Аномалия Петерса: клиника, диагностика, дифференциальный диагноз, лечение. Обзор литературы

Представлен анализ литературы, посвященной этиологии, патогенезу, гистологии и клинической картине аномалии Петерса. На основе этих данных и собственного опыта авторы описывают опорные критерии дифференциального диагноза и лечебную тактику, дают прогноз и рекомендации по ведению пациентов с этой тяжелой врожденной аномалией.

1. Salik I, Gupta A, Tara A, Zaidman G, Barst S. Peters anomaly: A 5-year experience. Paediatr Anaesth. 2020 May; 30 (5): 577–83. doi: 10.1111/pan.13843

2. Alkatan HM, Al Dhaheri H, Al Harby M. Terminology of Peters’ anomaly variants: Summary of histopathological findings in 6 corneas and detailed clinicopathological correlation in 2 cases. Saudi J Ophthalmol. 2019 Jul-Sep; 33 (3): 277–82. doi: 10.1016/j.sjopt.2018.02.015

3. Williams AL, Bohnsack BL. Neural crest derivatives in ocular development: discerning the eye of the storm. Birth Defects Res C Embryo Today. 2015 Jun; 105 (2): 87–95. doi: 10.1002/bdrc.21095

4. Traboulsi EI, Maumenee IH. Peters’ anomaly and associated congenital malformations. Arch Ophthalmol. 1992 Dec; 110 (12): 1739–42. doi: 10.1001/archopht.1992.01080240079035

5. Samara A, Eldaya RW. Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review. Radiol Case Rep. 2020 Apr 30; 15 (7): 863–6. doi: 10.1016/j.radcr.2020.04.011

6. Zaidman GW, Flanagan JK, Furey CC. Long-term visual prognosis in children after corneal transplant surgery for Peters anomaly type I. Am J Ophthalmol. 2007 Jul; 144 (1): 104–8. doi: 10.1016/j.ajo.2007.03.058

7. Yang LL, Lambert SR, Lynn MJ, Stulting RD. Surgical management of glaucoma in infants and children with Peters’ anomaly: long-term structural and functional outcome. Ophthalmology. 2004 Jan; 111 (1): 112–7. doi: 10.1016/j.ophtha.2003.02.002

8. Miao S, Lin Q, Liu Y, et al. Clinicopathologic features and treatment characteristics of congenital corneal opacity infants and children aged 3 years or less: A retrospective single institution analysis. Med Princ Pract. 2020; 29 (1): 18–24. doi: 10.1159/000501763

9. Reis LM, Semina EV. Genetics of anterior segment dysgenesis disorders. Curr Opin Ophthalmol. 2011 Sep; 22 (5): 314–24. doi: 10.1097/ICU.0b013e328349412b

10. Chesneau B, Aubert-Mucca M, Fremont F, et al. First evidence of SOX2 mutations in Peters’ anomaly: Lessons from molecular screening of 95 patients. Clin Genet. 2022 May; 101 (5–6): 494–506. doi: 10.1111/cge.14123

11. Honkanen RA, Nishimura DY, Swiderski RE, et al. A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene. Am J Ophthalmol. 2003 Mar; 135 (3): 368–75. doi: 10.1016/s0002-9394(02)02061-5

12. Reis LM, Tyler RC, Volkmann Kloss BA, et al. PITX2 and FOXC1 spectrum of mutations in ocular syndromes. Eur J Hum Genet. 2012 Dec; 20 (12): 1224–33. doi: 10.1038/ejhg.2012.80

13. Плескова А.В., Мазанова Е.В., Катаргина Л.А. Аномалия Петерса: клиника, диагностика и результаты хирургического лечения. Офтальмохирургия. 2019; 2: 44–9.

14. Плескова А.В., Панова А.Ю. Клинические особенности и результаты хирургического лечения врожденных помутнений роговицы у младенцев и детей младше 3 лет. Российская педиатрическая офтальмология. 2023; 18 (4): 185–90 https://ruspoj.com/1993-1859/article/view/569148

15. Плескова А.В., Мазанова Е.В., Сорокин А.А. Актуальные вопросы дифференциальной диагностики и тактика лечения врожденных помутнений роговицы у детей. Офтальмохирургия. 2021; 1: 73–82.

16. Плескова А.В., Гетадарян В.Р., Панова А.Ю. Сравнительный анализ результатов хирургического лечения при аномалии Петерса и склерокорнеа у детей младшего возраста. Российский офтальмологический журнал. 2025; 18 (2): 90–4. https://doi.org/10.21516/2072-0076-2025-18-2-90-94

17. Yang LL, Lambert SR, Lynn MJ, Stulting RD. Long-term results of corneal graft survival in infants and children with peters anomaly. Ophthalmology. 1999 Apr; 106 (4): 833–48. doi: 10.1016/S0161-6420(99)90175-6

18. Nischal KK. A new approach to the classification of neonatal corneal opacities. Curr Opin Ophthalmol. 2012 Sep; 23 (5): 344–54. doi: 10.1097/ICU.0b013e328356893d

19. Myles WM, Flanders ME, Chitayat D, Brownstein S. Peters’ anomaly: a clinicopathologic study. J Pediatr Ophthalmol Strabismus. 1992 Nov-Dec; 29 (6): 374–81. doi: 10.3928/0191-3913-19921101-10

20. Hong J, Yang Y, Cursiefen C, et al. Optimising keratoplasty for Peters’ anomaly in infants using spectral-domain optical coherence tomography. Br J Ophthalmol. 2017 Jun; 101 (6): 820–7. doi: 10.1136/bjophthalmol-2016-308658

21. Scorcia V, Pietropaolo R, Carnevali A, et al. Results of Descemet stripping automated endothelial keratoplasty for the treatment of late corneal decompensation secondary to obstetrical forceps trauma. Cornea. 2016 Mar; 35 (3): 305–7. doi: 10.1097/ICO.0000000000000715

22. Tomatsu S, Pitz S, Hampel U. Ophthalmological findings in mucopolysaccharidoses. J Clin Med. 2019 Sep 14; 8 (9): 1467. doi: 10.3390/jcm8091467

23. Smith JA, Chan CC, Goldin E, Schiffmann R. Noninvasive diagnosis and ophthalmic features of mucolipidosis type IV. Ophthalmology. 2002 Mar; 109 (3): 588–94. doi: 10.1016/s0161-6420(01)00968-x

24. Weiss JS, Møller HU, Aldave AJ, et al. IC3D classification of corneal dystrophies--edition 2. Cornea. 2015 Feb; 34 (2): 117–59. doi: 10.1097/ICO.0000000000000307. Erratum in: Cornea. 2015 Oct; 34 (10): e32. Erratum in: Cornea. 2022 Dec 01; 41 (12): e23. doi: 10.1097/ICO.0000000000003175

25. Pirouzian A. Management of pediatric corneal limbal dermoids. Clin Ophthalmol. 2013; 7: 607–14. doi: 10.2147/OPTH.S38663

26. Elhusseiny AM, Saeed HN. Posterior polymorphous corneal dystrophy in a pediatric population. Cornea. 2022 Jun 1; 41 (6): 734–9. doi: 10.1097/ICO.0000000000002847

27. Patel HY, Ormonde S, Brookes NH, Moffatt LS, McGhee CN. The indications and outcome of paediatric corneal transplantation in New Zealand: 1991–2003. Br J Ophthalmol. 2005 Apr; 89 (4): 404–8. doi: 10.1136/bjo.2004.053116

28. Donoso Rojas R, Jara Urrutia G, López Garin JP. Long-term experience and visual acuity outcomes in patients with Peters Anomaly. J Pediatr Ophthalmol Strabismus. 2021 Sep-Oct; 58 (5): 304–10. doi: 10.3928/01913913-20210412-01

29. Rao KV, Fernandes M, Gangopadhyay N, et al. Outcome of penetrating keratoplasty for Peters anomaly. Cornea. 2008 Aug; 27 (7): 749–53. doi: 10.1097/ICO.0b013e31816fe9a7

30. Hashemi H, Asghari H, Amanzadeh K, et al. Descemet stripping automated endothelial keratoplasty performed by cornea fellows. Cornea. 2012; 31 (9): 974–7. doi: 10.1097/ICO.0b013e318247eaed

31. Soh YQ, Mehta JS. Selective Endothelial removal for Peters Anomaly. Cornea. 2018 Mar; 37 (3): 382–5. doi: 10.1097/ICO.0000000000001472

32. Choe S, Yoon CH, Kim MK, et al. Spontaneous regression of congenital corneal opacity. Graefes Arch Clin Exp Ophthalmol. 2020 Feb; 258 (2): 359–66. doi: 10.1007/s00417-019-04526-5

33. Ramappa M, Chaurasia S, Mohamed A, et al. Selective endothelialectomy in Peter’s Anomaly: A novel surgical technique and its clinical outcomes in children. Cornea. 2022 Dec 1; 41 (12): 1477–86. doi: 10.1097/ICO.0000000000003134

34. Yang LL, Lambert SR, Lynn MJ, Stulting RD. Surgical management of glaucoma in infants and children with Peters’ anomaly: long-term structural and functional outcome. Ophthalmology. 2004 Jan; 111 (1): 112–7. doi: 10.1016/j.ophtha.2003.02.002

35. Najjar DM, Christiansen SP, Bothun ED, Summers CG. Strabismus and amblyopia in bilateral Peter’s anomaly. J AAPOS. 2006 Jun; 10 (3): 193–7. doi: 10.1016/j.jaapos.2006.01.006

36. Elbaz U, Strungaru H, Mireskandari K, Stephens D, Ali A. Long-term visual outcomes and clinical course of patients with Peters Anomaly. Cornea. 2021 Jul 1; 40 (7): 822–30. doi: 10.1097/ICO.0000000000002577

37. Dolezal KA, Besirli CG, Mian SI, et al. Glaucoma and cornea surgery outcomes in Peter’s Anomaly. Am J Ophthalmol. 2019 Dec; 208: 367–75. doi: 10.1016/j.ajo.2019.08.012