Modifying treatment of degenerative retinal diseases. Part 1. Adaptive and non-adaptive retinal plasticity
M. V. Zueva,
N. V. Neroeva,
L. A. Katargina,
A. N. Zhuravleva,
V. I. Kotelin,
I. V. Tsapenko,
D. V. Fadeev https://doi.org/10.21516/2072-0076-2023-16-2-160-165
Abstract
Retinal structural plasticity is manifested in multiple damages of the retina. In many cases, the response to these damages is identical at both the cellular and molecular levels, involves similar sets of cellular signals, and is associated with a change in the structure of the retina and remodeling of the neural connections. The review discusses the common and specific features of adaptive and non-adaptive retinal plasticity, which characterize glaucoma, age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, and retinopathy of prematurity. Given the common features of neurodegeneration and retinal plasticity in brain and retinal diseases, similar therapeutic strategies can be used in many cases to preserve the structure connectivity and retinal function, which stop or slow down the clinical evolution of the disease by either suppressing primary events or enhancing compensatory and regenerative mechanisms in the nervous tissue. Part 2 of the review will present neuroplasticity-based modifying therapy methods for retinal degenerative diseases.
About the Authors
M. V. Zueva
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Marina V. Zueva, Dr. of Biol. Sci., professor, head of the department of clinical physiology of vision named after S.V. Kravkov,
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
N. V. Neroeva
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Natalia V. Neroeva, Cand. of Med. Sci., ophthalmologist, department of pathology of the retina and optic nerve,
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
L. A. Katargina
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Lyudmila A. Katargina, Dr. of Med. Sci., professor, head of the department of eye pathology in children,
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
A. N. Zhuravleva
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Anastasia N. Zhuravleva, Cand. of Med. Sci., researcher, glaucoma department,
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
V. I. Kotelin
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Vladislav I. Kotelin, Cand. of Med. Sci., researcher, department of clinical physiology of vision named after S.V. Kravkov,
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
I. V. Tsapenko
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Irina V. Tsapenko, Cand. of Biol. Sci., chief specialist of the department of clinical physiology of vision named after S.V. Kravkov,
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
D. V. Fadeev
Helmholtz National Medical Research Center of Eye Diseases
Russian Federation
Russian Federation
Denis V. Fadeev, researcher, scientific experimental center,
14/19, Sadovaya-Chernogryazskaya St., Moscow, 105062
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Review
For citations:
Zueva M.V., Neroeva N.V., Katargina L.A., Zhuravleva A.N., Kotelin V.I., Tsapenko I.V., Fadeev D.V. Modifying treatment of degenerative retinal diseases. Part 1. Adaptive and non-adaptive retinal plasticity. Russian Ophthalmological Journal. 2023;16(2):160-165. (In Russ.) https://doi.org/10.21516/2072-0076-2023-16-2-160-165
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