Poppers maculopathy as an effect of drug poisoning. A clinical case
https://doi.org/10.21516/2072-0076-2020-13-3-72-75
Abstract
In recent years, the range of combined narcotic drugs has widened. New chemical modifications have emerged, including so-called designer drugs, whose action on the body and in particular on the state of vision is increasingly difficult to determine. While the problem of drug abuse is growing drastically, timely detection of a possible toxic damage to the eye induced by drugs and reliable diagnosis differentiating such damage from other etiologies becomes a topical practical issue. The paper presents a clinical case of poppers maculopathy (poppers being a slang name of aromatic volatile alkyl nitrite compounds). Ophthalmological manifestations and differential diagnostic criteria of the damage are described. The mechanisms of action and possible treatment methods are discussed.
About the Authors
A. V. Zinov’eva
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Aleksandra V. Zinov’eva — laboratory assistant of the department of eye diseases.
20, Bldg. 1, Delegatskaya St., Moscow, 127473E. E. Ioyleva
A.I. Yevdokimov Moscow State University of Medicine and Dentistry; S. Fyodorov Eye Microsurgery Federal State Institution
Russian Federation
Russian Federation
Elena E. Ioyleva — Dr. of Med. Sci., Professor, scientific secretary.
20, Bldg. 1, Delegatskaya St., Moscow, 127473; 59a, Beskudnikovsky Blvd, Moscow, 127486
N. A. Gavrilova
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Natalia A. Gavrilova — Dr. of Med. Sci., Professor, head of the department of eye diseases.
20, Bldg. 1, Delegatskaya St., Moscow, 127473
References
1. Chakravarthy B., Shah S., Lotfipour S. Adolescent drug abuse — awareness and prevention. Indian J. Med. Res. 2013; 137 (6): 1021–3. PMID: 23852281
2. Pahlitzsch M., Mai C., Joussen A.M., Bergholz R. Poppers maculopathy: complete restitution of macular changes in OCT after drug abstinence. Semin. Ophthalmol. 2016; 31 (5): 479–84. doi: https://doi.org/10.3109/08820538.2014.962175
3. Rewbury R., Hughes E., Purbrick R., Prior S., Baron M. Poppers: legal highs with questionable contents? A case series of poppers maculopathy. Br. J. Ophthalmol. 2017 Nov; 101 (11): 1530–4. doi: 10.1136/bjophthalmol-2016-310023
4. Docherty G., Eslami M., O’Donnell H. Poppers Maculopathy: a case report and literature review. Can. J. Ophthalmol. 2018; 53 (4): 154–5. doi: https://doi.org/10.1016/j.jcjo.2017.10.036
5. Gruener A.M., Jeffries M.A.R., Housseini Z.E., Whitefiald L. Poppers maculopathy. Lancet. 2014; 384 (9954): 1606. doi:https://doi.org/10.1016/S0140-6736(14)60887-4
6. Fawcett R.J., Osborne N.N. Flupirtine attenuates sodium nitroprusside-induced damage to retinal photoreceptors, in situ. Brain Res. Bull. 2007; 73: 278–88. doi: https://doi.org/10.1016/j.brainresbull.2007.04.002
7. Goldstein I.M., Ostwald P., Roth S. Nitric oxide: a review of its role in retinal function and disease. Vision Res. 1996; 36 (18): 2979–94. https://doi.org/10.1016/0042-6989(96)00017-X
8. Ju W.K., Chung I.W., Kim K.Y., et al. Sodium nitroprusside selectively induces apoptotic cell death in the outer retina of the rat. Neuroreport. 2001 Dec 21;
9. Vignal-Clermont C., Audo I., Sahel J.A., Paques M. Poppers-associated retinal toxicity. N. Engl. J. Med. 2010; 363 (16): 1583–5. doi: https://doi.org/10.1056/NEJMc1005118
10. Goureau O., Jeanny J.C., Becquet F., Hartmann M.P., Courtois Y. Protection against light-induced retinal degeneration by an inhibitor of NO synthase. Neuroreport. 1993 Dec 13; 5 (3): 233–6. doi: 10.1097/00001756-199312000-00012
11. Davies A.J., Kelly S.P., Naylor S.G., et al. Adverse ophthalmic reaction in poppers users: case series of 'poppers maculopathy'. Eye. 2012; 26 (11): 1479–86. doi: https://doi.org/10.1038/eye.2012.191
12. Hui M., Galvin J., Chilov M., Gabrielle P.H., Fung A.T. Popper maculopathy: long-term follow-up and case series. Retin. Cases Brief Rep. 2017; 0: 1–5. doi: https://doi.org/10.1097/ICB.0000000000000650
13. Clemens C.R., Alten F., Loos D., et al. Poppers maculopathy or retinopathy? Eye. 2015; 49: 148–9. https://doi.org/10.1038/eye.2014.252
14. Van Bol L.B., Kurt R.A., Keane P.A., Pal B., Sivaprasad S. Clinical phenotypes of poppers maculopathy and their links to visual and anatomic recovery. 2017; 124 (9): 1425–7. doi: https://doi.org/10.1016/j.ophtha.2017.05.021
Review
For citations:
Zinov’eva A.V., Ioyleva E.E., Gavrilova N.A. Poppers maculopathy as an effect of drug poisoning. A clinical case. Russian Ophthalmological Journal. 2020;13(3):72-75. (In Russ.) https://doi.org/10.21516/2072-0076-2020-13-3-72-75
Views:
4762
Email this article 