Терапия воспалительных заболеваний передней поверхности и придаточного аппарата глаза у детей в свете современных представлений о множественной лекарственной устойчивости возбудителей

Today, the problem of multiple resistance of pathogens to antibacterial drugs used in the treatment of pyoinflammatory diseases gains importance. At the same time much fewer new antibacterial drugs are registered now, as their investment prospects have become very poor. Hence, we need to maximally enhance the effectiveness of the drugs available on the market. Purpose: to determine the concentration of Ciprofloxacin and Ofloxacin in the tear after regular quantities of eye drops or ointments containing these antibacterial drugs have been instilled into the conjunctival sac, and to compare it with the minimum inhibitory concentration (MIC) for the major pathogens of pyoinflammatory diseases of the anterior segment and the adnexa of children eyes. Material and methods. A randomized study was conducted, which involved 89 patients (100 eyes) aged 1 to 14 years with ocular pyoinflammatory diseases of the anterior segment and the adnexa. The leading pathogens of inflammation and their sensitivity to antibacterial drugs have been identified. A dynamic monitoring of Ciprofloxacin and Ofloxacin concentration in the tear was performed after eye ointment with these antibiotics had been placed into the conjunctival sac. Results. The leading pathogens of inflammatory diseases of the anterior segment and the adnexa in children turned out to be H. influensae (34 %), S. pneumonia (24 %), S. aureus (10 %). With the same sensitivity of the pathogens the eye ointment containing Ciprofloxacin (Oftocipro) shows better results of maintaining the concentration of the drug in the tear exceeding MIC for the leading inflammatory pathogens (H. influensae и S. aureus) of the anterior segment and the adnexa in children for 4 hours after the instillation, as compared to an Ofloxacin-containing ophthalmic ointment (Floxal) and eye drops containing Ciprofloxacin. Conclusion. Oftocipro eye ointment containing Ciprofloxacin is the preferable drug to be prescribed to children in need of the treatment of inflammatory diseases of the anterior segment and the adnexa of the eye // Russian ophthalmological journal. 2017; 10 (2): 87-90. (in Russian). doi: 10.21516/2072-0076-2017-10-2-87-90.

воспаление передней поверхности и придаточного аппарата глаза у детей, конъюнктивит, блефарит, концентрация антибиотика в слезе, глазная мазь, anterior eye surface inflammation and adnexa in children, conjunctivitis, blepharitis, concentration of antibiotics in the tear fluid, ocular ointment

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