment of changes in nonperfused retina areas separately for the superficial and deep retinal plexuses.
About the Authors
N. V. Pomytkina
Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution;
Far Eastern State Medical University
Russian Federation
Russian Federation
Natalia V. Pomytkina — Cand. of Med. Sci., ophthalmologist of laser surgery department, Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution; assistant of general and clinical surgery chair, Far Eastern State Medical University
211, Tikhookeanskaya St., Khabarovsk, 680033,
35, Muravyov-Amurskiy St., Khabarovsk, 680000
E. L. Sorokin
Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution;
Far Eastern State Medical University
Russian Federation
Russian Federation
Evgenii L. Sorokin — Dr. of Med. Sci., professor, deputy head for scientific work, Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution; professor of general and clinical surgery chair, Far Eastern State Medical University
211, Tikhookeanskaya St., Khabarovsk, 680033,
35, Muravyov-Amurskiy St., Khabarovsk, 680000
Ia. E. Pashentsev
Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution
Russian Federation
Russian Federation
Iaroslav E. Pashentsev — junior researcher
211, Tikhookeanskaya St., Khabarovsk, 680033
G. V. Chizhova
Postgraduate Institute for Public Health Workers
Russian Federation
Russian Federation
Galina V. Chizhova — Dr. of Med. Sci., professor, head of the obstetrics and gynecology chair
9, Krasnodarskaya St., Khabarovsk, 680009
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Review
For citations:
Pomytkina N.V., Sorokin E.L., Pashentsev I.E., Chizhova G.V. Assessment of retinal nonperfusion zones dynamics in pregnant women with diabetes mellitus according to optical coherence tomography — angiography. Russian Ophthalmological Journal. 2026;19(1):115-123. (In Russ.) https://doi.org/10.21516/2072-0076-2026-19-1-115-123
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