A clinical and morphological analysis of a retinal and optic nerve astrocytic hamartoma case
https://doi.org/10.21516/2072-0076-2021-14-2-76-80
Abstract
A clinical and morphological description of a case of pilocytic astrocytoma (astrocytic hamartoma) of the retina and optic nerve in an 11-year old girl is presented. The clinical and instrumental characteristics of the tumor are determined by ultrasound and MRI tests. Detailed cytological and pathomorphological description of the tumor, which is rarely observed, is given. The tumor poses a threat to the eye and requires that the eyeball be removed.
About the Authors
S. V. SaakyanRussian Federation
Svetlana V. Saakyan— Dr. of Med. Sci., professor, head of ocular oncology and radiology department
4/19, Sadovaya- Chernogryazskaya St., 105062, Moscow
I. P. Khoroshilova-Maslova
Russian Federation
Inna P. Khoroshilova-Maslova — Dr. of Med. Sci., professor, head of the department of pathologic anatomy and histology
4/19, Sadovaya- Chernogryazskaya St., 105062, Moscow
A. G. Amiryan
Russian Federation
Anush G. Amiryan— Dr. of Med. Sci., principal researcher, ocular oncology and radiology department
4/19, Sadovaya- Chernogryazskaya St., 105062, Moscow
G. P. Zakharova
Russian Federation
Galina P. Zakharova — Cand. of Med. Sci., pathologist, department of pathologic anatomy and histology
4/19, Sadovaya- Chernogryazskaya St., 105062, Moscow
A. Yu. Tsygankov
Russian Federation
Alexander Yu. Tsygankov — Cand. of Med. Sci., junior researcher, ocular oncology and radiology department
4/19, Sadovaya- Chernogryazskaya St., 105062, Moscow
O. G. Panteleeva
Russian Federation
Olga G. Panteleeva — Dr. of Med. Sci., senior researcher, ocular oncology and radiology department
4/19, Sadovaya- Chernogryazskaya St., 105062, Moscow
M. G. Zhiltsova
Russian Federation
Marina G. Zhil’tsova — Cand. of Biol. Sci., senior researcher, ocular
oncology and radiology department
4/19, Sadovaya- Chernogryazskaya St., 105062, Moscow
References
1. Brovkina A.F., Khionidi Ya.N., Fedotova O.F. Astrocytic retinal hamartoma. Rossijskaya pediatricheskaya oftal’mologiya. 2008; 2: 19–20 (in Russian).
2. Myakoshina E.B.Retinal astrocytic hamartoma: two clinical cases, visualization with the help spectral optical coherent tomography. Rossijskaya pediatricheskaya oftal’mologiya. 2013; 1: 23–7 (in Russian)].
3. Shields C.L., Say E.A.T., Fuller T., et al.Retinal astrocytic hamartoma arises in nerve fiber layer and shows “moth-eaten” optically empty spaces on optical coherence tomography. Ophthalmology. 2016; 123 (8): 1809–16. doi: 10.1016/j.ophtha.2016.04.011
4. Herwig M., Laqua H. Klinisches Bild ind Verlaufsbeobachtungen beim astrozytaren Hamartom der Netzhaut und der Papille. Klin. Mbl. Auhenheilk. 1984; 84: 115–20.
5. Olshanskaya A.S., Shnayder N.A., Dmitrienko D.V., et al. Differentiation of retinal astrocytic hamartoma from other retinal neoplasms: a case report. Sibirskij onkologicheskij zhurnal. 2017; 16 (6): 93–9 (in Russian)]. doi: 10.21294/1814-4861-2017-16-6-93-99
6. Astakhov Yu.S., Nechiporenko P.A., Atlasova L.K., et al. Retinal astrocytic hamartoma in tuberous sclerosis. Oftal’mologicheskie vedomosti. 2017; 10 (1): 97–101 (in Russian)]. doi: 10.17816/OV10197-101
7. Wang C., Brucker A.J. Vitreous hemorrhage secondary to juxtapapillary vascular hamartoma of the retina. Retina. 1984; 4: 44–7. doi: 10.1097/00006982-198400410-00007
8. Trincao R., Cunha-Vaz J.G., Pires J.V. Astrocytic hamartoma of the optic disc in localized ocular neurofibromatosis (von Recklinghausen`s disease). Ophthalmologica. 1973; 167: 465–9. doi: 10.1159/000306998
9. Sachdeva R., Rothner D.A., Traboulsi E.I., Hayden B.C., Rychwalski P.J. Astrocytic hamartoma of the optic disc and multiple cafe-au-lait macules in a child with neurofibromatosis type 2. Ophthalmic Genetics. 2010; 31 (4): 209–14. doi: 10.3109/13816810.2010.512356
10. Bec P., Mathis A., Adam P., Maillard P., Alberge Y. Retinitis pigmentosa with astrocytic hamartomas of the optic disc. Ophthalmologica. 1984; 189: 135–8. doi: 10.1159/000309399
11. Loukianou E., Kisma N., Pal B. Evolution of an astrocytic hamartoma of the optic nerve head in a patient with retinitis pigmentosa – photographic documentation over 2 years of follow-up. Case Rep. Ophthalmol. 2011; 2: 45–9. doi: 10.1159/000324037
12. Kiratli H., Turkcouglu P., Bilgic S. Gyrate atrophy associated with astrocytic hamartoma of the optic disc. Retina. 2004; 24 (6): 976–7. doi: 10.1097/00006982-200412000-00025
13. Sebrow D.B., Jung J.J., Dagi Glass L.R., Horowitz J., Chang S. Long-term follow-up of astrocytic hamartoma of the optic disc associated with gyrate atrophy. Ophthalmic Surg. Lasers Imaging Retina. 2015; 46 (3): 387–90. doi: 10.3928/23258160-20150323-17
14. Ulbright T.M., Fulling K.H., Helveston E.M. Astrocytic tumors of the retina. Differentiation of sporadic tumors from phakomatosis-associated tumors. Arch. Pathol. Lab. Med. 1984; 108 (2): 160–3.
15. Saxena S., Meyer C.H. Peripapillary astrocytic hamartomas evolve from the optic nerve. BMJ Case Rep. 2015; pii: bcr2014207275. doi:10.1136/bcr-2014-207275
16. Saakyan S.V., Amiryan A.G., Tsygankov A.Yu., et al.Intraocular schwannoma case report: clinical and pathomorphological analysis. Vestnik oftal'mologii. 2014; 130(2): 54–8 (in Russian)]. doi:10.17116/oftalma2016132664-69
17. Saakyan S.V., Tsygankov A.Yu., Ivanova O.A., et al. Malignant medulloepithelioma mimicking retinoblastoma -clinical and morphological case analysis and cell culture experience. Vestnik oftal'mologii. 2016; 132 (6): 64–9 (in Russian)]. doi:10.17116/oftalma2016132664-69
18. Saakyan S.V., Amiryan A.G.,Tsygankov A.Yu. Uveal melanoma in children and adolescents: the analysis of the original observations of 21 patients. Rossiyskaya pediatricheskaya oftal’mologiya. 2015; 3: 33–6 (in Russian)].
Review
For citations:
Saakyan S.V., Khoroshilova-Maslova I.P., Amiryan A.G., Zakharova G.P., Tsygankov A.Yu., Panteleeva O.G., Zhiltsova M.G. A clinical and morphological analysis of a retinal and optic nerve astrocytic hamartoma case. Russian Ophthalmological Journal. 2021;14(2):76-80. (In Russ.) https://doi.org/10.21516/2072-0076-2021-14-2-76-80