Preview

Russian Ophthalmological Journal

Advanced search

Using nonsteroidal anti-inflammatory drugs to prevent retinal macular edema after age-related cataract phacoemulsification

https://doi.org/10.21516/2072-0076-2016-9-2-77-82

Abstract

Retinal macular edema is the most relevant complication of age-related cataract surgery with a poor prognosis for visual function, manifested in the long-term follow-up. Numerous clinical studies indicate that local forms of various nonsteroidal anti-inflammatory drugs (NSAIDS) are effective for the prevention of macular edema (ME) after phacoemulsification. The paper, based on extensive clinical data involving 140 patients, shows that the use of different NSAIDS (indomethacin, nepafenac, ketorolac and bromfenac) after uncomplicated phacoemulsification of age-related cataract in the absence of underlying risk factors contributes to the effective prevention of increased thickness and volume of the retinal macula, prevents the formation of clinically significant ME, and improves visual acuity (which averagely achieves 0.95-0.97). The expanded range of drugs used for the prevention of postoperative macular edema should positively affect the quality of the rehabilitation of patients after cataract phacoemulsification // Russian Ophthalmological Journal, 2016; 2: 77-82 . doi: 10.21516/2072-0076-2016-9-2-77-82 .

About the Authors

I. E. Ioshin
Clinical hospital, Moscow, Russia
Russian Federation


A. I. Tolchinskaya
Clinical hospital, Moscow, Russia
Russian Federation


A. A. Ozderbaeva
Clinical hospital, Moscow, Russia
Russian Federation


References

1. Иошин И.Э. Факоэмульсификация. Москва: Медицина; 2012. Ioshin I.E. Phacoemulsification. Moscow: Meditsina; 2012. (In Russian).

2. Малюгин Б.Э., Шпак А.А., Морозова Т.А. Фармакологическое сопровождение современной хирургии катаракты. Третье издание. Москва: Офтальмология; 2014.

3. Johnson M.W. Etiology and treatment of macular edema. Am. J. Ophthalmol. 2009; 147(1): 11-21.

4. Mentes J., Eracgun T., Afrashi F., Kerci G. Incidence of cystoid macular edema after uncomplicated phacoemulsification. Ophthalmologica. 2003; 217 (6): 408-12.

5. Rey S., Damico D.J. Pseudophakic cystoid macular edema. Semin Ophthalmol. 2002; 17(3-4): 167-80.

6. Астахов С.Ю., Гобеджишвили М.В. Послеоперационный макулярный отек, синдром Ирвина-Гасса. Клиническая офтальмология. 2010; 11(1): 5-8.

7. Галоян Н.С. Влияние хирургической травмы на морфофункциональное состояние центральной зоны сетчатки при различных способах современной хирургии катаракты: Автореферат дис. … канд. мед. наук. Москва; 2004.

8. Гобеджишвили М.В. Состояние центральной зоны сетчатки после факоэмульсификации: Автореферат дис. … канд. мед. наук. Санкт-Петербург; 2011.

9. Solomon L.D. Efficacy of topical flurbiprofen end endomethacin in preventing pseudophakic cystoid macular edema. Flurbiprofen - CME Study Group I. J. Cataract Refract Surg. 1995; 33(1): 73-81.

10. Kim S.J., Flach A.J., Jampol L.M. Nonsteroidal anti-inflammatory drugs in ophthalmology. Survey of Ophthalmology. 2010. 55(2): 108-33.

11. Flach A.J. Nonsteroidal anti-inflammatory drugs. In: Tasman W. (ed). Duanes Foundations of Clinical Ophthalmology. Lippincott; 1994; 2: 1-32.

12. Flach A.J. Discussion: Ketorolac vs. prednisolone vs. combination therapy in the treatment of acute pseudophakic cystoid macular edema. Ophthalmology. 2000; 107(11):2039.

13. Lipter M. НПВС в профилактике кистозного макулярного отека. Eye World. 2003; 6(1): 12.

14. Walters M., Raizman P., Ernest J., et al. In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. J. Cataract Refract Surg. 2007; 33(9): 1539-45.

15. Flach A.J. The incidence, pathogenesis and treatment of cystoid macular edema following cataract surgery. Trans Am. Ophthalmol. Soc. 1998; 96: 557-634.

16. Wittpen J.R., Silverstein S., Heieer L., et al. A randomized, masked comparison of topical ketorolac 0,4% plus steroid vs. steroid alone in low-risk cataract surgery patients. Am. J. Ophthalmol. 2008; 146(4): 554-60.

17. Data on file at ISTA Pharmaceuticals. Inc. Аvailable at: http://bausch.com/portals/109/-/m/BL/United%20States/Files/MSDS/Bromday-bromfenac-ophthalmic-solution-msds.pdf

18. Rho D.S. Treatment of acute pseudophakic cystoid macular edema: diclofenac versus ketorolac. J Cataract Refract Surg. 2003; 29(12): 2378-84.

19. Jett M.F., Ramesha C.S., Brown C.D., et al. Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J. Pharmacol. Exp. Iher. 1999; 288: 1288-97.

20. Weisz J.M., Bressler N.M., Bressler S.B., Schachat A.P. Ketorolac treatment of pseudophakic cystoid macular edema identified more than 24 months after cataract extraction. Ophthalmology. 1999; 106 (9): 1656-9.

21. Tzelikis P., Vieira M., Hida W., et al. Comparison of Ketorolac 0.4% and Nepafenac 0.1% for the Prevention of Cystoid Macular Edema after Phacoemulsification. Prospective Placebo-controlled Randomised Study. Br. J. Ophthalmol. 2015; 99(5): 654-8.


Review

For citations:


Ioshin I.E., Tolchinskaya A.I., Ozderbaeva A.A. Using nonsteroidal anti-inflammatory drugs to prevent retinal macular edema after age-related cataract phacoemulsification. Russian Ophthalmological Journal. 2016;9(2):77-82. (In Russ.) https://doi.org/10.21516/2072-0076-2016-9-2-77-82

Views: 1228


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-0076 (Print)
ISSN 2587-5760 (Online)