Multimodal imaging of hereditary retinal dystrophies (a series of clinical cases)
https://doi.org/10.21516/2072-0076-2020-13-4-75-82
Abstract
Multimodal visualization data of inherited retinal degeneration (IRD) on a Mirante platform (Nidek, Japan), used in a number of clinical cases, is compared with the data obtained by electrophysiological diagnostic methods. 4 patients with varying IRD were examined: adult-onset foveomacular vitelliform dystrophy, Stargardt disease, including those with fundus flavimaculatus, and retinitis pigmentosa. Multimodal imaging includes: colour fundus imaging, fundus autofluorescence, retro mode, and optical coherence tomography. Electroretinography was performed using an MBN electroretinograph (Russia), and electrooculography was performed using a RETIscan Science system (Roland Consult, Germany). Using non-invasive retinal imaging methods, specific patterns of inherited dystrophies were shown, which correlated well with the data of electrophysiological research methods. The combination of multimodal imaging on the Mirante platform (Nidek, Japan) in combination with electrophysiological diagnostic methods can be successfully used in complex diagnostics, monitoring of the progression, and evaluation of the results of IRD treatment.
About the Authors
S. V. Milash
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Sergei V. Milash — researcher, department of refraction pathology, binocular vision and ophthalmoergonomics
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
I. V. Zolnikova
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Inna V. Zolnikova — Dr. of Med. Sci., senior research, Kravkov laboratory of clinical electrophysiology of vision
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
V. V. Kadyshev
Research Center for Medical Genetics
Russian Federation
Russian Federation
Vitaly V. Kadyshev — Cand. of Med. Sci., senior research associate of the laboratory of clinical epidemiology
1, Moskvorechie st., Moscow, 115522
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Review
For citations:
Milash S.V., Zolnikova I.V., Kadyshev V.V. Multimodal imaging of hereditary retinal dystrophies (a series of clinical cases). Russian Ophthalmological Journal. 2020;13(4):75-82. (In Russ.) https://doi.org/10.21516/2072-0076-2020-13-4-75-82
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