The frequency and clinical course of retinopathy of prematurity in modern developmental care conditions as evidenced by the Moscow region perinatal center
https://doi.org/10.21516/2072-0076-2020-13-3-15-20
Abstract
Purpose: to determine the incidence and clinical course of retinopathy of prematurity (ROP) in modern developmental care conditions as based by the data of a level III perinatal center.
Material and methods. A retrospective study of 920 premature infants of the ROP at-risk cohort managed by the Neonatology department of Moscow Regional Perinatal Center over the 2-year period of 2017–2018 was performed. Retinopathy was graded and treated following the respective Federal clinical guidelines.
Results. Of the 920 infants who met the screening criteria, ROP was detected in 193 (28.5 %) infants; 49 infants (7.2 %) required treatment. Of all general somatic factors, the duration of artificial ventilation of lungs showed the strongest correlation with the frequency of development and severity of ROP. In infants with birth weight > 1000 g, the incidence of severe forms of ROP correlated with the presence of necrotizing enterocolitis and intraventricular hemorrhages, while in children with a lower body weight at birth no such correlation was detected. Bronchopulmonary dysplasia was not found to affect the development of ROP. In groups of infants with birth weight of 1000–1499 g and 500–999 g, the frequency of transfusions of washed red blood cells with depleted leukocyte and thrombocyte levels was generally higher in children with ROP, both with spontaneous and induced regression, but showed no difference between the two subgroups.
Conclusion. Severe somatic pathology does not always accompany the progression of ROP to the threshold stage. So, in order to optimize ROP screening, it is necessary to search for new more accurate criteria for ROP development and progression risk.
About the Authors
L. A. Katargina
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Ludmila A. Katargina — Dr. of Med. Sci., professor, deputy director.
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
S. A. Trusova
Moscow Regional Perinatal Center
Russian Federation
Russian Federation
Svetlana A. Trusova — head of the department of pathology of newborns and premature babies.
12, Enthusiasts highway, Balashikha, 143900O. A. Shevernaya
Moscow Regional Perinatal Center
Russian Federation
Russian Federation
Olga A. Shevernaya — ophthalmologist, intensive care unit for newborns, department of pathology of newborns and premature babies.
12, Enthusiasts highway, Balashikha, 143900
N. A. Osipova
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Natalia A. Osipova — Cand. of Med. Sci., ophthalmologist, department of children’s ocular pathology.
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
A. Yu. Panova
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Anna Yu. Panova — PhD student, department of children’s ocular pathology.
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
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Review
For citations:
Katargina L.A., Trusova S.A., Shevernaya O.A., Osipova N.A., Panova A.Yu. The frequency and clinical course of retinopathy of prematurity in modern developmental care conditions as evidenced by the Moscow region perinatal center. Russian Ophthalmological Journal. 2020;13(3):15-20. (In Russ.) https://doi.org/10.21516/2072-0076-2020-13-3-15-20
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